Reviewed, UniProtKB/Swiss-Prot A8Z6F6 (RNC_CAMC1)

Names and origin

Protein names

Recommended name:
    Ribonuclease 3
    EC=3.1.26.3
Alternative name(s):
    Ribonuclease III
      Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	Ccon26_03320
ORF Names:	CCC13826_0792

Organism

Campylobacter concisus (strain 13826) [Complete proteome] [HAMAP]

Taxonomic identifier

360104 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: HAMAP rRNA catabolic process Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Ribonuclease 3 HAMAP MF_00104		PRO_1000075732
Regions
	Domain	4 – 127	124	RNase III
	Domain	154 – 223	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	A8Z6F6-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: BFB371FF0DD3A28D	FASTA	223	25,123
	10 20 30 40 50 60 MKNLEEFERN LGYKFKKSEL LEEALTHKST KQALNNERLE FLGDAVMDLL VAEYLFKKFS 70 80 90 100 110 120 KIAEGDMSKL RAALVNEKSF ANMARRLKMG EFLRLSQAEE NNGGREKDSI LSDAFEAVMG 130 140 150 160 170 180 AIYLEAGLLK VREISISLLE LCYPQIDFAH LEKDYKTALQ EVTQATLGVI PTYELIGSFG 190 200 210 220 PDHKKEFEIA LLLNGKEISR AVGSSKKQAQ QLAAKIALEK IKK

References

[1]	"Genome sequence of Campylobacter concisus 13826 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., On S., Nelson K.E. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000792 Genomic DNA. Translation: ABW74738.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus Ccon26_03320 in contig CP000792_GR.
KEGG	cco:CCC13826_0792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ALTHKSF.
Family and domain databases
HAMAP	MF_00104. [Tree]
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_CAMC1

Accession

Primary (citable) accession number: A8Z6F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)