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Protein

Ribonucleoside-diphosphate reductase

Gene

nrdE

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

DNA replicationUniRule annotation

Enzyme and pathway databases

BioCyciSAUR451516:GJQ4-772-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:nrdEImported
Ordered Locus Names:USA300HOU_0755Imported
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)Imported
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000793 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi451516.USA300HOU_0755.

Structurei

3D structure databases

ProteinModelPortaliA8Z003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000246165.
KOiK00525.
OMAiIYFYTVT.
OrthoDBiEOG6J48HC.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Z003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTMEEKKYN HIELNNEVTK RREDGFFSLE KDQEALVAYL EEVKDKTIFF
60 70 80 90 100
DTEIERLRYL VDNDFYFNVF DIYSEADLIE ITDYAKSIPF NFASYMSASK
110 120 130 140 150
FFKDYALKTN DKSQYLEDYN QHVAIVALYL ANGNKAQAKQ FISAMVEQRY
160 170 180 190 200
QPATPTFLNA GRARRGELVS CFLLEVDDSL NSINFIDSTA KQLSKIGGGV
210 220 230 240 250
AINLSKLRAR GEAIKGIKGV AKGVLPIAKS LEGGFSYADQ LGQRPGAGAV
260 270 280 290 300
YLNIFHYDVE EFLDTKKVNA DEDLRLSTIS TGLIVPSKFF DLAKEGKDFY
310 320 330 340 350
MFAPHTVKEE YGVTLDDIDL EKYYDDMVAN PNVEKKKKNA REMLNLIAQT
360 370 380 390 400
QLQSGYPYLM FKDNANRVHP NSNIGQIKMS NLCTEIFQLQ ETSIINDYGI
410 420 430 440 450
EDEIKRDISC NLGSLNIVNV MESGKFRDSV HSGMDALTVV SDVANIQNAP
460 470 480 490 500
GVRKANSELH SVGLGVMNLH GYLAKNKIGY ESEEAKDFAN IFFMMMNFYS
510 520 530 540 550
IERSMEIAKE RGIKYQDFEK SDYANGKYFE FYTTQEFEPQ FEKVRELFDG
560 570 580 590 600
MAIPTSEDWK KLQQDVEQYG LYHAYRLAIA PTQSISYVQN ATSSVMPIVD
610 620 630 640 650
QIERRTYGNA ETFYPMPFLS PQTMWYYKSA FNTDQMKLID LIATIQTHID
660 670 680 690 700
QGISTILYVN SEISTRELAR LYVYAHYKGL KSLYYTRNKL LSVEECTSCS

I
Length:701
Mass (Da):80,126
Last modified:January 14, 2008 - v1
Checksum:iA8B49FE4A1B652B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA. Translation: ABX28776.1.
RefSeqiYP_001574655.1. NC_010079.1.

Genome annotation databases

EnsemblBacteriaiABX28776; ABX28776; USA300HOU_0755.
GeneIDi5777518.
KEGGisax:USA300HOU_0755.
PATRICi19596556. VBIStaAur36919_0797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA. Translation: ABX28776.1.
RefSeqiYP_001574655.1. NC_010079.1.

3D structure databases

ProteinModelPortaliA8Z003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi451516.USA300HOU_0755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX28776; ABX28776; USA300HOU_0755.
GeneIDi5777518.
KEGGisax:USA300HOU_0755.
PATRICi19596556. VBIStaAur36919_0797.

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000246165.
KOiK00525.
OMAiIYFYTVT.
OrthoDBiEOG6J48HC.

Enzyme and pathway databases

UniPathwayiUPA00326.
BioCyciSAUR451516:GJQ4-772-MONOMER.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: USA300 / TCH1516Imported.

Entry informationi

Entry nameiA8Z003_STAAT
AccessioniPrimary (citable) accession number: A8Z003
Entry historyi
Integrated into UniProtKB/TrEMBL: January 14, 2008
Last sequence update: January 14, 2008
Last modified: February 3, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.