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A8ZUJ6

- GCH4_DESOH

UniProt

A8ZUJ6 - GCH4_DESOH

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei146 – 1461May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-2257-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Dole_2224
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260GTP cyclohydrolase FolE2PRO_0000372027Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi96561.Dole_2224.

Structurei

3D structure databases

ProteinModelPortaliA8ZUJ6.
SMRiA8ZUJ6. Positions 12-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8ZUJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDIQKERDF RNMPIDKVGI KNLKYPIRVL DRKNGCQQTV GTINMYVDLP
60 70 80 90 100
HESKGTHMSR FVEMLHILQP EISPKTFSVI LDQMKKDLDA ASAHMEVTFP
110 120 130 140 150
YFIEKAAPVS GTPGFMEYTC KLMGTSRADG RVDLVSEVVV PISSVCPCSK
160 170 180 190 200
EISDGGAHNQ RGEVRLAIRS KKFVWIEDLI QLVEAAASCE LYSVLKRVDE
210 220 230 240 250
KWVTEKGYQN PKFVEDIVRD VAVALKNDTN ITWFNISVEN FESIHNHSAY
260
ATITCGRINP
Length:260
Mass (Da):29,398
Last modified:January 15, 2008 - v1
Checksum:i86A9DB2A2655B11C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW68028.1.
RefSeqiYP_001530105.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW68028; ABW68028; Dole_2224.
GeneIDi5695071.
KEGGidol:Dole_2224.
PATRICi21694577. VBIDesOle35880_2287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000859 Genomic DNA. Translation: ABW68028.1 .
RefSeqi YP_001530105.1. NC_009943.1.

3D structure databases

ProteinModelPortali A8ZUJ6.
SMRi A8ZUJ6. Positions 12-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 96561.Dole_2224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW68028 ; ABW68028 ; Dole_2224 .
GeneIDi 5695071.
KEGGi dol:Dole_2224.
PATRICi 21694577. VBIDesOle35880_2287.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci DOLE96561:GHF3-2257-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3.

Entry informationi

Entry nameiGCH4_DESOH
AccessioniPrimary (citable) accession number: A8ZUJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 15, 2008
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3