A8Z666 (EFG_SULMW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	SMGWSS_220

Organism

Sulcia muelleri (strain GWSS) [Complete proteome] [HAMAP]

Taxonomic identifier

444179 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Candidatus Sulcia

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	Elongation factor G HAMAP MF_00054_B		PRO_1000074975
Regions
	Nucleotide binding	15 – 22	8	GTP By similarity
	Nucleotide binding	83 – 87	5	GTP By similarity
	Nucleotide binding	137 – 140	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8Z666 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: D731966681D32083	FASTA	693	78,215
	10 20 30 40 50 60 MKNNLKYTRN IGIAAHIDAG KTTTTERILF YTGINHKIGE VHDGTATMDW MEQEQERGIT 70 80 90 100 110 120 ITSAATKCEW LYNNNIYKIN IIDTPGHVDF TVEVERSLRV LDGMVALFSA VDGVEPQSET 130 140 150 160 170 180 VWRQADKYKV PRIGFVNKMD RQGADFFNVC EQIKSNLGAN CLILQIPIGI EDNFQGVVDI 190 200 210 220 230 240 ISKKAIIWDE KNYGTSYNIR TIPEELLELT NKYRNILIET ISEYDYDIMG KYFSNPNEIS 250 260 270 280 290 300 ENDIISSIKK STINLDIVPI ICGSSFKNKG VQVMLDAICR YLPSPIDIKE TKGINPKTEK 310 320 330 340 350 360 EEIRKHNSKE PFSALAFKIA TDSFVGRLAF FRVYSGQLKS GTYILNSRSG NKERISRIYQ 370 380 390 400 410 420 MHANKQNPVN IIEAGDIGAA VGFKDIKTGD TLCDENYPII YENISFPDPV IGLAIEPKYK 430 440 450 460 470 480 SDIDKMSLAL SKLSEEDPTF IVRNDKYTGQ TIISGMGELH LEIILDRMER EFKVKVNKGN 490 500 510 520 530 540 PQVEYKEALT NSIEHREIYK KQTGGRGKYA DILFKLEPGK KGAQGLEFIN KVKGGNIPKE 550 560 570 580 590 600 YIPSIEKAFK EAMKNGPLYG YEINNARIIL IDGSYHSVDS DQLSFELASK IGFKNAAKKT 610 620 630 640 650 660 NPIILEPIMK LEVLTPPENM GNIVGDINRR RGIIQGMEEN RSNSKIIKAL VPLSELFGYV 670 680 690 TILRTLSSGR ATSTMEFYKY KPKPAPYNIL NKK

References

[1]	"Parallel genomic evolution and metabolic interdependence in an ancient symbiosis." McCutcheon J.P., Moran N.A. Proc. Natl. Acad. Sci. U.S.A. 104:19392-19397(2007) [PubMed: 18048332] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GWSS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000770 Genomic DNA. Translation: ABS30617.1.
RefSeq	YP_001598013.1. NC_010118.1.
3D structure databases
ProteinModelPortal	A8Z666.
ModBase	Search...
Protein-protein interaction databases
STRING	A8Z666.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5797181.
GenomeReviews	Gene locus SMGWSS_220 in contig CP000770_GR.
KEGG	smg:SMGWSS_220.
PATRIC	32019137. VBICanSul12747_0183.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG737692.
OMA	CNEWREK.
ProtClustDB	PRK12739.
Enzyme and pathway databases
BioCyc	CSUL444179:SMGWSS_220-MONOMER.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_SULMW

Accession

Primary (citable) accession number: A8Z666

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program