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A8Y236

- GLT10_CAEBR

UniProt

A8Y236 - GLT10_CAEBR

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Protein

Putative polypeptide N-acetylgalactosaminyltransferase 10

Gene
gly-10, CBG22373
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor By similarity.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Manganese By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041Substrate By similarity
Binding sitei236 – 2361Substrate By similarity
Metal bindingi259 – 2591Manganese By similarity
Metal bindingi261 – 2611Manganese By similarity
Binding sitei362 – 3621Substrate By similarity
Metal bindingi390 – 3901Manganese By similarity
Binding sitei393 – 3931Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative polypeptide N-acetylgalactosaminyltransferase 10 (EC:2.4.1.41)
Short name:
pp-GaNTase 10
Alternative name(s):
Protein-UDP acetylgalactosaminyltransferase 10
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
Gene namesi
Name:gly-10
ORF Names:CBG22373
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG22373; CBP28929; WBGene00040946; Cbr-gly-10.

Subcellular locationi

Golgi apparatus membrane; Single-pass type II membrane protein By similarity By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei13 – 3321Helical; Signal-anchor for type II membrane proteinAdd
BLAST
Topological domaini34 – 629596Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Putative polypeptide N-acetylgalactosaminyltransferase 10PRO_0000328999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi154 ↔ 385 By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi376 ↔ 454 By similarity
Disulfide bondi493 ↔ 510 By similarity
Disulfide bondi539 ↔ 556 By similarity
Disulfide bondi582 ↔ 598 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG22373.

Structurei

3D structure databases

ProteinModelPortaliA8Y236.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini526 – 629104Ricin B-type lectinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 275113Catalytic subdomain AAdd
BLAST
Regioni331 – 39363Catalytic subdomain BAdd
BLAST
Regioni393 – 40614Flexible loop By similarityAdd
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.By similarity
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239675.
OrthoDBiEOG7J9VP2.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8Y236-1 [UniParc]FASTAAdd to Basket

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MGLSRYLSRR HHWVIQYCAL LLFLYFIYSY VAVSNDAPRL NEEIPVFREF    50
SEDLPQGSRK FPEQKPAAAL GDEALDPFEK YRGHEKIKWE DEVAYEKDKA 100
REGPGEWGKP VKLPDDKETE KEALSLYKAN GYNAYISDMI SLNRSIKDIR 150
HKECKKMTYS AKLPTVSVIF PFHEEHNSTL LRSVYSVINR SPPELLKEII 200
LVDDFSEKPA LRQPLEDFLK KNKIDHIVKI LRTKKREGLI RGRQLGAQEA 250
TGEILIFLDA HSECNYNWLP PLLDPIADDY RTVVCPFVDV IDCETYEIRP 300
QDEGARGSFD WAFNYKRLPL TKKDRENPTK PFDSPVMAGG YFAISAKWFW 350
ELGGYDEGLD IWGGEQYELS FKVWQCHGKM VDAPCSRVAH IYRCKYAPFK 400
NAGMGDFVSR NYKRVAEVWM DEYKETLYKH RPGIGNADAG DLKLMKGIRE 450
KLQCKSFDWF MKEIAFDQDK YYPAIEPKAS AEGEIRHVAS NLCIDTQFKE 500
QNQRFGLRKC ASEDKDGGGE QDLRLTRWHD IRPKGRKICF DVSTSVDKAP 550
IILFDCHSMK GNQLFKYRMP QKQIYHPVSG QCLTADENGK GFLHMKKCDS 600
SSKLQQWAWQ TIDQELLDQR QANEHKELE 629
Length:629
Mass (Da):73,008
Last modified:October 13, 2009 - v2
Checksum:iFCD8FD9F61829238
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600912 Genomic DNA. Translation: CAP38976.2.

Genome annotation databases

EnsemblMetazoaiCBG22373; CBG22373; CBG22373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600912 Genomic DNA. Translation: CAP38976.2 .

3D structure databases

ProteinModelPortali A8Y236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG22373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG22373 ; CBG22373 ; CBG22373 .

Organism-specific databases

WormBasei CBG22373 ; CBP28929 ; WBGene00040946 ; Cbr-gly-10.

Phylogenomic databases

eggNOGi NOG239675.
OrthoDBi EOG7J9VP2.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiGLT10_CAEBR
AccessioniPrimary (citable) accession number: A8Y236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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