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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 678ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ccon26_04790
ORF Names:CCC13826_1498
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Formate--tetrahydrofolate ligasePRO_1000073554Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8Z6G1.
SMRiA8Z6G1. Positions 4-547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

OMAiCGEIMTM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z6G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK
60 70 80 90 100
LILVTATNPT PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK
110 120 130 140 150
GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLK
160 170 180 190 200
IEKILWKRCM DMNDRALRFI TVGQGGRTDG VPREDGFNIT AASEIMAVLC
210 220 230 240 250
LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL LKDAIKPNLF
260 270 280 290 300
QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA
310 320 330 340 350
EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI
360 370 380 390 400
ENLGGHIENL KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC
410 420 430 440 450
ENFLKGGKGA LELAELVLKA CDKPSKINFT YEMSDDTKTK IEKVAKEIYG
460 470 480 490 500
AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA KTQYSFSDDA KLLGRAKGFT
510 520 530 540
FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID AEGKIDGLS
Length:549
Mass (Da):59,528
Last modified:January 15, 2008 - v1
Checksum:i2BC4D90EA935325E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1.

Genome annotation databases

EnsemblBacteriaiABW74745; ABW74745; CCC13826_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1.

3D structure databases

ProteinModelPortaliA8Z6G1.
SMRiA8Z6G1. Positions 4-547.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW74745; ABW74745; CCC13826_1498.

Phylogenomic databases

OMAiCGEIMTM.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiFTHS_CAMC1
AccessioniPrimary (citable) accession number: A8Z6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.