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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Sulcia muelleri (strain GWSS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:SMGWSS_103Imported
OrganismiSulcia muelleri (strain GWSS)Imported
Taxonomic identifieri444179 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCandidatus Sulcia
Proteomesi
  • UP000000781 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliA8Z5W7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 326FAD/NAD-binding_domInterPro annotationAdd BLAST323
Domaini345 – 454Pyr_redox_dimInterPro annotationAdd BLAST110

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiFLMDKNK.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z5W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYYDVVVIG SGPGGYISAI RCSQLGFNTA IIEKYKYFGG TCLNVGCIPS
60 70 80 90 100
KTLLSSAENY HKAKNMFYKH GIKFDNLLLD FTKMMSIKNN IINKICEGIK
110 120 130 140 150
YLFIKYNIKT YLGTASFKDK NTISILDSKI EIIKFTYAII ATGSKPMELP
160 170 180 190 200
FAKIDGNKII SSTDILSLNY IPKKLSIIGG GVIGIELGSL YNKIGSDVTI
210 220 230 240 250
IEYEKNIISN LDLDLSKELK NILKKNGIKF YLSTKVESID IIKSNVKINA
260 270 280 290 300
KIKKNDEINI ICDCCLLSIG RIPYTNNLGL ENIGIKKDKK GFILVNNNLQ
310 320 330 340 350
TNIENIYAIG DVIGGLMLAH KAEKEGIFVS DKIYGNKNFI NYNLIPSVIY
360 370 380 390 400
TNPEVASVGK SEKELKYFNI KYKIGKFPIK ALGRAISSGE INGFVKILSD
410 420 430 440 450
ELTDEILGIH MIGPRVSDII IEAVLAMEFK ASSEDLSLIS YAHPTFTEAV
460
KEAALIATGN KPIHI
Length:465
Mass (Da):51,489
Last modified:January 15, 2008 - v1
Checksum:iD4A5EE0D9277D31C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000770 Genomic DNA. Translation: ABS30518.1.

Genome annotation databases

EnsemblBacteriaiABS30518; ABS30518; SMGWSS_103.
KEGGismg:SMGWSS_103.
PATRICi32018905. VBICanSul12747_0083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000770 Genomic DNA. Translation: ABS30518.1.

3D structure databases

ProteinModelPortaliA8Z5W7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS30518; ABS30518; SMGWSS_103.
KEGGismg:SMGWSS_103.
PATRICi32018905. VBICanSul12747_0083.

Phylogenomic databases

HOGENOMiHOG000276708.
KOiK00382.
OMAiFLMDKNK.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA8Z5W7_SULMW
AccessioniPrimary (citable) accession number: A8Z5W7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.