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A8Z5V9

- DEF_SULMW

UniProt

A8Z5V9 - DEF_SULMW

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Protein

Peptide deformylase

Gene

def

Organism
Sulcia muelleri (strain GWSS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931IronUniRule annotation
Metal bindingi135 – 1351IronUniRule annotation
Active sitei136 – 1361UniRule annotation
Metal bindingi139 – 1391IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCSUL444179:GHLI-93-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:SMGWSS_095
OrganismiSulcia muelleri (strain GWSS)
Taxonomic identifieri444179 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCandidatus Sulcia
ProteomesiUP000000781: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Peptide deformylasePRO_1000076953Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi444179.SMGWSS_095.

Structurei

3D structure databases

ProteinModelPortaliA8Z5V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiEETGEEW.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A8Z5V9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILPIIIYGN SFLRKKCIEI DKSYKDINFL INNMYDTMYQ AKGIGLSAPQ
60 70 80 90 100
IGLSIRLFII EYNNFLKQKF KKVFINPIII KKYGYNLISK EGCLSIPNII
110 120 130 140 150
ENIKRKNNII IEYYDENWKK YKQHFNGLLS IIIQHEYDHI EGKLFIDNIF
160 170 180
ILKNILIKKN FNLNYNLYKL YKLSKLYKFY LIYRSRYRI
Length:189
Mass (Da):22,867
Last modified:January 15, 2008 - v1
Checksum:i6E792111BE4A68BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000770 Genomic DNA. Translation: ABS30510.1.
RefSeqiYP_001597906.1. NC_010118.1.

Genome annotation databases

EnsemblBacteriaiABS30510; ABS30510; SMGWSS_095.
GeneIDi5797255.
KEGGismg:SMGWSS_095.
PATRICi32018889. VBICanSul12747_0075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000770 Genomic DNA. Translation: ABS30510.1 .
RefSeqi YP_001597906.1. NC_010118.1.

3D structure databases

ProteinModelPortali A8Z5V9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 444179.SMGWSS_095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS30510 ; ABS30510 ; SMGWSS_095 .
GeneIDi 5797255.
KEGGi smg:SMGWSS_095.
PATRICi 32018889. VBICanSul12747_0075.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi EETGEEW.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci CSUL444179:GHLI-93-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Parallel genomic evolution and metabolic interdependence in an ancient symbiosis."
    McCutcheon J.P., Moran N.A.
    Proc. Natl. Acad. Sci. U.S.A. 104:19392-19397(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GWSS.

Entry informationi

Entry nameiDEF_SULMW
AccessioniPrimary (citable) accession number: A8Z5V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3