A8ZRY8 (A8ZRY8_DESOH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898

Gene names

Name:	gyrB HAMAP MF_01898
Ordered Locus Names:	Dole_0095

Organism

Desulfococcus oleovorans (strain DSM 6200 / Hxd3) [Complete proteome] [HAMAP]

Taxonomic identifier

96561 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus

Protein attributes

Sequence length	814 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU003363 SAAS SAAS002288 HAMAP MF_01898
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898
Subcellular location	Cytoplasm By similarity HAMAP MF_01898.
Sequence similarities	Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380 Contains 1 Toprim domain. SAAS SAAS002288 HAMAP MF_01898

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01898
Ligand	ATP-binding SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8ZRY8 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 867F8BF13EE99D5D	FASTA	814	91,786
	10 20 30 40 50 60 MKKEEIKEAY NESSINVLEG LEPVRKRPSM YIGNVDKEGL HHLVYEVVDN SIDEAMAGYC 70 80 90 100 110 120 DFIHVIIHKD NTVSVVDNGR GIPVGMHEKE HVPAVEVVLT KLHAGGKFDN NNYKVSGGLH 130 140 150 160 170 180 GVGISVVNAL SSFLEVNVYR DGKIYKQTFS EGQKTSELEI IGDTTQRGTK IIFKPDTTIM 190 200 210 220 230 240 NTDNFSFDIL TRRLRELAFL NNGVRIKIED HRSDESAEFF YEGGLATFVD YLNRAHAVLH 250 260 270 280 290 300 KPIYISGEKN DVQIEAAIQY NDSYSETMYS FANNINTVEG GFHLIGFKGA LTRSINQYAA 310 320 330 340 350 360 SQGGGSSKKN GDKITGDDVR EGLTAVISVR IKNPQFEGQT KTKLGNSEVK GYVDSLVYEK 370 380 390 400 410 420 LNIFLEENPS VGKIIIKKAT EAARARNAAK KARDIARSQG SLLDSSLPGK LAECQSSIPA 430 440 450 460 470 480 ERELFLVEGD SAGGSAKQGR DRRFQAILPL KGKILNIEKA RFDKILKSEE IKNIITVLGT 490 500 510 520 530 540 GVGSEEYNIE KIKYHKVIIM TDADVDGAHI RTLLLTFFFR QMQDLIKQGH LYIAQPPLFK 550 560 570 580 590 600 VGRGKKEVYI DSELLLKDYF IQNACEKKYV KTGEKKLQDH ELYLFLCNLS EFISEMAGLK 610 620 630 640 650 660 RRGYNSKLIE TLIRQNIREK SLLQDRDRVA ALQQTLSENG FVVDDVLYNE EKEMYEFLVT 670 680 690 700 710 720 IPLHEDEEEA VTGSAKKDIK PVRIGRNLIY SNRYQNIVML SEKIAPYNVP PFTVYNSDTD 730 740 750 760 770 780 QEEARFDTVK QLYQYMEALG KKGVVFQRYK GLGEMNADQL WQTTMEPETR KLLKVTIDDA 790 800 810 AEADAVFTLL MGDVVEPRKK FIQENALEVE TLDI

References

[1]

"Complete sequence of Desulfococcus oleovorans Hxd3." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Wawrik B., Richardson P. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6200 / Hxd3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000859 Genomic DNA. Translation: ABW65905.1.
RefSeq	YP_001527982.1. NC_009943.1.
3D structure databases
ProteinModelPortal	A8ZRY8.
ModBase	Search...
Protein-protein interaction databases
STRING	A8ZRY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5692910.
GenomeReviews	Gene locus Dole_0095 in contig CP000859_GR.
KEGG	dol:Dole_0095.
PATRIC	21690137. VBIDesOle35880_0099.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG304889.
OMA	DCSSRDP.
ProtClustDB	PRK14939.
Family and domain databases
HAMAP	MF_01898. GyrB. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR011557. GyrB. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013759. Topo_IIA_B/N_ab. IPR002288. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR013760. Topo_IIA_cen. IPR018522. TopoIIA_CS. IPR006171. Toprim_domain. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KO	K02470.
Pfam	PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
PRINTS	PR00418. TPI2FAMILY.
SMART	SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01059. GyrB. 1 hit.
PROSITE	PS00177. TOPOISOMERASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8ZRY8_DESOH

Accession

Primary (citable) accession number: A8ZRY8

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)