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Protein

Glutamate racemase

Gene

murI

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton donor/acceptorUniRule annotation
Active sitei183 – 1831Proton donor/acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciLHEL405566:GJEN-404-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:lhv_0449
OrganismiLactobacillus helveticus (strain DPC 4571)
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000790 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Glutamate racemasePRO_1000071882Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405566.lhv_0449.

Structurei

3D structure databases

ProteinModelPortaliA8YTR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate bindingUniRule annotation
Regioni42 – 432Substrate bindingUniRule annotation
Regioni74 – 752Substrate bindingUniRule annotation
Regioni184 – 1852Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVYGCTHY.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.

Sequencei

Sequence statusi: Complete.

A8YTR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRPIGLLD SGVGGFTVVK KVIEKLPHES TVFIGDSANM PYGDKSREQI
60 70 80 90 100
IELTRRSVKF LLQKKVKLII FACNTATAVA MPTLQNEVEQ QIIGVIQSGS
110 120 130 140 150
LAAARTTKNK KVAVAATPVT INSHAYQKEI KFRDPDIKVM EVAAPELAPL
160 170 180 190 200
IESQKDYDTN LAAVKRSIAP LKDQDFDTFV LGCTHYPLIQ NEFVEALGDK
210 220 230 240 250
IQIVDPADQV AQYTFNVMRR DGLFSSFDQA GKHEYYTTGD PDKFSEMGRR
260
FLGQADLTSH QVDTRNL
Length:267
Mass (Da):29,667
Last modified:January 15, 2008 - v1
Checksum:i3E685037D0F9D9F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000517 Genomic DNA. Translation: ABX26657.1.
RefSeqiWP_003627745.1. NC_010080.1.

Genome annotation databases

EnsemblBacteriaiABX26657; ABX26657; lhv_0449.
GeneIDi16795218.
KEGGilhe:lhv_0449.
PATRICi22232926. VBILacHel91643_0465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000517 Genomic DNA. Translation: ABX26657.1.
RefSeqiWP_003627745.1. NC_010080.1.

3D structure databases

ProteinModelPortaliA8YTR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405566.lhv_0449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX26657; ABX26657; lhv_0449.
GeneIDi16795218.
KEGGilhe:lhv_0449.
PATRICi22232926. VBILacHel91643_0465.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiVYGCTHY.
OrthoDBiEOG6CZQQP.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciLHEL405566:GJEN-404-MONOMER.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
    Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
    J. Bacteriol. 190:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DPC 4571.

Entry informationi

Entry nameiMURI_LACH4
AccessioniPrimary (citable) accession number: A8YTR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.