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Protein

F-box/SPRY domain-containing protein 1

Gene

fsn-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
Name:fsn-1
ORF Names:CBG18196
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome III, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG18196 ; CBP04261 ; WBGene00037661 ; Cbr-fsn-1

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003837481 – 332F-box/SPRY domain-containing protein 1Add BLAST332

Interactioni

Subunit structurei

Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1. Interacts (via SPRY domain) with scd-2 (via cytoplasmic domain). Interacts (via SPRY domain) with convertase egl-3 (via C-terminus).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6238.CBG18196

Structurei

3D structure databases

ProteinModelPortaliA8XT88
SMRiA8XT88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 127F-boxPROSITE-ProRule annotationAdd BLAST49
Domaini138 – 330B30.2/SPRYPROSITE-ProRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated

Phylogenomic databases

eggNOGiKOG3953 Eukaryota
ENOG410XQC1 LUCA
HOGENOMiHOG000230524
InParanoidiA8XT88
KOiK10319
OMAiEIWWEGP
OrthoDBiEOG091G0DF0

Family and domain databases

CDDicd12907 SPRY_Fbox, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR003877 SPRY_dom
IPR035784 SPRY_FBXO45
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

A8XT88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENNEETIV PDEQCNLTSS TPMKSSDLEN VESPIERKIS IVECDGEGNP
60 70 80 90 100
PIESSEETPP DLTSHSVAPR RRRSPRRPEV SASRLPLKVL NQIFQYLSLK
110 120 130 140 150
DLRSAMLTCH SWNNALSMED SDIWQQLLVQ KLPEAAHSDP FLFVELRSAR
160 170 180 190 200
KKLRAWYFAW NTNDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGVSQGV
210 220 230 240 250
HAFDITWDGP LGTVAVVGFA TKHAALHCVG YIALLGSDDQ SWGWNLVDNV
260 270 280 290 300
LMHNGVQLGV YPKMNNPPKY EVGEKIRLVI DCDMHVAYFE RNSEFLGIAF
310 320 330
SHIPPLRLFP AVCAVYGNTE VTMVYVGSPQ MG
Length:332
Mass (Da):37,225
Last modified:January 15, 2008 - v1
Checksum:i11E67CA7CA71259F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600936 Genomic DNA Translation: CAP35691.1
RefSeqiXP_002642222.1, XM_002642176.1

Genome annotation databases

EnsemblMetazoaiCBG18196.1; CBG18196.1; WBGene00037661
CBG18196.2; CBG18196.2; WBGene00037661
GeneIDi8584218
KEGGicbr:CBG18196

Similar proteinsi

Entry informationi

Entry nameiFBSP1_CAEBR
AccessioniPrimary (citable) accession number: A8XT88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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