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A8YW74

- RTPR_LACH4

UniProt

A8YW74 - RTPR_LACH4

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin.By similarity

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei413 – 4131By similarity
Active sitei415 – 4151By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciLHEL405566:GJEN-38-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:lhv_0042
OrganismiLactobacillus helveticus (strain DPC 4571)
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000790: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 424Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi405566.lhv_0042.

Structurei

3D structure databases

ProteinModelPortaliA8YW74.
SMRiA8YW74. Positions 6-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 15912Effector region-1By similarityAdd
BLAST
Regioni169 – 318150Effector region-2By similarityAdd
BLAST
Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
BLAST
Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG1372.
HOGENOMiHOG000068540.
KOiK00527.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

A8YW74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPATRITLDS TFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRTENWD
60 70 80 90 100
ETVKRVIEGN INLDPRLQDL PSQDVIDKLT NEAQQLFRLV YSLSATPSGR
110 120 130 140 150
NLWISGTDYQ KRNGDSLNNC WFIAIRPQAY GDSHIVPTYI DKRKEAVSMP
160 170 180 190 200
FSFLFDQLMK GGGVGFSVVD DNINQIPQVD HQVDLSVVID KNSKSYDASL
210 220 230 240 250
KVGAIDKAEW EKNNSGLDNV IYYRIPDTRE GWVLANARLI DLHFNDTNPD
260 270 280 290 300
QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFFDIN NVINERVGQK
310 320 330 340 350
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSSDNQDFIK MKQDKEKLYH
360 370 380 390 400
HRWASNNSVA INSKFNNYGP IADGIMHNGE PGIVNLDLSR NYGRIADGYQ
410 420 430 440 450
AGIDDDVEGT NPCGEISLAN GEPCNLFEVF PYIAEQQGWD LKEAFSLAAR
460 470 480 490 500
YTKRVTFSHY DWEVSRNIIQ KNRRIGVSMS GIQDWLLNDL GHRVVTGFKD
510 520 530 540 550
ATDKETGAPI KKPIYDPQGI KMVDGLYHAV IAADKAYSEE LGVNPSIKHT
560 570 580 590 600
TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALRKCGYHTE
610 620 630 640 650
PDIYTKNTIC VEIPLRAAHA DSKNFASAGT VSIAEQFATQ AFLQTYWSDN
660 670 680 690 700
AVSCTVTFQA NESNQIAPLL HQYRHTIKST SLLPYYGGSL KQAPKEPINK
710 720 730 740
KAYEDRVAMI TGDVKEVFEN QNKDQKGLEL VDQSDCTSGA CPIK
Length:744
Mass (Da):83,183
Last modified:January 15, 2008 - v1
Checksum:iF4B8613B6264A290
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000517 Genomic DNA. Translation: ABX26329.1.
RefSeqiYP_001576616.1. NC_010080.1.

Genome annotation databases

EnsemblBacteriaiABX26329; ABX26329; lhv_0042.
GeneIDi5772754.
KEGGilhe:lhv_0042.
PATRICi22232056. VBILacHel91643_0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000517 Genomic DNA. Translation: ABX26329.1 .
RefSeqi YP_001576616.1. NC_010080.1.

3D structure databases

ProteinModelPortali A8YW74.
SMRi A8YW74. Positions 6-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405566.lhv_0042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX26329 ; ABX26329 ; lhv_0042 .
GeneIDi 5772754.
KEGGi lhe:lhv_0042.
PATRICi 22232056. VBILacHel91643_0045.

Phylogenomic databases

eggNOGi COG1372.
HOGENOMi HOG000068540.
KOi K00527.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Enzyme and pathway databases

BioCyci LHEL405566:GJEN-38-MONOMER.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
    Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
    J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DPC 4571.

Entry informationi

Entry nameiRTPR_LACH4
AccessioniPrimary (citable) accession number: A8YW74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3