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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51NucleophileUniRule annotation1
Binding sitei109SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:USA300HOU_2210
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000771071 – 267tRNA pseudouridine synthase AAdd BLAST267

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8Z326
SMRiA8Z326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248673
KOiK06173
OMAiFLYGMVR

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

A8Z326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILVEIAYQ GNNFLGFQIQ QNGRTVQQQF EKLLQRMHKR HVRIHPSSRT
60 70 80 90 100
DRGVHAIQQY FHFDTELNIP MSQWQYAMNR TLPDDIYVNN VVTVDDDFHC
110 120 130 140 150
RYDCVGKRYR YKVYQAQHRD PFQSGLKTFI PETLDLGKMN RAAQQFIGTH
160 170 180 190 200
DFTGFCSQKT EVESKVRTLY QSEIVKTDDG FDYIVTGSGF LYNMVRVLVA
210 220 230 240 250
FLIEVGKGRH EVSDVPKLLE SKNRKNVPFT APAEGLYLEK IYLDENELLK
260
DFGNDIKIHR KKSLQND
Length:267
Mass (Da):31,280
Last modified:January 15, 2008 - v1
Checksum:i2AB179F2CE0C0083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA Translation: ABX30203.1
RefSeqiWP_001221860.1, NC_010079.1

Genome annotation databases

EnsemblBacteriaiABX30203; ABX30203; USA300HOU_2210
KEGGisax:USA300HOU_2210

Similar proteinsi

Entry informationi

Entry nameiTRUA_STAAT
AccessioniPrimary (citable) accession number: A8Z326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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