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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphoserine aminotransferase (serC)
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139SubstrateUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Metal bindingi169Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi214Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi270Divalent metal cation; shared with dimeric partnerUniRule annotation1
Binding sitei278SubstrateUniRule annotation1
Binding sitei287SubstrateUniRule annotation1
Binding sitei296SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandCobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciDOLE96561:G1GAC-661-MONOMER
UniPathwayiUPA00244; UER00312

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:Dole_0633
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
Proteomesi
  • UP000008561 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002119131 – 3384-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST338

Proteomic databases

PRIDEiA8ZUN0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi96561.Dole_0633

Structurei

3D structure databases

ProteinModelPortaliA8ZUN0
SMRiA8ZUN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221593
KOiK00097
OMAiAPVHKGV
OrthoDBiPOG091H03XD

Family and domain databases

HAMAPiMF_00536 PdxA, 1 hit
InterProiView protein in InterPro
IPR037510 PdxA
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

A8ZUN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRPLIGIT MGDPVGIGPE IILTALAGTS VYEKCRPLVI GDPGVLGQAM
60 70 80 90 100
AVAGYAPVIH MTDTPETGVY RPGTISMFSP APPLSPVTWG EPTPETGGAM
110 120 130 140 150
EAWITTAVDM AMAGAISAMV TCPINKEALK MAGSAFAGHT EMLAMRTGTN
160 170 180 190 200
RYAMMLAGNR LRVVLVTIHT ALQNVPGLLS VDAIADTILL TVESLKQRFG
210 220 230 240 250
MNAPRVAVAG LNPHAGEGGL FGDEEARLIT PAIEAARRKT EAAITGPWPP
260 270 280 290 300
DTVFVKAAAG DFDAVVCMYH DQGLIPFKLL HFEDGVNTTL GLPIIRTSVD
310 320 330
HGTAYDIAGT GRADCRSLTA AIDMAIDQAA CLGKRPAA
Length:338
Mass (Da):35,285
Last modified:January 15, 2008 - v1
Checksum:i2F821914F8A5FDD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA Translation: ABW66443.1
RefSeqiWP_012174062.1, NC_009943.1

Genome annotation databases

EnsemblBacteriaiABW66443; ABW66443; Dole_0633
KEGGidol:Dole_0633

Similar proteinsi

Entry informationi

Entry nameiPDXA_DESOH
AccessioniPrimary (citable) accession number: A8ZUN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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