A8YUA3 (PPNK_LACH4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	lhv_0694

Organism

Lactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]

Taxonomic identifier

405566 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000072084

Sequences

	Sequence		Length	Mass (Da)
	A8YUA3 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 4A6B3B1B687F93B6	FASTA	270	30,742
	10 20 30 40 50 60 MKVTIAHNNY DKTLETVAYL KKLLQKKNVI FDAKYPDIVI TVGGDGTLIN AFHRYENQVD 70 80 90 100 110 120 SVRFIGVHTG HLGFYTDWRN YDIDKMVDAL LLTKGQPAKY PLLEIKMLTE SGDTRYHLAV 130 140 150 160 170 180 NESAVKRISH TLEADVYIDD ELFENFRGDG LCVSTPTGST AYSKSLGGAV IHPRLKALQM 190 200 210 220 230 240 TEIASINNRV FRTLSAPIVI APDQWITIVP NVDHFVMTVD GARIDVRNAK KIEYRISKHS 250 260 270 IQFDQFGHHH FWSRVQNAFI KDTEDNDKFI

References

[1]

"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion." Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P. J. Bacteriol. 190:727-735(2008) [PubMed: 17993529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DPC 4571.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000517 Genomic DNA. Translation: ABX26841.1.
RefSeq	YP_001577132.1. NC_010080.1.
3D structure databases
ProteinModelPortal	A8YUA3.
ModBase	Search...
Protein-protein interaction databases
STRING	A8YUA3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5772105.
GenomeReviews	Gene locus lhv_0694 in contig CP000517_GR.
KEGG	lhe:lhv_0694.
PATRIC	22233529. VBILacHel91643_0722.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG314020.
OMA	TISFANC.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	LHEL405566:LHV_0694-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_LACH4

Accession

Primary (citable) accession number: A8YUA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program