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Protein

Chondroitin proteoglycan 2

Gene

cpg-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division
LigandChitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin proteoglycan 2
Gene namesi
Name:cpg-2
ORF Names:CBG20011
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome IV, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG20011 ; CBP27389 ; WBGene00039115 ; Cbr-cpg-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000032022019 – 491Chondroitin proteoglycan 2Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
Disulfide bondi158 ↔ 171PROSITE-ProRule annotation
Glycosylationi197O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi201O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation
Disulfide bondi310 ↔ 323PROSITE-ProRule annotation
Disulfide bondi399 ↔ 412PROSITE-ProRule annotation
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi467 ↔ 481PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG20011

Structurei

3D structure databases

SMRiA8XWX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 78Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST58
Domaini125 – 182Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST58
Domaini217 – 274Chitin-binding type-2 3PROSITE-ProRule annotationAdd BLAST58
Domaini279 – 334Chitin-binding type-2 4PROSITE-ProRule annotationAdd BLAST56
Domaini367 – 423Chitin-binding type-2 5PROSITE-ProRule annotationAdd BLAST57
Domaini436 – 491Chitin-binding type-2 6PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IJ6B Eukaryota
ENOG4111EXD LUCA
HOGENOMiHOG000017714
InParanoidiA8XWX5
OMAiCTCDCCA
OrthoDBiEOG091G0LTG

Family and domain databases

InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
PfamiView protein in Pfam
PF01607 CBM_14, 6 hits
SMARTiView protein in SMART
SM00494 ChtBD2, 6 hits
SUPFAMiSSF57625 SSF57625, 6 hits
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XWX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIVALGLL ALATAASGQF LQDCTNALDG LYAIGNCESQ FLTCSGGIAR
60 70 80 90 100
IMDCPADLIY NEPLLICDWR HNVVGCEGSG EASGEQSGEG SGEASGEGSG
110 120 130 140 150
EASGEGSGEA SGEGSGSGEG SGEENNVCEG LEDGAYSSGG CTTYYFFCTD
160 170 180 190 200
NTARFLSCPT PLFYDVATQK CAWKALVEEC NGEIIIDGSG ETSGEGSGEA
210 220 230 240 250
SGENSGENSG EGSGEFEPTC DGKADGIYPN GVCVPNFLTC SGGIARVMNC
260 270 280 290 300
PASLIFNPDI LVCDWPRDVA ECHGLSTPAP VCEDDGYFSF GQCSSSFTAC
310 320 330 340 350
TNGRAIVMFC PAGLKFSQAN QRCDYDDLVN ECQEASGEES SGEASGEQSG
360 370 380 390 400
EGSGEASGEA SGEASGENEC VSLDNGLHAI GCSPRVLSCQ NGHVDIFECP
410 420 430 440 450
SSLVFNEQTL ICDYPQTSLK CLIEDTLLID ETPITPFDCS TNGLFSDGLC
460 470 480 490
SATYHQCSAG QLINFTCAET NAVFSAANAE CVDSSTLLQC H
Length:491
Mass (Da):50,710
Last modified:September 22, 2009 - v2
Checksum:i70D20DFA6869A87C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601481 Genomic DNA Translation: CAP37144.2

Genome annotation databases

EnsemblMetazoaiCBG20011; CBG20011; WBGene00039115

Similar proteinsi

Entry informationi

Entry nameiCPG2_CAEBR
AccessioniPrimary (citable) accession number: A8XWX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health