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A8YW74

- RTPR_LACH4

UniProt

A8YW74 - RTPR_LACH4

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131By similarity
    Active sitei415 – 4151By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciLHEL405566:GJEN-38-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:lhv_0042
    OrganismiLactobacillus helveticus (strain DPC 4571)
    Taxonomic identifieri405566 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000790: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi120 ↔ 424Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi405566.lhv_0042.

    Structurei

    3D structure databases

    ProteinModelPortaliA8YW74.
    SMRiA8YW74. Positions 6-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni148 – 15912Effector region-1By similarityAdd
    BLAST
    Regioni169 – 318150Effector region-2By similarityAdd
    BLAST
    Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000068540.
    KOiK00527.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8YW74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPATRITLDS TFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRTENWD    50
    ETVKRVIEGN INLDPRLQDL PSQDVIDKLT NEAQQLFRLV YSLSATPSGR 100
    NLWISGTDYQ KRNGDSLNNC WFIAIRPQAY GDSHIVPTYI DKRKEAVSMP 150
    FSFLFDQLMK GGGVGFSVVD DNINQIPQVD HQVDLSVVID KNSKSYDASL 200
    KVGAIDKAEW EKNNSGLDNV IYYRIPDTRE GWVLANARLI DLHFNDTNPD 250
    QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFFDIN NVINERVGQK 300
    LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSDNQDFIK MKQDKEKLYH 350
    HRWASNNSVA INSKFNNYGP IADGIMHNGE PGIVNLDLSR NYGRIADGYQ 400
    AGIDDDVEGT NPCGEISLAN GEPCNLFEVF PYIAEQQGWD LKEAFSLAAR 450
    YTKRVTFSHY DWEVSRNIIQ KNRRIGVSMS GIQDWLLNDL GHRVVTGFKD 500
    ATDKETGAPI KKPIYDPQGI KMVDGLYHAV IAADKAYSEE LGVNPSIKHT 550
    TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALRKCGYHTE 600
    PDIYTKNTIC VEIPLRAAHA DSKNFASAGT VSIAEQFATQ AFLQTYWSDN 650
    AVSCTVTFQA NESNQIAPLL HQYRHTIKST SLLPYYGGSL KQAPKEPINK 700
    KAYEDRVAMI TGDVKEVFEN QNKDQKGLEL VDQSDCTSGA CPIK 744
    Length:744
    Mass (Da):83,183
    Last modified:January 15, 2008 - v1
    Checksum:iF4B8613B6264A290
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000517 Genomic DNA. Translation: ABX26329.1.
    RefSeqiWP_012211218.1. NC_010080.1.
    YP_001576616.1. NC_010080.1.

    Genome annotation databases

    EnsemblBacteriaiABX26329; ABX26329; lhv_0042.
    GeneIDi5772754.
    KEGGilhe:lhv_0042.
    PATRICi22232056. VBILacHel91643_0045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000517 Genomic DNA. Translation: ABX26329.1 .
    RefSeqi WP_012211218.1. NC_010080.1.
    YP_001576616.1. NC_010080.1.

    3D structure databases

    ProteinModelPortali A8YW74.
    SMRi A8YW74. Positions 6-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405566.lhv_0042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABX26329 ; ABX26329 ; lhv_0042 .
    GeneIDi 5772754.
    KEGGi lhe:lhv_0042.
    PATRICi 22232056. VBILacHel91643_0045.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000068540.
    KOi K00527.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci LHEL405566:GJEN-38-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
      Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
      J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DPC 4571.

    Entry informationi

    Entry nameiRTPR_LACH4
    AccessioniPrimary (citable) accession number: A8YW74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3