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A8Z6G1 (FTHS_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Ccon26_04790
ORF Names:CCC13826_1498
OrganismCampylobacter concisus (strain 13826) [Complete proteome] [HAMAP]
Taxonomic identifier360104 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000073554

Regions

Nucleotide binding60 – 678ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A8Z6G1 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 2BC4D90EA935325E

FASTA54959,528
        10         20         30         40         50         60 
MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK LILVTATNPT 

        70         80         90        100        110        120 
PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK GGAAGGGYSQ LAPMEDLNLH 

       130        140        150        160        170        180 
FTGDFHAITS ANNLISAMID NSLYQENPLK IEKILWKRCM DMNDRALRFI TVGQGGRTDG 

       190        200        210        220        230        240 
VPREDGFNIT AASEIMAVLC LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL 

       250        260        270        280        290        300 
LKDAIKPNLF QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA 

       310        320        330        340        350        360 
EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI ENLGGHIENL 

       370        380        390        400        410        420 
KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC ENFLKGGKGA LELAELVLKA 

       430        440        450        460        470        480 
CDKPSKINFT YEMSDDTKTK IEKVAKEIYG AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA 

       490        500        510        520        530        540 
KTQYSFSDDA KLLGRAKGFT FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID 


AEGKIDGLS 

« Hide

References

[1]"Genome sequence of Campylobacter concisus 13826 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13826.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000792 Genomic DNA. Translation: ABW74745.1.

3D structure databases

ProteinModelPortalA8Z6G1.
SMRA8Z6G1. Positions 4-547.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW74745; ABW74745; CCC13826_1498.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIANSVSM.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CAMC1
AccessionPrimary (citable) accession number: A8Z6G1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways