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A8XT16 (GSTO2_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glutathione transferase omega-2

EC=2.5.1.18
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase
EC=1.8.5.1
Monomethylarsonic acid reductase
Short name=MMA(V) reductase
EC=1.20.4.2
Gene names
Name:gsto-2
ORF Names:CBG18105
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sequence similarities

Belongs to the GST superfamily. Omega family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Probable glutathione transferase omega-2
PRO_0000352791

Regions

Domain25 – 10581GST N-terminal
Domain110 – 238129GST C-terminal
Region89 – 902Glutathione binding By similarity

Sites

Active site351Nucleophile By similarity
Binding site621Glutathione By similarity
Binding site751Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A8XT16 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 51F08F8D028C57A5

FASTA25328,451
        10         20         30         40         50         60 
MPVLAGINSK VLKNGDSEPS PPPAGIYRIY NMRFCPWAQR ALIYASVKNV PSEVINIHLK 

        70         80         90        100        110        120 
EKPDWYFSKH YKGQVPALEL DEGKKHVIES AHIPEYLDDL FPESRILPSD PYEKVQQKLL 

       130        140        150        160        170        180 
LERLAAVAPA FYAAAQAANN PEGRDEKYAA LVKAFEDAEK LLTGDFFSGK AKPGFADYLI 

       190        200        210        220        230        240 
FPNYQRVFWL SHILPNSPFS SESFPGPNFP KLAKWYRTLD SIPEVAAASQ PTEMGVGFFN 

       250 
DYLKGTPNYD YGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600963 Genomic DNA. Translation: CAP35619.1.
RefSeqXP_002642151.1. XM_002642105.1.

3D structure databases

ProteinModelPortalA8XT16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG18105.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG18105; CBG18105; CBG18105.
GeneID8584146.
KEGGcbr:CBG18105.

Organism-specific databases

CTD8584146.
WormBaseCBG18105; CBP10756; WBGene00037589; Cbr-gsto-2.

Phylogenomic databases

eggNOGNOG288793.
HOGENOMHOG000006560.
KOK00799.
OMAHHSVYIN.
OrthoDBEOG71CFNG.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSPR01625. GSTRNSFRASEO.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTO2_CAEBR
AccessionPrimary (citable) accession number: A8XT16
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families