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A8Z2Q0

- FTHS_STAAT

UniProt

A8Z2Q0 - FTHS_STAAT

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, USA300HOU_1721
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR451516:GJQ4-1742-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:USA300HOU_1721
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000793: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000333317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi451516.USA300HOU_1721.

Structurei

3D structure databases

ProteinModelPortaliA8Z2Q0.
SMRiA8Z2Q0. Positions 6-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z2Q0-1 [UniParc]FASTAAdd to Basket

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MTHLSDLDIA NQSTLQPIKD IAASVGISED ALEPYGHYKA KIDINKITPR    50
ENKGKVVLVT AMSPTPAGEG KSTVTVGLAD AFHELNKNVM VALREPALGP 100
TFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL SAFIDNHIHQ 150
GNELGIDQRR IEWKRVLDMN DRALRHVNVG LGGPTNGVPR EDGFNITVAS 200
EIMAILCLSR SIKDLKDKIS RITIGYTRDR KPVTVADLKV EGALAMILKD 250
AIKPNLVQSI EGTPALVHGG PFANIAHGCN SILATETARD LADIVVTEAG 300
FGSDLGAEKF MDIKVREAGF DPAAVVVVAT IRALKMHGGV AKDNLKEENV 350
EAVKAGIVNL ERHVNNIKKF GVEPVVAINA FIHDTDAEVE YVKSWAKENN 400
VRIALTEVWK KGGKGGVDLA NEVLEVIDQP NSFKPLYELE LPLEQKIEKI 450
VTEIYGGSKV TFSSKAQKQL KQFKENGWDN YPVCMAKTQY SFSDDQTLLG 500
APSGFEITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTDDGH 550
AIGLF 555
Length:555
Mass (Da):59,884
Last modified:May 20, 2008 - v2
Checksum:i75CAB62B84EB2A7D
GO

Sequence cautioni

The sequence ABX29728.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000730 Genomic DNA. Translation: ABX29728.1. Different initiation.
RefSeqiYP_001575607.1. NC_010079.1.

Genome annotation databases

EnsemblBacteriaiABX29728; ABX29728; USA300HOU_1721.
GeneIDi5775307.
KEGGisax:USA300HOU_1721.
PATRICi19598594. VBIStaAur36919_1818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000730 Genomic DNA. Translation: ABX29728.1 . Different initiation.
RefSeqi YP_001575607.1. NC_010079.1.

3D structure databases

ProteinModelPortali A8Z2Q0.
SMRi A8Z2Q0. Positions 6-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 451516.USA300HOU_1721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX29728 ; ABX29728 ; USA300HOU_1721 .
GeneIDi 5775307.
KEGGi sax:USA300HOU_1721.
PATRICi 19598594. VBIStaAur36919_1818.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SAUR451516:GJQ4-1742-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300 / TCH1516.

Entry informationi

Entry nameiFTHS_STAAT
AccessioniPrimary (citable) accession number: A8Z2Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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