A8YXM7 (IF1_LACH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-1

Gene names

Name:	infA
Ordered Locus Names:	lhv_0334

Organism

Lactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]

Taxonomic identifier

405566 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus helveticus

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	No specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 By similarity. HAMAP-Rule MF_00075
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IF-1 family. Contains 1 S1-like domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 73	73	Translation initiation factor IF-1 HAMAP-Rule MF_00075		PRO_0000338847
Regions
	Domain	1 – 72	72	S1-like

Sequences

	Sequence		Length	Mass (Da)
	A8YXM7 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: A1A02563EB0CFC62	FASTA	73	8,274
	10 20 30 40 50 60 MAKDDVIEVE GKVVDTLPNA MFKVELENGA TILAHVSGKI RMHYIRILPG DRVTVELSPY 70 DLTKGRITYR FIK

References

[1]

"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion." Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P. J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DPC 4571.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000517 Genomic DNA. Translation: ABX26558.1.
RefSeq	YP_001576849.1. NC_010080.1.
3D structure databases
ProteinModelPortal	A8YXM7.
SMR	A8YXM7. Positions 2-70.
ModBase	Search...
Protein-protein interaction databases
STRING	405566.lhv_0334.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABX26558; ABX26558; lhv_0334.
GeneID	5772472.
KEGG	lhe:lhv_0334.
PATRIC	22232686. VBILacHel91643_0346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0361.
HOGENOM	HOG000221323.
KO	K02518.
OMA	MRMNYIK.
ProtClustDB	PRK00276.
Enzyme and pathway databases
BioCyc	LHEL405566:GJEN-299-MONOMER.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_00075. IF-1.
InterPro	IPR012340. NA-bd_OB-fold. IPR022967. RNA-binding_domain_S1. IPR006196. RNA-binding_domain_S1_IF1. IPR004368. TIF_IF1. [Graphical view]
Pfam	PF01176. eIF-1a. 1 hit. [Graphical view]
SMART	SM00316. S1. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00008. infA. 1 hit.
PROSITE	PS50832. S1_IF1_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF1_LACH4

Accession

Primary (citable) accession number: A8YXM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program