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A8YTK5 (A8YTK5_LACH4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase HAMAP MF_01511
EC=1.7.1.7 HAMAP MF_01511
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_01511
Gene names
Name:guaC HAMAP MF_01511
Ordered Locus Names:lhv_2031
OrganismLactobacillus helveticus (strain DPC 4571) [Complete proteome] [HAMAP]
Taxonomic identifier405566 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 SAAS SAAS005994

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 SAAS SAAS005994

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. HAMAP MF_01511

Ontologies

Keywords
   LigandNADP HAMAP MF_01511 SAAS SAAS005994
   Molecular functionOxidoreductase HAMAP MF_01511 SAAS SAAS005994
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding203 – 22624NADP By similarity HAMAP MF_01511

Sites

Active site1741Thioimidate intermediate By similarity HAMAP MF_01511

Sequences

Sequence LengthMass (Da)Tools
A8YTK5 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 5BAD216B889E42BA

FASTA32435,962
        10         20         30         40         50         60 
MEAFDYDNIQ LVPNKGIINS RRDADTSVKF GNRTFKIPVV PANMESVIND DLAIWLAENG 

        70         80         90        100        110        120 
YYYVMHRFQP EKRILFIKMM HEKGLFASIS VGIKDSEYKF IDELVEQNLK PEYITIDVAH 

       130        140        150        160        170        180 
GHSIYVIKMI KYIKQKLPES FLTAGNIATP EAVRELENAG ADATKVGVGP GRACITKLKT 

       190        200        210        220        230        240 
GFGTGGWQLA ALRMCSKAAS KPMIADGGIR HNGDIAKSVR FGATMVMIGS LFAGHEESPG 

       250        260        270        280        290        300 
NVIKINGKTY KQYWGSASTV QKGAYKNVEG KQMLVPYRGS IKDTLREMKE DLQSSISYAG 

       310        320 
GRDLNSIKLV DYVIVKDNIF DGDR

« Hide

References

[1]"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
J. Bacteriol. 190:727-735(2008) [PubMed: 17993529] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000517 Genomic DNA. Translation: ABX27829.1.
RefSeqYP_001578137.1. NC_010080.1.

3D structure databases

ProteinModelPortalA8YTK5.
SMRA8YTK5. Positions 4-320.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8YTK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5772133.
GenomeReviewsGene locus lhv_2031 in contig CP000517_GR.
KEGGlhe:lhv_2031.
PATRIC22236416. VBILacHel91643_2149.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8YTK5_LACH4
AccessionPrimary (citable) accession number: A8YTK5
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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