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Protein

Uridine kinase

Gene

udk

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637
UPA00579; UER00640

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:USA300HOU_1611
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000819751 – 207Uridine kinaseAdd BLAST207

Structurei

3D structure databases

ProteinModelPortaliA8Z4E9
SMRiA8Z4E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262756
KOiK00876
OMAiTTLKPMH

Family and domain databases

CDDicd02023 UMPK, 1 hit
HAMAPiMF_00551 Uridine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR006083 PRK/URK
IPR000764 Uridine_kinase-like
IPR026008 Uridine_kinase_
PfamiView protein in Pfam
PF00485 PRK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00235 udk, 1 hit

Sequencei

Sequence statusi: Complete.

A8Z4E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATTIIGIA GGSGSGKTTV TNEIMKNLEG HSVALLAQDY YYKDQKHLTF
60 70 80 90 100
DERLETNYDH PFAFDNDLLI ENLKDLKNGK AVEVPTYDYA SHTRSDITID
110 120 130 140 150
FKPKDVIIVE GIFALENKVL RDMMDVKIYV DTDADLRILR RLTRDTKERG
160 170 180 190 200
RSMDSVINQY LSVVRPMHDQ FIEPTKKYAD IIIPEGGSNK VAIDIMTTKI

QSLVSKQ
Length:207
Mass (Da):23,505
Last modified:January 15, 2008 - v1
Checksum:iFD3A6D46E531DB8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA Translation: ABX29618.1
RefSeqiWP_000648617.1, NC_010079.1

Genome annotation databases

EnsemblBacteriaiABX29618; ABX29618; USA300HOU_1611
KEGGisax:USA300HOU_1611

Similar proteinsi

Entry informationi

Entry nameiURK_STAAT
AccessioniPrimary (citable) accession number: A8Z4E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health