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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NAD; via amide nitrogenUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei141NAD; via amide nitrogenUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1
Binding sitei256NADUniRule annotation1
Binding sitei282NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:USA300HOU_1411
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000803221 – 332Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST332

Structurei

3D structure databases

ProteinModelPortaliA8Z453
SMRiA8Z453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 257Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

A8Z453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITVFGMG SFGTALANVL AENGHDVLMW GKNQDAVDEL NTCHTNKKYL
60 70 80 90 100
KYAKLDVNII ATSDMTKAIQ FADIYLMALP TKAMREVASQ INDKLTSKKT
110 120 130 140 150
FIHVAKGIEN GTFKRVSEMI EDSISPEYNA GIGVLSGPSH AEEVVVKQPT
160 170 180 190 200
TVAASSKDKS VSKLTQDLFM NDYLRVYTND DLIGVELGGA LKNIIAVASG
210 220 230 240 250
IVAGIGYGDN AKAALMTRGL AEISRLGEKL GADPMTFLGL GGIGDLIVTC
260 270 280 290 300
TSTHSRNFTL GYKLGQGESM DQALSEMNMV VEGIYTTKSV YHLAKEKNVD
310 320 330
MPITNALYRV LFENISVKEC VKDLMERDKK SE
Length:332
Mass (Da):36,071
Last modified:January 15, 2008 - v1
Checksum:iF1D44E7E0DD002F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA Translation: ABX29421.1
RefSeqiWP_000161738.1, NC_010079.1

Genome annotation databases

EnsemblBacteriaiABX29421; ABX29421; USA300HOU_1411
KEGGisax:USA300HOU_1411

Similar proteinsi

Entry informationi

Entry nameiGPDA_STAAT
AccessioniPrimary (citable) accession number: A8Z453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health