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A8Z003

- A8Z003_STAAT

UniProt

A8Z003 - A8Z003_STAAT

Protein

Ribonucleoside-diphosphate reductase

Gene

nrdE

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    DNA replicationUniRule annotation

    Enzyme and pathway databases

    BioCyciSAUR451516:GJQ4-772-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
    Gene namesi
    Name:nrdEImported
    Ordered Locus Names:USA300HOU_0755Imported
    OrganismiStaphylococcus aureus (strain USA300 / TCH1516)Imported
    Taxonomic identifieri451516 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000793: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi451516.USA300HOU_0755.

    Structurei

    3D structure databases

    ProteinModelPortaliA8Z003.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0209.
    HOGENOMiHOG000246165.
    KOiK00525.
    OMAiIYYIRIR.
    OrthoDBiEOG6J48HC.

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR026459. RNR_1b_NrdE.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR013554. RNR_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    PF08343. RNR_N. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    SUPFAMiSSF48168. SSF48168. 1 hit.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
    TIGR04170. RNR_1b_NrdE. 1 hit.
    PROSITEiPS00089. RIBORED_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8Z003-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTMEEKKYN HIELNNEVTK RREDGFFSLE KDQEALVAYL EEVKDKTIFF    50
    DTEIERLRYL VDNDFYFNVF DIYSEADLIE ITDYAKSIPF NFASYMSASK 100
    FFKDYALKTN DKSQYLEDYN QHVAIVALYL ANGNKAQAKQ FISAMVEQRY 150
    QPATPTFLNA GRARRGELVS CFLLEVDDSL NSINFIDSTA KQLSKIGGGV 200
    AINLSKLRAR GEAIKGIKGV AKGVLPIAKS LEGGFSYADQ LGQRPGAGAV 250
    YLNIFHYDVE EFLDTKKVNA DEDLRLSTIS TGLIVPSKFF DLAKEGKDFY 300
    MFAPHTVKEE YGVTLDDIDL EKYYDDMVAN PNVEKKKKNA REMLNLIAQT 350
    QLQSGYPYLM FKDNANRVHP NSNIGQIKMS NLCTEIFQLQ ETSIINDYGI 400
    EDEIKRDISC NLGSLNIVNV MESGKFRDSV HSGMDALTVV SDVANIQNAP 450
    GVRKANSELH SVGLGVMNLH GYLAKNKIGY ESEEAKDFAN IFFMMMNFYS 500
    IERSMEIAKE RGIKYQDFEK SDYANGKYFE FYTTQEFEPQ FEKVRELFDG 550
    MAIPTSEDWK KLQQDVEQYG LYHAYRLAIA PTQSISYVQN ATSSVMPIVD 600
    QIERRTYGNA ETFYPMPFLS PQTMWYYKSA FNTDQMKLID LIATIQTHID 650
    QGISTILYVN SEISTRELAR LYVYAHYKGL KSLYYTRNKL LSVEECTSCS 700
    I 701
    Length:701
    Mass (Da):80,126
    Last modified:January 15, 2008 - v1
    Checksum:iA8B49FE4A1B652B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000730 Genomic DNA. Translation: ABX28776.1.
    RefSeqiYP_001574655.1. NC_010079.1.

    Genome annotation databases

    EnsemblBacteriaiABX28776; ABX28776; USA300HOU_0755.
    GeneIDi5777518.
    KEGGisax:USA300HOU_0755.
    PATRICi19596556. VBIStaAur36919_0797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000730 Genomic DNA. Translation: ABX28776.1 .
    RefSeqi YP_001574655.1. NC_010079.1.

    3D structure databases

    ProteinModelPortali A8Z003.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 451516.USA300HOU_0755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX28776 ; ABX28776 ; USA300HOU_0755 .
    GeneIDi 5777518.
    KEGGi sax:USA300HOU_0755.
    PATRICi 19596556. VBIStaAur36919_0797.

    Phylogenomic databases

    eggNOGi COG0209.
    HOGENOMi HOG000246165.
    KOi K00525.
    OMAi IYYIRIR.
    OrthoDBi EOG6J48HC.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci SAUR451516:GJQ4-772-MONOMER.

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR026459. RNR_1b_NrdE.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    IPR013554. RNR_N.
    IPR008926. RNR_R1-su_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    PF08343. RNR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    SUPFAMi SSF48168. SSF48168. 1 hit.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    TIGR04170. RNR_1b_NrdE. 1 hit.
    PROSITEi PS00089. RIBORED_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: USA300 / TCH1516Imported.

    Entry informationi

    Entry nameiA8Z003_STAAT
    AccessioniPrimary (citable) accession number: A8Z003
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3