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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi282Magnesium or manganese 1UniRule annotation1
Metal bindingi294Magnesium or manganese 1UniRule annotation1
Metal bindingi294Magnesium or manganese 2UniRule annotation1
Metal bindingi296Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 209ATPUniRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Ccon26_10470
ORF Names:CCC13826_0112
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000001121 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000747641 – 346D-alanine--D-alanine ligaseAdd BLAST346

Structurei

3D structure databases

ProteinModelPortaliA8Z6L3
SMRiA8Z6L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 326ATP-graspUniRule annotationAdd BLAST194

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A8Z6L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLGVIFGAK SFEHEISIVS AIVLKNVLKQ GLKFIFCDAN RDFYLIEQKD
60 70 80 90 100
MRANFFSSGK YKNSKKLSLA KGGFYTHSLF GANKVECDVI INLIHGMDGE
110 120 130 140 150
DGKIAALFEF YGVKYIGPRL EASALSYNKE LTKFLAQKAG VKALDYEMLT
160 170 180 190 200
RQSEPKFHYP IILKPARLGS SIGVSVVHDD SELAYAKDVA FEFDKDVLVE
210 220 230 240 250
PFIKGVKEYN LAGCRIDGKI KFSIVEEPKK KEFLDYEQKY LSFSNENKVK
260 270 280 290 300
EAEISEELKQ KLKFNFSKIY DCGFDGAIIR CDFFVIDDEV YLNEINPNPG
310 320 330 340
SLANYLFEDF ESTLNALANS LPKEREIKID YKFINSITSV KGSGKL
Length:346
Mass (Da):39,166
Last modified:January 15, 2008 - v1
Checksum:iCC6EBA310CC8D37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA Translation: ABW74793.1
RefSeqiWP_048809820.1, NC_009802.2

Genome annotation databases

EnsemblBacteriaiABW74793; ABW74793; CCC13826_0112
KEGGicco:CCC13826_0112

Similar proteinsi

Entry informationi

Entry nameiDDL_CAMC1
AccessioniPrimary (citable) accession number: A8Z6L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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