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A8ZUJ6

- GCH4_DESOH

UniProt

A8ZUJ6 - GCH4_DESOH

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei146 – 1461May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDOLE96561:GHF3-2257-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Dole_2224
    OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
    Taxonomic identifieri96561 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
    ProteomesiUP000008561: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260GTP cyclohydrolase FolE2PRO_0000372027Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi96561.Dole_2224.

    Structurei

    3D structure databases

    ProteinModelPortaliA8ZUJ6.
    SMRiA8ZUJ6. Positions 12-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8ZUJ6-1 [UniParc]FASTAAdd to Basket

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    MKDIQKERDF RNMPIDKVGI KNLKYPIRVL DRKNGCQQTV GTINMYVDLP    50
    HESKGTHMSR FVEMLHILQP EISPKTFSVI LDQMKKDLDA ASAHMEVTFP 100
    YFIEKAAPVS GTPGFMEYTC KLMGTSRADG RVDLVSEVVV PISSVCPCSK 150
    EISDGGAHNQ RGEVRLAIRS KKFVWIEDLI QLVEAAASCE LYSVLKRVDE 200
    KWVTEKGYQN PKFVEDIVRD VAVALKNDTN ITWFNISVEN FESIHNHSAY 250
    ATITCGRINP 260
    Length:260
    Mass (Da):29,398
    Last modified:January 15, 2008 - v1
    Checksum:i86A9DB2A2655B11C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68028.1.
    RefSeqiYP_001530105.1. NC_009943.1.

    Genome annotation databases

    EnsemblBacteriaiABW68028; ABW68028; Dole_2224.
    GeneIDi5695071.
    KEGGidol:Dole_2224.
    PATRICi21694577. VBIDesOle35880_2287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000859 Genomic DNA. Translation: ABW68028.1 .
    RefSeqi YP_001530105.1. NC_009943.1.

    3D structure databases

    ProteinModelPortali A8ZUJ6.
    SMRi A8ZUJ6. Positions 12-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 96561.Dole_2224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW68028 ; ABW68028 ; Dole_2224 .
    GeneIDi 5695071.
    KEGGi dol:Dole_2224.
    PATRICi 21694577. VBIDesOle35880_2287.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DOLE96561:GHF3-2257-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6200 / Hxd3.

    Entry informationi

    Entry nameiGCH4_DESOH
    AccessioniPrimary (citable) accession number: A8ZUJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3