Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A8XT88

- FBSP1_CAEBR

UniProt

A8XT88 - FBSP1_CAEBR

Protein

F-box/SPRY domain-containing protein 1

Gene

fsn-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. May stabilize synapse formation by promoting the down-regulation of scd-2 By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/SPRY domain-containing protein 1
    Alternative name(s):
    F-box synaptic protein 1
    Gene namesi
    Name:fsn-1
    ORF Names:CBG18196
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG18196; CBP04261; WBGene00037661; Cbr-fsn-1.

    Subcellular locationi

    Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332F-box/SPRY domain-containing protein 1PRO_0000383748Add
    BLAST

    Interactioni

    Subunit structurei

    Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG18196.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XT88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 12749F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 330193B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FBXO45/Fsn family.Curated
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG263387.
    HOGENOMiHOG000230524.
    KOiK10319.
    OMAiDNVLMHN.
    OrthoDBiEOG7QZGBV.

    Family and domain databases

    InterProiIPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XT88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENNEETIV PDEQCNLTSS TPMKSSDLEN VESPIERKIS IVECDGEGNP    50
    PIESSEETPP DLTSHSVAPR RRRSPRRPEV SASRLPLKVL NQIFQYLSLK 100
    DLRSAMLTCH SWNNALSMED SDIWQQLLVQ KLPEAAHSDP FLFVELRSAR 150
    KKLRAWYFAW NTNDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGVSQGV 200
    HAFDITWDGP LGTVAVVGFA TKHAALHCVG YIALLGSDDQ SWGWNLVDNV 250
    LMHNGVQLGV YPKMNNPPKY EVGEKIRLVI DCDMHVAYFE RNSEFLGIAF 300
    SHIPPLRLFP AVCAVYGNTE VTMVYVGSPQ MG 332
    Length:332
    Mass (Da):37,225
    Last modified:January 15, 2008 - v1
    Checksum:i11E67CA7CA71259F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600936 Genomic DNA. Translation: CAP35691.1.
    RefSeqiXP_002642222.1. XM_002642176.1.

    Genome annotation databases

    EnsemblMetazoaiCBG18196; CBG18196; CBG18196.
    GeneIDi8584218.
    KEGGicbr:CBG18196.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600936 Genomic DNA. Translation: CAP35691.1 .
    RefSeqi XP_002642222.1. XM_002642176.1.

    3D structure databases

    ProteinModelPortali A8XT88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG18196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG18196 ; CBG18196 ; CBG18196 .
    GeneIDi 8584218.
    KEGGi cbr:CBG18196.

    Organism-specific databases

    CTDi 8584218.
    WormBasei CBG18196 ; CBP04261 ; WBGene00037661 ; Cbr-fsn-1.

    Phylogenomic databases

    eggNOGi NOG263387.
    HOGENOMi HOG000230524.
    KOi K10319.
    OMAi DNVLMHN.
    OrthoDBi EOG7QZGBV.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    InterProi IPR001870. B30.2/SPRY.
    IPR008985. ConA-like_lec_gl_sf.
    IPR001810. F-box_dom.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiFBSP1_CAEBR
    AccessioniPrimary (citable) accession number: A8XT88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3