ID A8Y4W5_DROME Unreviewed; 190 AA. AC A8Y4W5; DT 15-JAN-2008, integrated into UniProtKB/TrEMBL. DT 15-JAN-2008, sequence version 1. DT 27-MAR-2024, entry version 130. DE SubName: Full=RE73195p {ECO:0000313|EMBL:ADC54216.1}; DE SubName: Full=Rolled, isoform A {ECO:0000313|EMBL:EDP28108.1}; DE EC=2.7.11.- {ECO:0000313|EMBL:EDP28108.1}; DE EC=2.7.11.24 {ECO:0000313|EMBL:EDP28108.1}; GN Name=rl {ECO:0000313|EMBL:EDP28108.1, GN ECO:0000313|FlyBase:FBgn0003256}; GN Synonyms=12559 {ECO:0000313|EMBL:EDP28108.1}, BcDNA:RE08694 GN {ECO:0000313|EMBL:EDP28108.1}, CG18732 {ECO:0000313|EMBL:EDP28108.1}, GN CT34260 {ECO:0000313|EMBL:EDP28108.1}, CT39192 GN {ECO:0000313|EMBL:EDP28108.1}, D-ERK {ECO:0000313|EMBL:EDP28108.1}, GN DERK {ECO:0000313|EMBL:EDP28108.1}, dERK GN {ECO:0000313|EMBL:EDP28108.1}, dErk {ECO:0000313|EMBL:EDP28108.1}, GN DERK-A {ECO:0000313|EMBL:EDP28108.1}, dm-dpERK GN {ECO:0000313|EMBL:EDP28108.1}, Dmel\CG12559 GN {ECO:0000313|EMBL:EDP28108.1}, DmERK {ECO:0000313|EMBL:EDP28108.1}, GN DmErk {ECO:0000313|EMBL:EDP28108.1}, DmERK-A GN {ECO:0000313|EMBL:EDP28108.1}, DmERKA {ECO:0000313|EMBL:EDP28108.1}, GN DmMAPK {ECO:0000313|EMBL:EDP28108.1}, dp-ERK GN {ECO:0000313|EMBL:EDP28108.1}, DpERK {ECO:0000313|EMBL:EDP28108.1}, GN DpErk {ECO:0000313|EMBL:EDP28108.1}, dpERK GN {ECO:0000313|EMBL:EDP28108.1}, dpERk {ECO:0000313|EMBL:EDP28108.1}, GN dpErk {ECO:0000313|EMBL:EDP28108.1}, dpERK1 GN {ECO:0000313|EMBL:EDP28108.1}, dpMAPK {ECO:0000313|EMBL:EDP28108.1}, GN Dsor2 {ECO:0000313|EMBL:EDP28108.1}, E(sina)7 GN {ECO:0000313|EMBL:EDP28108.1}, EC2-1 {ECO:0000313|EMBL:EDP28108.1}, GN EK2-1 {ECO:0000313|EMBL:EDP28108.1}, ERK GN {ECO:0000313|EMBL:EDP28108.1}, Erk {ECO:0000313|EMBL:EDP28108.1}, erk GN {ECO:0000313|EMBL:EDP28108.1}, ERK-A {ECO:0000313|EMBL:EDP28108.1}, GN Erk/Map kinase {ECO:0000313|EMBL:EDP28108.1}, Erk1 GN {ECO:0000313|EMBL:EDP28108.1}, ERK1/2 {ECO:0000313|EMBL:EDP28108.1}, GN Erk1/2 {ECO:0000313|EMBL:EDP28108.1}, ERKA GN {ECO:0000313|EMBL:EDP28108.1}, ERKa {ECO:0000313|EMBL:EDP28108.1}, GN ErkA {ECO:0000313|EMBL:EDP28108.1}, EY2-2 GN {ECO:0000313|EMBL:EDP28108.1}, GroupII {ECO:0000313|EMBL:EDP28108.1}, GN l(2)41Ac {ECO:0000313|EMBL:EDP28108.1}, l(2R)EMS45-39 GN {ECO:0000313|EMBL:EDP28108.1}, MAP-k {ECO:0000313|EMBL:EDP28108.1}, GN MAPK {ECO:0000313|EMBL:EDP28108.1}, MapK GN {ECO:0000313|EMBL:EDP28108.1}, Mapk {ECO:0000313|EMBL:EDP28108.1}, GN mapk {ECO:0000313|EMBL:EDP28108.1}, p-ERK GN {ECO:0000313|EMBL:EDP28108.1}, pERK {ECO:0000313|EMBL:EDP28108.1}, GN pMAPK {ECO:0000313|EMBL:EDP28108.1}, pMapK GN {ECO:0000313|EMBL:EDP28108.1}, RL {ECO:0000313|EMBL:EDP28108.1}, Rl GN {ECO:0000313|EMBL:EDP28108.1}, rl-RA {ECO:0000313|EMBL:ADC54216.1}, GN rl/ERK {ECO:0000313|EMBL:EDP28108.1}, rl/MAPK GN {ECO:0000313|EMBL:EDP28108.1}, rll {ECO:0000313|EMBL:EDP28108.1}, SEM GN {ECO:0000313|EMBL:EDP28108.1}, Sem {ECO:0000313|EMBL:EDP28108.1}, sem GN {ECO:0000313|EMBL:EDP28108.1}, SR2-1 {ECO:0000313|EMBL:EDP28108.1}, GN Su(Raf)2B {ECO:0000313|EMBL:EDP28108.1}; GN ORFNames=CG12559 {ECO:0000313|EMBL:EDP28108.1, GN ECO:0000313|FlyBase:FBgn0003256}, Dmel_CG12559 GN {ECO:0000313|EMBL:EDP28108.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ADC54216.1}; RN [1] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:EDP28108.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:ADC54216.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:ADC54216.1}; RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:EDP28108.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT120325; ADC54216.1; -; mRNA. DR EMBL; AE013599; EDP28108.1; -; Genomic_DNA. DR RefSeq; NP_001104350.1; NM_001110880.2. DR AlphaFoldDB; A8Y4W5; -. DR SMR; A8Y4W5; -. DR DNASU; 3354888; -. DR EnsemblMetazoa; FBtr0113701; FBpp0112424; FBgn0003256. DR GeneID; 3354888; -. DR UCSC; CG12559-RA; d. melanogaster. DR AGR; FB:FBgn0003256; -. DR CTD; 3354888; -. DR FlyBase; FBgn0003256; rl. DR VEuPathDB; VectorBase:FBgn0003256; -. DR GeneTree; ENSGT00940000156771; -. DR HOGENOM; CLU_1429393_0_0_1; -. DR OrthoDB; 158564at2759; -. DR BioGRID-ORCS; 3354888; 1 hit in 3 CRISPR screens. DR ChiTaRS; rl; fly. DR GenomeRNAi; 3354888; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0003256; Expressed in midgut and 17 other cell types or tissues. DR ExpressionAtlas; A8Y4W5; baseline and differential. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC. DR GO; GO:0033554; P:cellular response to stress; IEA:UniProt. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR PANTHER; PTHR24055; MITOGEN-ACTIVATED PROTEIN KINASE; 1. DR PANTHER; PTHR24055:SF596; MITOGEN-ACTIVATED PROTEIN KINASE ERK-A; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A8Y4W5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transferase {ECO:0000313|EMBL:EDP28108.1}. FT DOMAIN 38..190 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 68 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 190 AA; 21951 MW; 14530AA40E58BBE9 CRC64; MEEFNSSGSV VNGTGSTEVP QSNAEVIRGQ IFEVGPRYIK LAYIGEGAYG MVVSADDTLT NQRVAIKKIS PFEHQTYCQR TLREITILTR FKHENIIDIR DILRVDSIDQ MRDVYIVQCL METDLYKLLK TQVMVLPDIW LKFIERITTI DMWCIILAIT PNTKTEYNCR LSDIFNYGSD SRYAFMRALK //