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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Sulcia muelleri (strain GWSS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:SMGWSS_103Imported
OrganismiSulcia muelleri (strain GWSS)Imported
Taxonomic identifieri444179 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCandidatus Sulcia
Proteomesi
  • UP000000781 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliA8Z5W7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 326FAD/NAD-binding_domInterPro annotationAdd BLAST323
Domaini345 – 454Pyr_redox_dimInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiCIDEWKN.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8Z5W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYYDVVVIG SGPGGYISAI RCSQLGFNTA IIEKYKYFGG TCLNVGCIPS
60 70 80 90 100
KTLLSSAENY HKAKNMFYKH GIKFDNLLLD FTKMMSIKNN IINKICEGIK
110 120 130 140 150
YLFIKYNIKT YLGTASFKDK NTISILDSKI EIIKFTYAII ATGSKPMELP
160 170 180 190 200
FAKIDGNKII SSTDILSLNY IPKKLSIIGG GVIGIELGSL YNKIGSDVTI
210 220 230 240 250
IEYEKNIISN LDLDLSKELK NILKKNGIKF YLSTKVESID IIKSNVKINA
260 270 280 290 300
KIKKNDEINI ICDCCLLSIG RIPYTNNLGL ENIGIKKDKK GFILVNNNLQ
310 320 330 340 350
TNIENIYAIG DVIGGLMLAH KAEKEGIFVS DKIYGNKNFI NYNLIPSVIY
360 370 380 390 400
TNPEVASVGK SEKELKYFNI KYKIGKFPIK ALGRAISSGE INGFVKILSD
410 420 430 440 450
ELTDEILGIH MIGPRVSDII IEAVLAMEFK ASSEDLSLIS YAHPTFTEAV
460
KEAALIATGN KPIHI
Length:465
Mass (Da):51,489
Last modified:January 15, 2008 - v1
Checksum:iD4A5EE0D9277D31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000770 Genomic DNA. Translation: ABS30518.1.

Genome annotation databases

EnsemblBacteriaiABS30518; ABS30518; SMGWSS_103.
KEGGismg:SMGWSS_103.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8Z5W7_SULMW
AccessioniPrimary (citable) accession number: A8Z5W7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 7, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported