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Protein

Inosine triphosphate pyrophosphatase

Gene

hap-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Magnesium or manganeseUniRule annotation
Binding sitei49 – 491SubstrateUniRule annotation
Metal bindingi65 – 651Magnesium or manganeseUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine triphosphate pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Short name:
ITPaseUniRule annotation
Short name:
Inosine triphosphataseUniRule annotation
Alternative name(s):
Non-canonical purine NTP pyrophosphataseUniRule annotation
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Name:hap-1UniRule annotation
ORF Names:CBG21178
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG21178; CBP05041; WBGene00040023; Cbr-hap-1.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Inosine triphosphate pyrophosphatasePRO_0000413112Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi6238.CBG21178.

Structurei

3D structure databases

ProteinModelPortaliA8XZP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 156Substrate bindingUniRule annotation
Regioni65 – 662Substrate bindingUniRule annotation
Regioni141 – 1444Substrate bindingUniRule annotation
Regioni169 – 1702Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3222. Eukaryota.
COG0127. LUCA.
HOGENOMiHOG000293320.
InParanoidiA8XZP2.
KOiK01519.
OMAiMKIYFAT.
OrthoDBiEOG091G0MUD.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_03148. HAM1_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

A8XZP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRKINFVT GNAKKLQEVK EILKGFEVTN VDVDLNEYQG EPEFIAQKKC
60 70 80 90 100
QEAVEAVKGP VLVEDTSLCF NAMGGLPGPY IKWFLTNLKP DGLYNMLTGF
110 120 130 140 150
ADKTAYAQCI FAYTEGLGKP IHVFAGKCPG QIVAPRGDTS FGWDPCFQPD
160 170 180
GFEETFGEMD KDVKNEISHR SKALDLLKEY FEKN
Length:184
Mass (Da):20,575
Last modified:January 15, 2008 - v1
Checksum:i71B65A01F5FFD5DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600921 Genomic DNA. Translation: CAP38041.1.
RefSeqiXP_002642784.1. XM_002642738.1.

Genome annotation databases

EnsemblMetazoaiCBG21178; CBG21178; WBGene00040023.
GeneIDi8584778.
KEGGicbr:CBG21178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600921 Genomic DNA. Translation: CAP38041.1.
RefSeqiXP_002642784.1. XM_002642738.1.

3D structure databases

ProteinModelPortaliA8XZP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG21178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG21178; CBG21178; WBGene00040023.
GeneIDi8584778.
KEGGicbr:CBG21178.

Organism-specific databases

CTDi8584778.
WormBaseiCBG21178; CBP05041; WBGene00040023; Cbr-hap-1.

Phylogenomic databases

eggNOGiKOG3222. Eukaryota.
COG0127. LUCA.
HOGENOMiHOG000293320.
InParanoidiA8XZP2.
KOiK01519.
OMAiMKIYFAT.
OrthoDBiEOG091G0MUD.

Family and domain databases

CDDicd00515. HAM1. 1 hit.
Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_03148. HAM1_NTPase. 1 hit.
InterProiIPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiITPA_CAEBR
AccessioniPrimary (citable) accession number: A8XZP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2011
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.