A8ZTA4 (A8ZTA4_DESOH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase HAMAP MF_01023

Gene names

Name:	hisC HAMAP MF_01023
Ordered Locus Names:	Dole_1983

Organism

Desulfococcus oleovorans (strain DSM 6200 / Hxd3) [Complete proteome] [HAMAP]

Taxonomic identifier

96561 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP MF_01023 SAAS SAAS005861 EMBL ABW67787.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	224	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	A8ZTA4 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: B3FDE3EB432CBEB5	FASTA	362	39,365
	10 20 30 40 50 60 MKISPPDYIL SIKPYVPGKP IEELEREYGI SGSIKLASNE NPLGPSPLAL AAIEKALSGL 70 80 90 100 110 120 HRYPDGSGYY LVSKLAQKLG VAPESIVLGN GSDDIIGMLT RALLLPGDEV IMTDPSFAMY 130 140 150 160 170 180 DITTCMVNAR SVYVPLIDRA LPLDTVAGAV TSKTKMVFLT NPNNPTGTVF SGKAFERFLE 190 200 210 220 230 240 AVPSDVVIVV DEAYIEFVQD PECARAFDFL DNSRPLVALR TFSKAYGLAG IRVGYGVMPP 250 260 270 280 290 300 YLAAILNRIR QPFNVNSLAQ VAAIAALDDE AFLKQTLAVV HDGLAWLYAE LEKMGLRCFP 310 320 330 340 350 360 SQANFFLVDV KKDAAAVFEE MLKQGVIIRS MVSYGYPSYI RVTVGLPEEN ARFVAALKAV LK

References

[1]

"Complete sequence of Desulfococcus oleovorans Hxd3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Wawrik B., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6200 / Hxd3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000859 Genomic DNA. Translation: ABW67787.1.
RefSeq	YP_001529864.1. NC_009943.1.
3D structure databases
ProteinModelPortal	A8ZTA4.
ModBase	Search...
Protein-protein interaction databases
STRING	A8ZTA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5694823.
GenomeReviews	Gene locus Dole_1983 in contig CP000859_GR.
KEGG	dol:Dole_1983.
PATRIC	21694077. VBIDesOle35880_2043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646350.
OMA	ENPLGMP.
ProtClustDB	PRK02731.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8ZTA4_DESOH

Accession

Primary (citable) accession number: A8ZTA4

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)