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Protein

Chondroitin proteoglycan 2

Gene

cpg-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Chitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin proteoglycan 2
Gene namesi
Name:cpg-2
ORF Names:CBG20011
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome IV, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG20011; CBP27389; WBGene00039115; Cbr-cpg-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000032022019 – 491Chondroitin proteoglycan 2Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
Disulfide bondi158 ↔ 171PROSITE-ProRule annotation
Glycosylationi197O-linked (Xyl...) (chondroitin sulfate)By similarity1
Glycosylationi201O-linked (Xyl...) (chondroitin sulfate)By similarity1
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation
Disulfide bondi310 ↔ 323PROSITE-ProRule annotation
Disulfide bondi399 ↔ 412PROSITE-ProRule annotation
Glycosylationi464N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi467 ↔ 481PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG20011.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 78Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST58
Domaini125 – 182Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST58
Domaini217 – 274Chitin-binding type-2 3PROSITE-ProRule annotationAdd BLAST58
Domaini279 – 334Chitin-binding type-2 4PROSITE-ProRule annotationAdd BLAST56
Domaini367 – 423Chitin-binding type-2 5PROSITE-ProRule annotationAdd BLAST57
Domaini436 – 491Chitin-binding type-2 6PROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 6 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ6B. Eukaryota.
ENOG4111EXD. LUCA.
HOGENOMiHOG000017714.
InParanoidiA8XWX5.
OMAiFDCSTDG.
OrthoDBiEOG091G0LTG.

Family and domain databases

Gene3Di2.170.140.10. 6 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 6 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 6 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 6 hits.
PROSITEiPS50940. CHIT_BIND_II. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XWX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIVALGLL ALATAASGQF LQDCTNALDG LYAIGNCESQ FLTCSGGIAR
60 70 80 90 100
IMDCPADLIY NEPLLICDWR HNVVGCEGSG EASGEQSGEG SGEASGEGSG
110 120 130 140 150
EASGEGSGEA SGEGSGSGEG SGEENNVCEG LEDGAYSSGG CTTYYFFCTD
160 170 180 190 200
NTARFLSCPT PLFYDVATQK CAWKALVEEC NGEIIIDGSG ETSGEGSGEA
210 220 230 240 250
SGENSGENSG EGSGEFEPTC DGKADGIYPN GVCVPNFLTC SGGIARVMNC
260 270 280 290 300
PASLIFNPDI LVCDWPRDVA ECHGLSTPAP VCEDDGYFSF GQCSSSFTAC
310 320 330 340 350
TNGRAIVMFC PAGLKFSQAN QRCDYDDLVN ECQEASGEES SGEASGEQSG
360 370 380 390 400
EGSGEASGEA SGEASGENEC VSLDNGLHAI GCSPRVLSCQ NGHVDIFECP
410 420 430 440 450
SSLVFNEQTL ICDYPQTSLK CLIEDTLLID ETPITPFDCS TNGLFSDGLC
460 470 480 490
SATYHQCSAG QLINFTCAET NAVFSAANAE CVDSSTLLQC H
Length:491
Mass (Da):50,710
Last modified:September 22, 2009 - v2
Checksum:i70D20DFA6869A87C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601481 Genomic DNA. Translation: CAP37144.2.

Genome annotation databases

EnsemblMetazoaiCBG20011; CBG20011; WBGene00039115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601481 Genomic DNA. Translation: CAP37144.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG20011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG20011; CBG20011; WBGene00039115.

Organism-specific databases

WormBaseiCBG20011; CBP27389; WBGene00039115; Cbr-cpg-2.

Phylogenomic databases

eggNOGiENOG410IJ6B. Eukaryota.
ENOG4111EXD. LUCA.
HOGENOMiHOG000017714.
InParanoidiA8XWX5.
OMAiFDCSTDG.
OrthoDBiEOG091G0LTG.

Family and domain databases

Gene3Di2.170.140.10. 6 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 6 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 6 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 6 hits.
PROSITEiPS50940. CHIT_BIND_II. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPG2_CAEBR
AccessioniPrimary (citable) accession number: A8XWX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 22, 2009
Last modified: November 30, 2016
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.