SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8YUJ0

- A8YUJ0_LACH4

UniProt

A8YUJ0 - A8YUJ0_LACH4

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidine kinase

Gene
tdk, lhv_0801
Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptor By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi154 – 1541Zinc By similarityUniRule annotation
Metal bindingi188 – 1881Zinc By similarityUniRule annotation
Metal bindingi191 – 1911Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi93 – 964ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLHEL405566:GJEN-749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:lhv_0801Imported
OrganismiLactobacillus helveticus (strain DPC 4571)Imported
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000790: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi405566.lhv_0801.

Structurei

3D structure databases

ProteinModelPortaliA8YUJ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiAIPITAD.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8YUJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MSQLFFRYGA MSSGKTIEIL KVAHNYEAQG RKIALMTSGL DNRSGVGTVA    50
SRIGLHRKAI PITADMNLYT YIEKMNSHDL ADGKGKLACV LIDEAQFLKR 100
HHVLECAKIV DEFNIPVMAF GLKNDFQNHL FEGSENLLIF ADKIEEMKTI 150
CHYCGHKATM NLRVNNGKPV YEGEQVQIGG DESYYPVCRY HYFHPGIQR 199
Length:199
Mass (Da):22,518
Last modified:January 15, 2008 - v1
Checksum:iCA17E88399FDD017
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000517 Genomic DNA. Translation: ABX26928.1.
RefSeqiYP_001577219.1. NC_010080.1.

Genome annotation databases

EnsemblBacteriaiABX26928; ABX26928; lhv_0801.
GeneIDi5771999.
KEGGilhe:lhv_0801.
PATRICi22233758. VBILacHel91643_0833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000517 Genomic DNA. Translation: ABX26928.1 .
RefSeqi YP_001577219.1. NC_010080.1.

3D structure databases

ProteinModelPortali A8YUJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405566.lhv_0801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABX26928 ; ABX26928 ; lhv_0801 .
GeneIDi 5771999.
KEGGi lhe:lhv_0801.
PATRICi 22233758. VBILacHel91643_0833.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi AIPITAD.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci LHEL405566:GJEN-749-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
    Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
    J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DPC 4571Imported.

Entry informationi

Entry nameiA8YUJ0_LACH4
AccessioniPrimary (citable) accession number: A8YUJ0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi