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Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi154ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1
Metal bindingi191ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:lhv_0801Imported
OrganismiLactobacillus helveticus (strain DPC 4571)Imported
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000790 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405566.lhv_0801

Structurei

3D structure databases

ProteinModelPortaliA8YUJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A8YUJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLFFRYGA MSSGKTIEIL KVAHNYEAQG RKIALMTSGL DNRSGVGTVA
60 70 80 90 100
SRIGLHRKAI PITADMNLYT YIEKMNSHDL ADGKGKLACV LIDEAQFLKR
110 120 130 140 150
HHVLECAKIV DEFNIPVMAF GLKNDFQNHL FEGSENLLIF ADKIEEMKTI
160 170 180 190
CHYCGHKATM NLRVNNGKPV YEGEQVQIGG DESYYPVCRY HYFHPGIQR
Length:199
Mass (Da):22,518
Last modified:January 15, 2008 - v1
Checksum:iCA17E88399FDD017
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000517 Genomic DNA Translation: ABX26928.1
RefSeqiWP_003626146.1, NC_010080.1

Genome annotation databases

EnsemblBacteriaiABX26928; ABX26928; lhv_0801
KEGGilhe:lhv_0801

Similar proteinsi

Entry informationi

Entry nameiA8YUJ0_LACH4
AccessioniPrimary (citable) accession number: A8YUJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health