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A8Z660

- PNP_SULMW

UniProt

A8Z660 - PNP_SULMW

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, SMGWSS_214
Organism
Sulcia muelleri (strain GWSS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi509 – 5091Magnesium By similarity
Metal bindingi515 – 5151Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCSUL444179:GHLI-212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:SMGWSS_214
OrganismiSulcia muelleri (strain GWSS)
Taxonomic identifieri444179 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCandidatus Sulcia
ProteomesiUP000000781: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444179.SMGWSS_214.

Structurei

3D structure databases

ProteinModelPortaliA8Z660.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini576 – 63863KH
Add
BLAST
Domaini648 – 71568S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z660-1 [UniParc]FASTAAdd to Basket

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MIPELIKENL FLEDGRALSI ETGELARKAN GSAVVRMGNT SLLATVVISK    50
ESKEDFKFIP LTIDYREKYS AGGKIPGGYI KREGRPYDEE ILTMRLVDRL 100
LRPLFKDNYY NEIQIMISLL SYDINVLPDG LAGLVASTAV SISEISFQGP 150
VSTVRIIRIN DAFIINPGIE EIKKSDFYLD LDLDLDLIVG GTNNYIILVE 200
GEMREISEIE MMEAIVKAHK YIQLQIEAQI SLITKNKKFI KKKLYKIELY 250
NYYYKYINFN LNVFYIKEKI KFISYEEIDY IYKSCLFKQK RSNKIYNILK 300
KIKFHFYNES IVINNLEIDI IFDEIKKEII KNILFKENIR LDGRSLDDIR 350
NICSQVDCLP GVHGSAIFTR GETQALSTVT LGSSLDVNKI DNAIMRAKQR 400
FYLHYNFPPF STGEIKLLKG VSRREIGHGN LAQRALKNII PTTYTIRVVS 450
DVLESNGSSS MATVCASTLA LMDSGIIVKR PVSGISMGLI MNYLTGEAII 500
LSDLLGDEDY IGDMDFKITG TEYGMTACQM DIKISGITYD VLSYTIFKAK 550
KGLLFIIKKM LTTLSCPRKS LNITATKIYT FYIPKKLIGA VIGSGGKRIQ 600
EIQVSTETNI KIKEKNYLGV IEILGKNETK LKIAILKIKN ITFVPKVGTI 650
YKAKVKNIKK FGVFVKISKY LEGLLHIYEI SWLTKVESFI RKGDIISVKY 700
LGKNNKFRKI KLSHKMIFSR YYLNKNLK 728
Length:728
Mass (Da):82,950
Last modified:January 15, 2008 - v1
Checksum:i54CECA1F1A5C4BB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000770 Genomic DNA. Translation: ABS30611.1.
RefSeqiWP_012220914.1. NC_010118.1.
YP_001598007.1. NC_010118.1.

Genome annotation databases

EnsemblBacteriaiABS30611; ABS30611; SMGWSS_214.
GeneIDi5797221.
KEGGismg:SMGWSS_214.
PATRICi32019125. VBICanSul12747_0177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000770 Genomic DNA. Translation: ABS30611.1 .
RefSeqi WP_012220914.1. NC_010118.1.
YP_001598007.1. NC_010118.1.

3D structure databases

ProteinModelPortali A8Z660.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444179.SMGWSS_214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS30611 ; ABS30611 ; SMGWSS_214 .
GeneIDi 5797221.
KEGGi smg:SMGWSS_214.
PATRICi 32019125. VBICanSul12747_0177.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CSUL444179:GHLI-212-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Parallel genomic evolution and metabolic interdependence in an ancient symbiosis."
    McCutcheon J.P., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 104:19392-19397(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GWSS.

Entry informationi

Entry nameiPNP_SULMW
AccessioniPrimary (citable) accession number: A8Z660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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