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A8Z6G1

- FTHS_CAMC1

UniProt

A8Z6G1 - FTHS_CAMC1

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 678ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ccon26_04790
ORF Names:CCC13826_1498
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Formate--tetrahydrofolate ligasePRO_1000073554Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8Z6G1.
SMRiA8Z6G1. Positions 4-547.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

OMAiIANSVSM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z6G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK
60 70 80 90 100
LILVTATNPT PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK
110 120 130 140 150
GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLK
160 170 180 190 200
IEKILWKRCM DMNDRALRFI TVGQGGRTDG VPREDGFNIT AASEIMAVLC
210 220 230 240 250
LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL LKDAIKPNLF
260 270 280 290 300
QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA
310 320 330 340 350
EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI
360 370 380 390 400
ENLGGHIENL KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC
410 420 430 440 450
ENFLKGGKGA LELAELVLKA CDKPSKINFT YEMSDDTKTK IEKVAKEIYG
460 470 480 490 500
AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA KTQYSFSDDA KLLGRAKGFT
510 520 530 540
FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID AEGKIDGLS
Length:549
Mass (Da):59,528
Last modified:January 15, 2008 - v1
Checksum:i2BC4D90EA935325E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1.

Genome annotation databases

EnsemblBacteriaiABW74745; ABW74745; CCC13826_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1 .

3D structure databases

ProteinModelPortali A8Z6G1.
SMRi A8Z6G1. Positions 4-547.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW74745 ; ABW74745 ; CCC13826_1498 .

Phylogenomic databases

OMAi IANSVSM.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiFTHS_CAMC1
AccessioniPrimary (citable) accession number: A8Z6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3