A8YVI9 (A8YVI9_LACH4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 1 HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase 1 HAMAP MF_01543

Gene names

Name:	fhs1 HAMAP MF_01543
Ordered Locus Names:	lhv_1260

Organism

Lactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]

Taxonomic identifier

405566 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS000559
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS000559
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS000559
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS000559 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS000559 EMBL ABX27276.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A8YVI9 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: F6DC1088AA23487F	FASTA	558	60,653
	10 20 30 40 50 60 MKSDIEIAQE TKELPIKEIA AKVNLKEEDL EPYGYDKAKI NWQAINRISK SKKLGKLILV 70 80 90 100 110 120 TSISPTPAGE GKSTITIGLG DAINNQLHKN TMIALREPSM GPVFGLKGGA TGGGMAQIIP 130 140 150 160 170 180 MEDINLHFTG DMHALTAAID TLAALVDNYI YQDNSLNIDP ERILLKRGLD VNDRALRNIT 190 200 210 220 230 240 VGQGSKFNGI EHKSSFAITV ANELMAILCL ATDIDDLKAR IGDMLVGYTK DDQPVYVKQL 250 260 270 280 290 300 GFQGAIAALL SNALKPNLVQ TLEHTPALVH GGPFANIAHG ANSVMATNLA LHLSDYVLTE 310 320 330 340 350 360 AGFGSDLGGQ KFIDFVSKHL DKQPDAAVVV ATVRALKYQA LRDTKHLDEE NLTALKAGFK 370 380 390 400 410 420 NLERHMNNMR SYNVPVVVLI NQFASDTEAE LDLLKKLIEE QNIPAEVVAY HDEGSKGGIE 430 440 450 460 470 480 AAQTVIDLAN SNKANIVSTY DEDDDVKNKI EKVATKIYHA SGVKYTEKAN KQIDELIKLG 490 500 510 520 530 540 KEKLPVIIAK TQYSFSDDKK QLGAPTDFKL HVRGVSLKNG ARFIVVTTGH VLDMPGLPKH 550 PAALDIDVDN NGKISGLF

References

[1]

"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion." Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P. J. Bacteriol. 190:727-735(2008) [PubMed: 17993529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000517 Genomic DNA. Translation: ABX27276.1.
RefSeq	YP_001577567.1. NC_010080.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8YVI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5771630.
GenomeReviews	Gene locus lhv_1260 in contig CP000517_GR.
KEGG	lhe:lhv_1260.
PATRIC	22234760. VBILacHel91643_1331.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	PERILLK.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8YVI9_LACH4

Accession

Primary (citable) accession number: A8YVI9

Entry history

Integrated into UniProtKB/TrEMBL:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)