A8YZN6 (RL1_STAAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1

Gene names

Name:	rplA
Ordered Locus Names:	USA300HOU_0532

Organism

Staphylococcus aureus (strain USA300 / TCH1516) [Complete proteome] [HAMAP]

Taxonomic identifier

451516 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release By similarity. HAMAP MF_01318_B Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA By similarity. HAMAP MF_01318_B
Subunit structure	Part of the 50S ribosomal subunit By similarity. HAMAP MF_01318_B
Sequence similarities	Belongs to the ribosomal protein L1P family.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: InterPro
Cellular component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	50S ribosomal protein L1 HAMAP MF_01318_B		PRO_1000086312

Sequences

	Sequence		Length	Mass (Da)
	A8YZN6 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 0A1DD057E8A89EA6	FASTA	230	24,708
	10 20 30 40 50 60 MAKKGKKYQE AASKVDRTQH YSVEEAIKLA KETSIANFDA SVEVAFRLGI DTRKNDQQIR 70 80 90 100 110 120 GAVVLPNGTG KSQSVLVFAK GDKIAEAEAA GADYVGEAEY VQKIQQGWFD FDVVVATPDM 130 140 150 160 170 180 MGEVGKLGRV LGPKGLMPNP KTGTVTMDVK KAVEEIKAGK VEYRAEKAGI VHASIGKVSF 190 200 210 220 230 TDEQLIENFN TLQDVLAKAK PSSAKGTYFK SVAVTTTMGP GVKIDTASFK

References

[1]

"Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus." Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S., Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O., Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M., Hemphill L. , Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H., Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V., Wang Q., Zhou J., Kaplan S.L., Weinstock G.M. BMC Microbiol. 7:99-99(2007) [PubMed: 17986343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USA300 / TCH1516.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000730 Genomic DNA. Translation: ABX28558.1.
RefSeq	YP_001574437.1. NC_010079.1.
3D structure databases
ProteinModelPortal	A8YZN6.
SMR	A8YZN6. Positions 6-228.
ModBase	Search...
Protein-protein interaction databases
STRING	A8YZN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000033668; EBSTAP00000032457; EBSTAG00000033666.
GeneID	5776824.
GenomeReviews	Gene locus USA300HOU_0532 in contig CP000730_GR.
KEGG	sax:USA300HOU_0532.
PATRIC	19596111. VBIStaAur36919_0575.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000024312.
HOGENOM	HBG297400.
OMA	KAGTVTM.
ProtClustDB	PRK05424.
Family and domain databases
HAMAP	MF_01318_B. Ribosomal_L1_B. [Tree]
InterPro	IPR005878. Ribosom_L1_bac-type. IPR002143. Ribosomal_L1. IPR016094. Ribosomal_L1_2-a/b-sand. IPR016095. Ribosomal_L1_3-a/b-sand. IPR023673. Ribosomal_L1_CS. IPR023674. Ribosomal_L1_SF. [Graphical view]
Gene3D	G3DSA:3.30.190.20. Ribosomal_L1_2-a/b-sand. 2 hits. G3DSA:3.40.50.790. Ribosomal_L1_3-a/b-sand. 1 hit.
KO	K02863.
Pfam	PF00687. Ribosomal_L1. 1 hit. [Graphical view]
PIRSF	PIRSF002155. Ribosomal_L1. 1 hit.
SUPFAM	SSF56808. Ribosomal_L1. 1 hit.
TIGRFAMs	TIGR01169. RplA_bact. 1 hit.
PROSITE	PS01199. RIBOSOMAL_L1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL1_STAAT

Accession

Primary (citable) accession number: A8YZN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program