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A8Z6G1

- FTHS_CAMC1

UniProt

A8Z6G1 - FTHS_CAMC1

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Ccon26_04790, CCC13826_1498
Organism
Campylobacter concisus (strain 13826)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 678ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Ccon26_04790
ORF Names:CCC13826_1498
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000001121: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000073554Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8Z6G1.
SMRiA8Z6G1. Positions 4-547.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiIANSVSM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z6G1-1 [UniParc]FASTAAdd to Basket

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MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK    50
LILVTATNPT PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK 100
GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLK 150
IEKILWKRCM DMNDRALRFI TVGQGGRTDG VPREDGFNIT AASEIMAVLC 200
LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL LKDAIKPNLF 250
QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA 300
EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI 350
ENLGGHIENL KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC 400
ENFLKGGKGA LELAELVLKA CDKPSKINFT YEMSDDTKTK IEKVAKEIYG 450
AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA KTQYSFSDDA KLLGRAKGFT 500
FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID AEGKIDGLS 549
Length:549
Mass (Da):59,528
Last modified:January 15, 2008 - v1
Checksum:i2BC4D90EA935325E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1.

Genome annotation databases

EnsemblBacteriaiABW74745; ABW74745; CCC13826_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000792 Genomic DNA. Translation: ABW74745.1 .

3D structure databases

ProteinModelPortali A8Z6G1.
SMRi A8Z6G1. Positions 4-547.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW74745 ; ABW74745 ; CCC13826_1498 .

Phylogenomic databases

OMAi IANSVSM.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter concisus 13826 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13826.

Entry informationi

Entry nameiFTHS_CAMC1
AccessioniPrimary (citable) accession number: A8Z6G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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