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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 129cNMPAdd BLAST90
DNA bindingi188 – 207H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:USA300HOU_2631
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003494161 – 234HTH-type transcriptional regulator ArcRAdd BLAST234

Structurei

3D structure databases

ProteinModelPortaliA8Z5D0
SMRiA8Z5D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 228HTH crp-typeAdd BLAST74

Phylogenomic databases

HOGENOMiHOG000022896
KOiK21828
OMAiEYLCKNH

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF13545 HTH_Crp_2, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit

Sequencei

Sequence statusi: Complete.

A8Z5D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY
60 70 80 90 100
FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV
110 120 130 140 150
NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM
160 170 180 190 200
ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE
210 220 230
TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV
Length:234
Mass (Da):27,428
Last modified:January 15, 2008 - v1
Checksum:iA26B08D8A1EA396E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA Translation: ABX30617.1
RefSeqiWP_000138214.1, NC_010079.1

Genome annotation databases

EnsemblBacteriaiABX30617; ABX30617; USA300HOU_2631
KEGGisax:USA300HOU_2631

Similar proteinsi

Entry informationi

Entry nameiARCR_STAAT
AccessioniPrimary (citable) accession number: A8Z5D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health