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A8Z5T3 (RPOB_SULMW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:SMGWSS_057
OrganismSulcia muelleri (strain GWSS) [Complete proteome] [HAMAP]
Taxonomic identifier444179 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Candidatus Sulcia

Protein attributes

Sequence length1328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13281328DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000329190

Sequences

Sequence LengthMass (Da)Tools
A8Z5T3 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: C0979F370B3E5222

FASTA1,328153,022
        10         20         30         40         50         60 
MKKIIKIRRF KFPFTKEKTI NFASVRNKIS YPDFLDIQIK SFTNFFCINY TYKNISNKGF 

        70         80         90        100        110        120 
YKVFIEYFPI SDSKNKFIID FISYKIYDPL YSIEECIKRG LTYNVYIRAR FKIYRTRKRK 

       130        140        150        160        170        180 
ITIENKRTKY FETIYQDVYF GTCPYMTPSG SFIFNGSERV IVSQLHRSPG VFFGQYDIPN 

       190        200        210        220        230        240 
LPKISYARII PLKGSWIELS TDINNVMYIY LDIKKRLPIT TLLRALGYTR DIDILNIFNL 

       250        260        270        280        290        300 
AEEVNINKVN YKKFLGRTLA ARIFKTSYQK FEENDILLER NIKLKKYHID IILYYKIKVI 

       310        320        330        340        350        360 
SLYKKNEKNE KNLYYSIIHN TLKKDPTNSQ KEANIYIYKE LKDSFPKNDK KAKLFINKFF 

       370        380        390        400        410        420 
FDETHLGEVG RYKLNKTLKL DFPLKDQILN IEDIISIIEN LIALCNNKKE VDDIDNLANR 

       430        440        450        460        470        480 
RVKTVGEQLY TQYTIGIARV SRIIKERINV KDNETLTPLE LINSKTLTSV INSFFGTDEL 

       490        500        510        520        530        540 
SQFMDQTNPL AEMTHKRRIS SLGPGGLSRE RAGFEIRDVN YSHYGRLCPI ETPEGPNIGL 

       550        560        570        580        590        600 
ISSLCVFAKI NSMGFIETPY FKVKKGKVVI NEAPIYISSD QEYGKLITQA NAILNYKTGV 

       610        620        630        640        650        660 
LKNNIIVRVN ADFPMVNYKK INYIDVSTNQ IASISASLIP FLEHDDANRA LMGSNMMRQS 

       670        680        690        700        710        720 
VPLLNPKAPI VGTGLEKHLA QYVNALIYAE GDGIVESVDA NNIKVKYFNS EKEKLLSFEK 

       730        740        750        760        770        780 
RIKTYKLIKF RKTNQNTCLN IRPIVKKGMY VTKGQVLCEG FATQNGKLAL GRNIKVAFMP 

       790        800        810        820        830        840 
FKGYNFEDAI VISEKVVRED WFTSIHIDEY SLEVRDTKLG MEEFTFDIPN FNEENKKKLD 

       850        860        870        880        890        900 
KYGIIKIGSE VKPGDVLIGR ITPKKEGYPS SEENFLKAIF GKKVGTIKNT SLKADSSLFG 

       910        920        930        940        950        960 
VVIDTKIYSK FSSKEDEQKQ FQIKKLNNKF MKNLKLLRKL LINKLILVLE GSVSEGILNS 

       970        980        990       1000       1010       1020 
SYKEIIPKGK ILNKLNLKKL LKNQEIIYQN WVNNKYKNNL VFKIIKFYYL KINELKIKLK 

      1030       1040       1050       1060       1070       1080 
RKKNRLLIGD EITSGIIKIA KVLIAKKRKL KVGDKMSGRH GNKGIVARIV KEEDMPYLED 

      1090       1100       1110       1120       1130       1140 
GTSVDLVLNP LGVPSRMNLG QIYETILGWA GEKLGINFST PIFDGASIEE ISKYTDIANL 

      1150       1160       1170       1180       1190       1200 
PSFGNTYLFD GETGEKFDQP VTVGVIYMLK LNHMVDDKMH ARSIGPYSLI TQQPLGGKSK 

      1210       1220       1230       1240       1250       1260 
FGGQRLGEME VWALEAFGAA NILREILTVK SDDVKGRTKT YEAIVKRETI PNPGIPESFH 

      1270       1280       1290       1300       1310       1320 
VLLKELKGLG LSLKLEVIKK KEKKNQKIKV RIEIKEKDII KYKKKVKEIK LKKLKELKEQ 


LSKSNKKK

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References

[1]"Parallel genomic evolution and metabolic interdependence in an ancient symbiosis."
McCutcheon J.P., Moran N.A.
Proc. Natl. Acad. Sci. U.S.A. 104:19392-19397(2007) [PubMed: 18048332] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GWSS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000770 Genomic DNA. Translation: ABS30484.1.
RefSeqYP_001597880.1. NC_010118.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8Z5T3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5797356.
GenomeReviewsGene locus SMGWSS_057 in contig CP000770_GR.
KEGGsmg:SMGWSS_057.
PATRIC32018815. VBICanSul12747_0050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285547.
OMAQRDLTYA.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycCSUL444179:SMGWSS_057-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 2 hits.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. RpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_SULMW
AccessionPrimary (citable) accession number: A8Z5T3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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