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A8XWX5

- CPG2_CAEBR

UniProt

A8XWX5 - CPG2_CAEBR

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Protein

Chondroitin proteoglycan 2

Gene

cpg-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin (By similarity).By similarity

GO - Molecular functioni

  1. chitin binding Source: UniProtKB

GO - Biological processi

  1. chitin metabolic process Source: InterPro
  2. embryo development Source: UniProtKB
  3. mitotic cytokinesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Chitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin proteoglycan 2
Gene namesi
Name:cpg-2
ORF Names:CBG20011
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG20011; CBP27389; WBGene00039115; Cbr-cpg-2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 491473Chondroitin proteoglycan 2PRO_0000320220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
Disulfide bondi158 ↔ 171PROSITE-ProRule annotation
Glycosylationi197 – 1971O-linked (Xyl...) (chondroitin sulfate)By similarity
Glycosylationi201 – 2011O-linked (Xyl...) (chondroitin sulfate)By similarity
Disulfide bondi250 ↔ 263PROSITE-ProRule annotation
Disulfide bondi310 ↔ 323PROSITE-ProRule annotation
Disulfide bondi399 ↔ 412PROSITE-ProRule annotation
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi467 ↔ 481PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG20011.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 7858Chitin-binding type-2 1PROSITE-ProRule annotationAdd
BLAST
Domaini125 – 18258Chitin-binding type-2 2PROSITE-ProRule annotationAdd
BLAST
Domaini217 – 27458Chitin-binding type-2 3PROSITE-ProRule annotationAdd
BLAST
Domaini279 – 33456Chitin-binding type-2 4PROSITE-ProRule annotationAdd
BLAST
Domaini367 – 42357Chitin-binding type-2 5PROSITE-ProRule annotationAdd
BLAST
Domaini436 – 49156Chitin-binding type-2 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG241358.
HOGENOMiHOG000017714.
InParanoidiA8XWX5.
OrthoDBiEOG7JT6WN.

Family and domain databases

Gene3Di2.170.140.10. 5 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 6 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 6 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 6 hits.
PROSITEiPS50940. CHIT_BIND_II. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XWX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTIVALGLL ALATAASGQF LQDCTNALDG LYAIGNCESQ FLTCSGGIAR
60 70 80 90 100
IMDCPADLIY NEPLLICDWR HNVVGCEGSG EASGEQSGEG SGEASGEGSG
110 120 130 140 150
EASGEGSGEA SGEGSGSGEG SGEENNVCEG LEDGAYSSGG CTTYYFFCTD
160 170 180 190 200
NTARFLSCPT PLFYDVATQK CAWKALVEEC NGEIIIDGSG ETSGEGSGEA
210 220 230 240 250
SGENSGENSG EGSGEFEPTC DGKADGIYPN GVCVPNFLTC SGGIARVMNC
260 270 280 290 300
PASLIFNPDI LVCDWPRDVA ECHGLSTPAP VCEDDGYFSF GQCSSSFTAC
310 320 330 340 350
TNGRAIVMFC PAGLKFSQAN QRCDYDDLVN ECQEASGEES SGEASGEQSG
360 370 380 390 400
EGSGEASGEA SGEASGENEC VSLDNGLHAI GCSPRVLSCQ NGHVDIFECP
410 420 430 440 450
SSLVFNEQTL ICDYPQTSLK CLIEDTLLID ETPITPFDCS TNGLFSDGLC
460 470 480 490
SATYHQCSAG QLINFTCAET NAVFSAANAE CVDSSTLLQC H
Length:491
Mass (Da):50,710
Last modified:September 22, 2009 - v2
Checksum:i70D20DFA6869A87C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601481 Genomic DNA. Translation: CAP37144.2.

Genome annotation databases

EnsemblMetazoaiCBG20011; CBG20011; CBG20011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601481 Genomic DNA. Translation: CAP37144.2 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG20011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG20011 ; CBG20011 ; CBG20011 .

Organism-specific databases

WormBasei CBG20011 ; CBP27389 ; WBGene00039115 ; Cbr-cpg-2.

Phylogenomic databases

eggNOGi NOG241358.
HOGENOMi HOG000017714.
InParanoidi A8XWX5.
OrthoDBi EOG7JT6WN.

Family and domain databases

Gene3Di 2.170.140.10. 5 hits.
InterProi IPR002557. Chitin-bd_dom.
[Graphical view ]
Pfami PF01607. CBM_14. 6 hits.
[Graphical view ]
SMARTi SM00494. ChtBD2. 6 hits.
[Graphical view ]
SUPFAMi SSF57625. SSF57625. 6 hits.
PROSITEi PS50940. CHIT_BIND_II. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiCPG2_CAEBR
AccessioniPrimary (citable) accession number: A8XWX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3