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A8YWU4

- SYL_LACH4

UniProt

A8YWU4 - SYL_LACH4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei576 – 5761ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLHEL405566:GJEN-1513-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:lhv_1726
    OrganismiLactobacillus helveticus (strain DPC 4571)
    Taxonomic identifieri405566 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000790: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_1000091328Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405566.lhv_1726.

    Structurei

    3D structure databases

    ProteinModelPortaliA8YWU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 5012"HIGH" regionAdd
    BLAST
    Motifi573 – 5775"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8YWU4-1 [UniParc]FASTAAdd to Basket

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    MYNHKVVEKK WQDYWAKHDT FKTGTDPKKK NYYALDMFPF PSGKGLHVGH    50
    PEGYTATDIV SRMKRAQGYN VLHPMGWDAF GLPTEQYALK TGEDPAVVTK 100
    NNIANFKRQL NKLGFSYDWD REITTSDPNY YKWTQWVFEQ MYKKGLAYEA 150
    EVPVNWSPDL GTVVANEEVI DGKTERGGYP VYRRNMRQWM LKMTAYADRL 200
    LEDLDDLDWP EPVKEMQRNW IGRSVGAQVT FKIKDSDKTF DIFTTRPDTL 250
    FGCSYTVLAP ENKLVQEITT DGHRDEVNAY IKKIESKSDL ERTDLNKDKT 300
    GVFTGAYAIN PVNGKEVPIW ISDYVLASYG TGAVMAVPAH DDRDYAFAKK 350
    FDLPINQVLE GGDLSKAAFT EDGPHINSEF LNGLNIKDAK KKMVDWLEEH 400
    NCGEKKVNYK LRDWDFSRQR YWGEPIPVIH WEDGTTSLVP EDQLPLRLPH 450
    ATDIKPSGTP ESPLANLTDW VNVVDEMGRK GKRETNTMPN WAGSSWYYLR 500
    YVDPHNDKEL ADYDLLKQWL PVDLYIGGAE HAVRHLLYAR FWHKVLYDLG 550
    VVPTKEPFQR LYNQGLILKN HEKMSKSKGN VVNPDEVIDE YGADSLRMYE 600
    MFMGPLDASI DWDDNGPAST KKFLDRVWRL FVNDLDLKAI PQERIVDKND 650
    GELDKVYAET VKKVTEDFDA LHFNTAISQM MVFINAAQKA KTIPREYVEG 700
    FVKLLAPVAP HMMEEIWQVF GHDESITYAK WPTYDPAKLV ESTVEIMVQV 750
    NGKLRGKFEA AKDADRDDVQ KQAMALPHVQ KFLEGKDVKK VIVVPNKIVN 800
    IVAK 804
    Length:804
    Mass (Da):92,396
    Last modified:January 15, 2008 - v1
    Checksum:i430DC21235A47AEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000517 Genomic DNA. Translation: ABX27605.1.
    RefSeqiYP_001577906.1. NC_010080.1.

    Genome annotation databases

    EnsemblBacteriaiABX27605; ABX27605; lhv_1726.
    GeneIDi5771243.
    KEGGilhe:lhv_1726.
    PATRICi22235748. VBILacHel91643_1822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000517 Genomic DNA. Translation: ABX27605.1 .
    RefSeqi YP_001577906.1. NC_010080.1.

    3D structure databases

    ProteinModelPortali A8YWU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405566.lhv_1726.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX27605 ; ABX27605 ; lhv_1726 .
    GeneIDi 5771243.
    KEGGi lhe:lhv_1726.
    PATRICi 22235748. VBILacHel91643_1822.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LHEL405566:GJEN-1513-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
      Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
      J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DPC 4571.

    Entry informationi

    Entry nameiSYL_LACH4
    AccessioniPrimary (citable) accession number: A8YWU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3