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A8Z6G1

- FTHS_CAMC1

UniProt

A8Z6G1 - FTHS_CAMC1

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 678ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ccon26_04790
    ORF Names:CCC13826_1498
    OrganismiCampylobacter concisus (strain 13826)
    Taxonomic identifieri360104 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000001121: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Formate--tetrahydrofolate ligasePRO_1000073554Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA8Z6G1.
    SMRiA8Z6G1. Positions 4-547.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    OMAiIANSVSM.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8Z6G1-1 [UniParc]FASTAAdd to Basket

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    MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK    50
    LILVTATNPT PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK 100
    GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLK 150
    IEKILWKRCM DMNDRALRFI TVGQGGRTDG VPREDGFNIT AASEIMAVLC 200
    LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL LKDAIKPNLF 250
    QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA 300
    EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI 350
    ENLGGHIENL KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC 400
    ENFLKGGKGA LELAELVLKA CDKPSKINFT YEMSDDTKTK IEKVAKEIYG 450
    AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA KTQYSFSDDA KLLGRAKGFT 500
    FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID AEGKIDGLS 549
    Length:549
    Mass (Da):59,528
    Last modified:January 15, 2008 - v1
    Checksum:i2BC4D90EA935325E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: ABW74745.1.

    Genome annotation databases

    EnsemblBacteriaiABW74745; ABW74745; CCC13826_1498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000792 Genomic DNA. Translation: ABW74745.1 .

    3D structure databases

    ProteinModelPortali A8Z6G1.
    SMRi A8Z6G1. Positions 4-547.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW74745 ; ABW74745 ; CCC13826_1498 .

    Phylogenomic databases

    OMAi IANSVSM.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13826.

    Entry informationi

    Entry nameiFTHS_CAMC1
    AccessioniPrimary (citable) accession number: A8Z6G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3