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A8XT88

- FBSP1_CAEBR

UniProt

A8XT88 - FBSP1_CAEBR

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Protein
F-box/SPRY domain-containing protein 1
Gene
fsn-1, CBG18196
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. May stabilize synapse formation by promoting the down-regulation of scd-2 By similarity.

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
Name:fsn-1
ORF Names:CBG18196
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG18196; CBP04261; WBGene00037661; Cbr-fsn-1.

Subcellular locationi

Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332F-box/SPRY domain-containing protein 1
PRO_0000383748Add
BLAST

Interactioni

Subunit structurei

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 By similarity.

Protein-protein interaction databases

STRINGi6238.CBG18196.

Structurei

3D structure databases

ProteinModelPortaliA8XT88.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 12749F-box
Add
BLAST
Domaini138 – 330193B30.2/SPRY
Add
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.
Contains 1 B30.2/SPRY domain.
Contains 1 F-box domain.

Phylogenomic databases

eggNOGiNOG263387.
HOGENOMiHOG000230524.
KOiK10319.
OMAiDNVLMHN.
OrthoDBiEOG7QZGBV.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XT88-1 [UniParc]FASTAAdd to Basket

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MTENNEETIV PDEQCNLTSS TPMKSSDLEN VESPIERKIS IVECDGEGNP    50
PIESSEETPP DLTSHSVAPR RRRSPRRPEV SASRLPLKVL NQIFQYLSLK 100
DLRSAMLTCH SWNNALSMED SDIWQQLLVQ KLPEAAHSDP FLFVELRSAR 150
KKLRAWYFAW NTNDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGVSQGV 200
HAFDITWDGP LGTVAVVGFA TKHAALHCVG YIALLGSDDQ SWGWNLVDNV 250
LMHNGVQLGV YPKMNNPPKY EVGEKIRLVI DCDMHVAYFE RNSEFLGIAF 300
SHIPPLRLFP AVCAVYGNTE VTMVYVGSPQ MG 332
Length:332
Mass (Da):37,225
Last modified:January 15, 2008 - v1
Checksum:i11E67CA7CA71259F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600936 Genomic DNA. Translation: CAP35691.1.
RefSeqiXP_002642222.1. XM_002642176.1.

Genome annotation databases

EnsemblMetazoaiCBG18196; CBG18196; CBG18196.
GeneIDi8584218.
KEGGicbr:CBG18196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600936 Genomic DNA. Translation: CAP35691.1 .
RefSeqi XP_002642222.1. XM_002642176.1.

3D structure databases

ProteinModelPortali A8XT88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG18196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG18196 ; CBG18196 ; CBG18196 .
GeneIDi 8584218.
KEGGi cbr:CBG18196.

Organism-specific databases

CTDi 8584218.
WormBasei CBG18196 ; CBP04261 ; WBGene00037661 ; Cbr-fsn-1.

Phylogenomic databases

eggNOGi NOG263387.
HOGENOMi HOG000230524.
KOi K10319.
OMAi DNVLMHN.
OrthoDBi EOG7QZGBV.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001870. B30.2/SPRY.
IPR008985. ConA-like_lec_gl_sf.
IPR001810. F-box_dom.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiFBSP1_CAEBR
AccessioniPrimary (citable) accession number: A8XT88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: November 13, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi