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A8Z0L8 (A8Z0L8_STAAT) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2 HAMAP MF_00108
MEP cytidylyltransferase 2 HAMAP MF_00108
Gene names
Name:ispD2 HAMAP MF_00108
Ordered Locus Names:USA300HOU_0266
OrganismStaphylococcus aureus (strain USA300 / TCH1516) [Complete proteome] [HAMAP] EMBL ABX28297.1
Taxonomic identifier451516 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site141Transition state stabilizer By similarity HAMAP MF_00108
Site221Transition state stabilizer By similarity HAMAP MF_00108
Site1601Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2171Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A8Z0L8 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: B19F7EA82D847A0F

FASTA23826,657
        10         20         30         40         50         60 
MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII IATPQQWMTH 

        70         80         90        100        110        120 
TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG INDDDVIVTH DAVRPFLTHR 

       130        140        150        160        170        180 
IIKENIQAAL EYGAVDTVID AIDTIVTSKD NQTIDAIPVR NEMYQGQTPQ SFNINLLKES 

       190        200        210        220        230 
YAQLSDEQKS ILSDACKIIV ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000730 Genomic DNA. Translation: ABX28297.1.
RefSeqYP_001574176.1. NC_010079.1.

3D structure databases

ProteinModelPortalA8Z0L8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8Z0L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000035339; EBSTAP00000034128; EBSTAG00000035337.
GeneID5776614.
GenomeReviewsGene locus USA300HOU_0266 in contig CP000730_GR.
KEGGsax:USA300HOU_0266.
PATRIC19595527. VBIStaAur36919_0300.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000024510.
HOGENOMHBG672839.
OMAREQQDFW.
ProtClustDBPRK00155.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8Z0L8_STAAT
AccessionPrimary (citable) accession number: A8Z0L8
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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