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Protein

16S rRNA (cytosine(967)-C(5))-methyltransferase

Gene

lhv_1404

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei295S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei323S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei342S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei395NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
16S rRNA (cytosine(967)-C(5))-methyltransferaseSAAS annotation (EC:2.1.1.176SAAS annotation)
Gene namesi
Ordered Locus Names:lhv_1404Imported
OrganismiLactobacillus helveticus (strain DPC 4571)Imported
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000790 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi405566.lhv_1404.

Structurei

3D structure databases

ProteinModelPortaliA8YVW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 453SAM_MT_RSMB_NOPInterPro annotationAdd BLAST271

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiLRVNRQH.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
InterProiView protein in InterPro
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

A8YVW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAASLPQE KKLSTNKSAR AISLETLIKV LQNGSYSNIS LNNSLKHSDL
60 70 80 90 100
SIADQNLATR IVYGTIQYRL FLEYQLTGLL KTKITEKYLK PLLLMSLYQI
110 120 130 140 150
IFLDKVPNRA VLDEANKLAK QFGKHHSSGY RVVNGILRAF IRRGVILPDE
160 170 180 190 200
KDTIKYLSIK ESVPEWLVKY LIDNWGMQKA QSVLSSINDP AKNSVRISSL
210 220 230 240 250
ADRNKVFDQL KKEGYQPEWS NLSLNDAVLS HGGISESDLF EQGKLIIQDE
260 270 280 290 300
AASLVVEAFD FDQNQTEHVL DACSAPGGKT VQIAENIHGD VTALDIHEKK
310 320 330 340 350
LRLVKENARR MHVLDKVTTK ACDARKAHEI FKAGEFTKIL VDAPCSGLGL
360 370 380 390 400
LRRKPEIRYT KSLQDLRNLQ KIQLTILDSI SKLLKAEGEL VYSTCSISME
410 420 430 440 450
ENEEVVKRFL RIHPGFELKP FSLSKLESKT GMLKIMPDQD GNDGFFIAKF

RLRG
Length:454
Mass (Da):51,173
Last modified:January 15, 2008 - v1
Checksum:i66F16D661A313035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000517 Genomic DNA. Translation: ABX27391.1.

Genome annotation databases

EnsemblBacteriaiABX27391; ABX27391; lhv_1404.
KEGGilhe:lhv_1404.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA8YVW1_LACH4
AccessioniPrimary (citable) accession number: A8YVW1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported