A8Z6G1 (FTHS_CAMC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Ccon26_04790
ORF Names:	CCC13826_1498

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_1000073554
Regions
	Nucleotide binding	60 – 67	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8Z6G1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 2BC4D90EA935325E	FASTA	549	59,528
	10 20 30 40 50 60 MLSDIEITHQ TKLEHISKVA AKLGLNEDEL ELYGKFKAKI SPRLEPSNSK LILVTATNPT 70 80 90 100 110 120 PYGEGKTTMS IGLADALNSL NKKVCLALRE PSLGPVFGIK GGAAGGGYSQ LAPMEDLNLH 130 140 150 160 170 180 FTGDFHAITS ANNLISAMID NSLYQENPLK IEKILWKRCM DMNDRALRFI TVGQGGRTDG 190 200 210 220 230 240 VPREDGFNIT AASEIMAVLC LATSLSDLKE RVANIMVAYD SDKKPIYVRD LGCEDAVCIL 250 260 270 280 290 300 LKDAIKPNLF QTLEHTPTLV HGGPFANIAH GCNSVIATKT ALNLADYVIT EAGFGSELGA 310 320 330 340 350 360 EKFLDIKCRV AEIKPSAVVL VSTIRSLKYN GEANKDEITK PDMNALKKGI ENLGGHIENL 370 380 390 400 410 420 KGKFGQNVVV ALNKFGFDTD EEINFVKEYC QKLGIEVAVC ENFLKGGKGA LELAELVLKA 430 440 450 460 470 480 CDKPSKINFT YEMSDDTKTK IEKVAKEIYG AGEVVFEEAA LKKLEMIKEL NLSHLPVCIA 490 500 510 520 530 540 KTQYSFSDDA KLLGRAKGFT FSVKDLDIRT GAGFIVAVCG KIMLMPGLPK VPAAVNMKID AEGKIDGLS

References

[1]

"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13826.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000792 Genomic DNA. Translation: ABW74745.1.
3D structure databases
ProteinModelPortal	A8Z6G1.
SMR	A8Z6G1. Positions 4-547.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus Ccon26_04790 in contig CP000792_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	EIMAVLC.
Enzyme and pathway databases
BioCyc	CCON360104:CCC13826_1498-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_CAMC1

Accession

Primary (citable) accession number: A8Z6G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	January 15, 2008
Last modified:	October 19, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program