Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei146 – 1461May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciDOLE96561:GHF3-2257-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Dole_2224
OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)
Taxonomic identifieri96561 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfococcus
ProteomesiUP000008561 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260GTP cyclohydrolase FolE2PRO_0000372027Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi96561.Dole_2224.

Structurei

3D structure databases

ProteinModelPortaliA8ZUJ6.
SMRiA8ZUJ6. Positions 12-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8ZUJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIQKERDF RNMPIDKVGI KNLKYPIRVL DRKNGCQQTV GTINMYVDLP
60 70 80 90 100
HESKGTHMSR FVEMLHILQP EISPKTFSVI LDQMKKDLDA ASAHMEVTFP
110 120 130 140 150
YFIEKAAPVS GTPGFMEYTC KLMGTSRADG RVDLVSEVVV PISSVCPCSK
160 170 180 190 200
EISDGGAHNQ RGEVRLAIRS KKFVWIEDLI QLVEAAASCE LYSVLKRVDE
210 220 230 240 250
KWVTEKGYQN PKFVEDIVRD VAVALKNDTN ITWFNISVEN FESIHNHSAY
260
ATITCGRINP
Length:260
Mass (Da):29,398
Last modified:January 14, 2008 - v1
Checksum:i86A9DB2A2655B11C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68028.1.
RefSeqiYP_001530105.1. NC_009943.1.

Genome annotation databases

EnsemblBacteriaiABW68028; ABW68028; Dole_2224.
KEGGidol:Dole_2224.
PATRICi21694577. VBIDesOle35880_2287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA. Translation: ABW68028.1.
RefSeqiYP_001530105.1. NC_009943.1.

3D structure databases

ProteinModelPortaliA8ZUJ6.
SMRiA8ZUJ6. Positions 12-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi96561.Dole_2224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW68028; ABW68028; Dole_2224.
KEGGidol:Dole_2224.
PATRICi21694577. VBIDesOle35880_2287.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciDOLE96561:GHF3-2257-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6200 / Hxd3.

Entry informationi

Entry nameiGCH4_DESOH
AccessioniPrimary (citable) accession number: A8ZUJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2009
Last sequence update: January 14, 2008
Last modified: March 31, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.