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A8Z5V9 (DEF_SULMW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase

Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:SMGWSS_095
OrganismSulcia muelleri (strain GWSS) [Complete proteome] [HAMAP]
Taxonomic identifier444179 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesCandidatus Sulcia

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Peptide deformylase HAMAP-Rule MF_00163
PRO_1000076953

Sites

Active site1361 By similarity
Metal binding931Iron By similarity
Metal binding1351Iron By similarity
Metal binding1391Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A8Z5V9 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 6E792111BE4A68BF

FASTA18922,867
        10         20         30         40         50         60 
MILPIIIYGN SFLRKKCIEI DKSYKDINFL INNMYDTMYQ AKGIGLSAPQ IGLSIRLFII 

        70         80         90        100        110        120 
EYNNFLKQKF KKVFINPIII KKYGYNLISK EGCLSIPNII ENIKRKNNII IEYYDENWKK 

       130        140        150        160        170        180 
YKQHFNGLLS IIIQHEYDHI EGKLFIDNIF ILKNILIKKN FNLNYNLYKL YKLSKLYKFY 


LIYRSRYRI 

« Hide

References

[1]"Parallel genomic evolution and metabolic interdependence in an ancient symbiosis."
McCutcheon J.P., Moran N.A.
Proc. Natl. Acad. Sci. U.S.A. 104:19392-19397(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GWSS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000770 Genomic DNA. Translation: ABS30510.1.
RefSeqYP_001597906.1. NC_010118.1.

3D structure databases

ProteinModelPortalA8Z5V9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING444179.SMGWSS_095.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS30510; ABS30510; SMGWSS_095.
GeneID5797255.
KEGGsmg:SMGWSS_095.
PATRIC32018889. VBICanSul12747_0075.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHOG000243509.
KOK01462.
OMAFSEGCLS.
OrthoDBEOG664CMF.
ProtClustDBCLSK2541306.

Enzyme and pathway databases

BioCycCSUL444179:GHLI-93-MONOMER.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_SULMW
AccessionPrimary (citable) accession number: A8Z5V9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families