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A8XT88

- FBSP1_CAEBR

UniProt

A8XT88 - FBSP1_CAEBR

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Protein

F-box/SPRY domain-containing protein 1

Gene

fsn-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. May stabilize synapse formation by promoting the down-regulation of scd-2 (By similarity).By similarity

Pathwayi

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/SPRY domain-containing protein 1
Alternative name(s):
F-box synaptic protein 1
Gene namesi
Name:fsn-1
ORF Names:CBG18196
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG18196; CBP04261; WBGene00037661; Cbr-fsn-1.

Subcellular locationi

Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332F-box/SPRY domain-containing protein 1PRO_0000383748Add
BLAST

Interactioni

Subunit structurei

Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1.By similarity

Protein-protein interaction databases

STRINGi6238.CBG18196.

Structurei

3D structure databases

ProteinModelPortaliA8XT88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 12749F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini138 – 330193B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO45/Fsn family.Curated
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG263387.
HOGENOMiHOG000230524.
InParanoidiA8XT88.
KOiK10319.
OMAiDNVLMHN.
OrthoDBiEOG7QZGBV.

Family and domain databases

InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XT88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTENNEETIV PDEQCNLTSS TPMKSSDLEN VESPIERKIS IVECDGEGNP
60 70 80 90 100
PIESSEETPP DLTSHSVAPR RRRSPRRPEV SASRLPLKVL NQIFQYLSLK
110 120 130 140 150
DLRSAMLTCH SWNNALSMED SDIWQQLLVQ KLPEAAHSDP FLFVELRSAR
160 170 180 190 200
KKLRAWYFAW NTNDISRNNY IRTNGFTVHR QPVAQSTDGV RGKRGVSQGV
210 220 230 240 250
HAFDITWDGP LGTVAVVGFA TKHAALHCVG YIALLGSDDQ SWGWNLVDNV
260 270 280 290 300
LMHNGVQLGV YPKMNNPPKY EVGEKIRLVI DCDMHVAYFE RNSEFLGIAF
310 320 330
SHIPPLRLFP AVCAVYGNTE VTMVYVGSPQ MG
Length:332
Mass (Da):37,225
Last modified:January 15, 2008 - v1
Checksum:i11E67CA7CA71259F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600936 Genomic DNA. Translation: CAP35691.1.
RefSeqiXP_002642222.1. XM_002642176.1.

Genome annotation databases

EnsemblMetazoaiCBG18196; CBG18196; CBG18196.
GeneIDi8584218.
KEGGicbr:CBG18196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600936 Genomic DNA. Translation: CAP35691.1 .
RefSeqi XP_002642222.1. XM_002642176.1.

3D structure databases

ProteinModelPortali A8XT88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG18196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG18196 ; CBG18196 ; CBG18196 .
GeneIDi 8584218.
KEGGi cbr:CBG18196.

Organism-specific databases

CTDi 8584218.
WormBasei CBG18196 ; CBP04261 ; WBGene00037661 ; Cbr-fsn-1.

Phylogenomic databases

eggNOGi NOG263387.
HOGENOMi HOG000230524.
InParanoidi A8XT88.
KOi K10319.
OMAi DNVLMHN.
OrthoDBi EOG7QZGBV.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

InterProi IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR001810. F-box_dom.
IPR003877. SPRY_dom.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiFBSP1_CAEBR
AccessioniPrimary (citable) accession number: A8XT88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3