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A8YW74 (RTPR_LACH4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:lhv_0042
OrganismLactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]
Taxonomic identifier405566 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326542

Regions

Region148 – 15912Effector region-1 By similarity
Region169 – 318150Effector region-2 By similarity
Region570 – 63162Adenosylcobalamin-binding-1 By similarity
Region690 – 72940Adenosylcobalamin-binding-2 By similarity

Sites

Active site4131 By similarity
Active site4151 By similarity

Amino acid modifications

Disulfide bond120 ↔ 424Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
A8YW74 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: F4B8613B6264A290

FASTA74483,183
        10         20         30         40         50         60 
MPATRITLDS TFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRTENWD ETVKRVIEGN 

        70         80         90        100        110        120 
INLDPRLQDL PSQDVIDKLT NEAQQLFRLV YSLSATPSGR NLWISGTDYQ KRNGDSLNNC 

       130        140        150        160        170        180 
WFIAIRPQAY GDSHIVPTYI DKRKEAVSMP FSFLFDQLMK GGGVGFSVVD DNINQIPQVD 

       190        200        210        220        230        240 
HQVDLSVVID KNSKSYDASL KVGAIDKAEW EKNNSGLDNV IYYRIPDTRE GWVLANARLI 

       250        260        270        280        290        300 
DLHFNDTNPD QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFFDIN NVINERVGQK 

       310        320        330        340        350        360 
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSDNQDFIK MKQDKEKLYH HRWASNNSVA 

       370        380        390        400        410        420 
INSKFNNYGP IADGIMHNGE PGIVNLDLSR NYGRIADGYQ AGIDDDVEGT NPCGEISLAN 

       430        440        450        460        470        480 
GEPCNLFEVF PYIAEQQGWD LKEAFSLAAR YTKRVTFSHY DWEVSRNIIQ KNRRIGVSMS 

       490        500        510        520        530        540 
GIQDWLLNDL GHRVVTGFKD ATDKETGAPI KKPIYDPQGI KMVDGLYHAV IAADKAYSEE 

       550        560        570        580        590        600 
LGVNPSIKHT TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALRKCGYHTE 

       610        620        630        640        650        660 
PDIYTKNTIC VEIPLRAAHA DSKNFASAGT VSIAEQFATQ AFLQTYWSDN AVSCTVTFQA 

       670        680        690        700        710        720 
NESNQIAPLL HQYRHTIKST SLLPYYGGSL KQAPKEPINK KAYEDRVAMI TGDVKEVFEN 

       730        740 
QNKDQKGLEL VDQSDCTSGA CPIK 

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References

[1]"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DPC 4571.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000517 Genomic DNA. Translation: ABX26329.1.
RefSeqYP_001576616.1. NC_010080.1.

3D structure databases

ProteinModelPortalA8YW74.
SMRA8YW74. Positions 6-729.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405566.lhv_0042.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX26329; ABX26329; lhv_0042.
GeneID5772754.
KEGGlhe:lhv_0042.
PATRIC22232056. VBILacHel91643_0045.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00527.
OMADSLNNCW.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLHEL405566:GJEN-38-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACH4
AccessionPrimary (citable) accession number: A8YW74
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families