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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:USA300HOU_1641
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000744431 – 200Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST200

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8Z2H0.
SMRiA8Z2H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000057116.
KOiK03550.
OMAiDCHGVGY.

Family and domain databases

CDDicd14332. UBA_RuvA_C. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA. 1 hit.
InterProiView protein in InterPro
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
IPR011114. RuvA_C.
IPR036267. RuvA_C_sf.
PANTHERiPTHR33796. PTHR33796. 1 hit.
PfamiView protein in Pfam
PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
SMARTiView protein in SMART
SM00278. HhH1. 2 hits.
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

A8Z2H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAYVKGKLT HLYPTHVVVE TAGVGYEIQT PNSYRFQKHL DHEVLIHTSL
60 70 80 90 100
IVREDAQLLY GFSSEEEKDM FLSLIKVTGI GPKSALAILA TSTPNEVKRA
110 120 130 140 150
IENENDTYLT KFPGIGKKTA RQIVLDLKGK VKITEEDSDS LLQVDATSTV
160 170 180 190 200
QDQFVQEAML ALEALGYSKR ELAKVEKTLN KNKYDSVDEA VKAGLQLVVS
Length:200
Mass (Da):22,262
Last modified:January 15, 2008 - v1
Checksum:i26C01F793C058574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA. Translation: ABX29648.1.
RefSeqiWP_000271547.1. NC_010079.1.

Genome annotation databases

EnsemblBacteriaiABX29648; ABX29648; USA300HOU_1641.
KEGGisax:USA300HOU_1641.

Similar proteinsi

Entry informationi

Entry nameiRUVA_STAAT
AccessioniPrimary (citable) accession number: A8Z2H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program