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A8XT88 (FBSP1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene names
Name:fsn-1
ORF Names:CBG18196
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. May stabilize synapse formation by promoting the down-regulation of scd-2 By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 By similarity.

Subcellular location

Cell junctionsynapse By similarity.

Sequence similarities

Belongs to the FBXO45/Fsn family.

Contains 1 B30.2/SPRY domain.

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCell junction
Synapse
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332F-box/SPRY domain-containing protein 1
PRO_0000383748

Regions

Domain79 – 12749F-box
Domain138 – 330193B30.2/SPRY

Sequences

Sequence LengthMass (Da)Tools
A8XT88 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 11E67CA7CA71259F

FASTA33237,225
        10         20         30         40         50         60 
MTENNEETIV PDEQCNLTSS TPMKSSDLEN VESPIERKIS IVECDGEGNP PIESSEETPP 

        70         80         90        100        110        120 
DLTSHSVAPR RRRSPRRPEV SASRLPLKVL NQIFQYLSLK DLRSAMLTCH SWNNALSMED 

       130        140        150        160        170        180 
SDIWQQLLVQ KLPEAAHSDP FLFVELRSAR KKLRAWYFAW NTNDISRNNY IRTNGFTVHR 

       190        200        210        220        230        240 
QPVAQSTDGV RGKRGVSQGV HAFDITWDGP LGTVAVVGFA TKHAALHCVG YIALLGSDDQ 

       250        260        270        280        290        300 
SWGWNLVDNV LMHNGVQLGV YPKMNNPPKY EVGEKIRLVI DCDMHVAYFE RNSEFLGIAF 

       310        320        330 
SHIPPLRLFP AVCAVYGNTE VTMVYVGSPQ MG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600936 Genomic DNA. Translation: CAP35691.1.
RefSeqXP_002642222.1. XM_002642176.1.

3D structure databases

ProteinModelPortalA8XT88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG18196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG18196; CBG18196; CBG18196.
GeneID8584218.
KEGGcbr:CBG18196.

Organism-specific databases

CTD8584218.
WormBaseCBG18196; CBP04261; WBGene00037661; Cbr-fsn-1.

Phylogenomic databases

eggNOGNOG263387.
HOGENOMHOG000230524.
KOK10319.
OMADNVLMHN.
OrthoDBEOG7QZGBV.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

InterProIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamPF00646. F-box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFBSP1_CAEBR
AccessionPrimary (citable) accession number: A8XT88
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: November 13, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways