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A8XWX5

- CPG2_CAEBR

UniProt

A8XWX5 - CPG2_CAEBR

Protein

Chondroitin proteoglycan 2

Gene

cpg-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin By similarity.By similarity

    GO - Molecular functioni

    1. chitin binding Source: UniProtKB

    GO - Biological processi

    1. chitin metabolic process Source: InterPro
    2. embryo development Source: UniProtKB
    3. mitotic cytokinesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    Chitin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chondroitin proteoglycan 2
    Gene namesi
    Name:cpg-2
    ORF Names:CBG20011
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG20011; CBP27389; WBGene00039115; Cbr-cpg-2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 491473Chondroitin proteoglycan 2PRO_0000320220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
    Disulfide bondi158 ↔ 171PROSITE-ProRule annotation
    Glycosylationi197 – 1971O-linked (Xyl...) (chondroitin sulfate)By similarity
    Glycosylationi201 – 2011O-linked (Xyl...) (chondroitin sulfate)By similarity
    Disulfide bondi250 ↔ 263PROSITE-ProRule annotation
    Disulfide bondi310 ↔ 323PROSITE-ProRule annotation
    Disulfide bondi399 ↔ 412PROSITE-ProRule annotation
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi467 ↔ 481PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG20011.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 7858Chitin-binding type-2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini125 – 18258Chitin-binding type-2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini217 – 27458Chitin-binding type-2 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 33456Chitin-binding type-2 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini367 – 42357Chitin-binding type-2 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini436 – 49156Chitin-binding type-2 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 chitin-binding type-2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG241358.
    HOGENOMiHOG000017714.
    OrthoDBiEOG7JT6WN.

    Family and domain databases

    Gene3Di2.170.140.10. 5 hits.
    InterProiIPR002557. Chitin-bd_dom.
    [Graphical view]
    PfamiPF01607. CBM_14. 6 hits.
    [Graphical view]
    SMARTiSM00494. ChtBD2. 6 hits.
    [Graphical view]
    SUPFAMiSSF57625. SSF57625. 6 hits.
    PROSITEiPS50940. CHIT_BIND_II. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8XWX5-1 [UniParc]FASTAAdd to Basket

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    MKTIVALGLL ALATAASGQF LQDCTNALDG LYAIGNCESQ FLTCSGGIAR    50
    IMDCPADLIY NEPLLICDWR HNVVGCEGSG EASGEQSGEG SGEASGEGSG 100
    EASGEGSGEA SGEGSGSGEG SGEENNVCEG LEDGAYSSGG CTTYYFFCTD 150
    NTARFLSCPT PLFYDVATQK CAWKALVEEC NGEIIIDGSG ETSGEGSGEA 200
    SGENSGENSG EGSGEFEPTC DGKADGIYPN GVCVPNFLTC SGGIARVMNC 250
    PASLIFNPDI LVCDWPRDVA ECHGLSTPAP VCEDDGYFSF GQCSSSFTAC 300
    TNGRAIVMFC PAGLKFSQAN QRCDYDDLVN ECQEASGEES SGEASGEQSG 350
    EGSGEASGEA SGEASGENEC VSLDNGLHAI GCSPRVLSCQ NGHVDIFECP 400
    SSLVFNEQTL ICDYPQTSLK CLIEDTLLID ETPITPFDCS TNGLFSDGLC 450
    SATYHQCSAG QLINFTCAET NAVFSAANAE CVDSSTLLQC H 491
    Length:491
    Mass (Da):50,710
    Last modified:September 22, 2009 - v2
    Checksum:i70D20DFA6869A87C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601481 Genomic DNA. Translation: CAP37144.2.

    Genome annotation databases

    EnsemblMetazoaiCBG20011; CBG20011; CBG20011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601481 Genomic DNA. Translation: CAP37144.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG20011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG20011 ; CBG20011 ; CBG20011 .

    Organism-specific databases

    WormBasei CBG20011 ; CBP27389 ; WBGene00039115 ; Cbr-cpg-2.

    Phylogenomic databases

    eggNOGi NOG241358.
    HOGENOMi HOG000017714.
    OrthoDBi EOG7JT6WN.

    Family and domain databases

    Gene3Di 2.170.140.10. 5 hits.
    InterProi IPR002557. Chitin-bd_dom.
    [Graphical view ]
    Pfami PF01607. CBM_14. 6 hits.
    [Graphical view ]
    SMARTi SM00494. ChtBD2. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57625. SSF57625. 6 hits.
    PROSITEi PS50940. CHIT_BIND_II. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiCPG2_CAEBR
    AccessioniPrimary (citable) accession number: A8XWX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3