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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei87Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:USA300HOU_2398
OrganismiStaphylococcus aureus (strain USA300 / TCH1516)
Taxonomic identifieri451516 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000843331 – 2282,3-bisphosphoglycerate-dependent phosphoglycerate mutaseAdd BLAST228

Structurei

3D structure databases

ProteinModelPortaliA8YYG4
SMRiA8YYG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni114 – 115Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.12401 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

A8YYG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLILCRHG QSEWNAKNLF TGWEDVNLSE QGINEATRAG EKVRENNIAI
60 70 80 90 100
DVAFTSLLTR ALDTTHYILT ESKQQWIPVY KSWRLNERHY GGLQGLNKDD
110 120 130 140 150
ARKEFGEEQV HIWRRSYDVK PPAETEEQRE AYLADRRYNH LDKRMMPYSE
160 170 180 190 200
SLKDTLVRVI PFWTDHISQY LLDGQTVLVS AHGNSIRALI KYLEDVSDED
210 220
IINYEIKTGA PLVYELTDDL EVIDKYYL
Length:228
Mass (Da):26,680
Last modified:January 15, 2008 - v1
Checksum:i1751F3AFB1EE068E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000730 Genomic DNA Translation: ABX30388.1
RefSeqiWP_001125208.1, NC_010079.1

Genome annotation databases

EnsemblBacteriaiABX30388; ABX30388; USA300HOU_2398
KEGGisax:USA300HOU_2398

Similar proteinsi

Entry informationi

Entry nameiGPMA_STAAT
AccessioniPrimary (citable) accession number: A8YYG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program