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A8YVD9 (CAPP_LACH4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppc
Ordered Locus Names:lhv_1193
OrganismLactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]
Taxonomic identifier405566 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00595

Sequence similarities

Belongs to the PEPCase type 1 family.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 912912Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
PRO_1000072623

Sites

Active site1381 By similarity
Active site5751 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8YVD9 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 02ED016883C51F17

FASTA912104,678
        10         20         30         40         50         60 
MTVKKLENSS DVNVVTEEVK ILTNLLNEST EQLIGKELFT KIQNLIKISA DKNYQELEDQ 

        70         80         90        100        110        120 
IASLDNREMI VVARYFATLP LLINISEDVE LASKVNVLNN TNQDYLGKLN DTIDIVAQKK 

       130        140        150        160        170        180 
NAKEILEKVN VVPVLTAHPT QVQRKTVLEL TDKIHKLLRN YREVKNGIIT RVEWTEELRA 

       190        200        210        220        230        240 
CIEILMQTDI IRSHKLKVSN EITNVLTYYP KSLIPAITKF TARYKELAKK HGLDIPDATP 

       250        260        270        280        290        300 
ITMGMWIGGD RDGNPYVTAD TLKLSATLQG QVIFEYYIKQ INQLYRSISL STSYMKPSTE 

       310        320        330        340        350        360 
VMHLSELSND DSPFRTNEPY RRAFYYIESR LVRSEQKLLN ITNQHSFLKE RDLEHLDQIP 

       370        380        390        400        410        420 
AYEDAQEFKA DLEVIKRSLE ENRDQAVVKS YFTEILEAID VFGFHLATID MRQDSSVNEA 

       430        440        450        460        470        480 
CVAELLKSAE ICDHYSELSE KEKVSLLLNE LNNDPRNLHT NNKPKSELLQ KELKIYKTAR 

       490        500        510        520        530        540 
DLKDRLGEDL IKQHIISHTE SVSDMLEQAI MLKEYDLLDN QSARVQVVPL FETVEDLNNA 

       550        560        570        580        590        600 
RDIIKEYLNL DIVKKWLVSQ HNYQEVMLGY SDSNKDGGYL ASCWNLYKAQ KDLTAIGEEL 

       610        620        630        640        650        660 
GIKITYMHGR GGTVGRGGGP SYEAITAQPF NSINDRIRMT EQGEIIQNKY GNKDAAYYNL 

       670        680        690        700        710        720 
EMLVSATVDR IASKQIVSEE YIADFRSSMD KIVTESNEIY KKLVFENPNF LDYFLQATPI 

       730        740        750        760        770        780 
KEISNLNIGS RPASRKKLSD FSSLRAIPWV FSWSQSRVMF PGWYGVGSAF KHFIDADKKN 

       790        800        810        820        830        840 
LQELQHMYQG WPFFHALLSN ADMVLSKSNM EIAKQYAELC QDEKTKSVFD IIYQEWKLTK 

       850        860        870        880        890        900 
QIILQIEGHD DLLSDAPNLK NSLASRMPYF NILNYIQLEM IKRDREDEIK GVFQSIIPIT 

       910 
INGVASGLRN SG 

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References

[1]"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DPC 4571.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000517 Genomic DNA. Translation: ABX27226.1.
RefSeqYP_001577517.1. NC_010080.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405566.lhv_1193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABX27226; ABX27226; lhv_1193.
GeneID5771682.
KEGGlhe:lhv_1193.
PATRIC22234610. VBILacHel91643_1256.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2352.
HOGENOMHOG000238647.
KOK01595.
OMAIDIVAQK.
OrthoDBEOG6TJ7T8.

Enzyme and pathway databases

BioCycLHEL405566:GJEN-1080-MONOMER.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. SSF51621. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPP_LACH4
AccessionPrimary (citable) accession number: A8YVD9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families