SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8XT16

- GSTO2_CAEBR

UniProt

A8XT16 - GSTO2_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable glutathione transferase omega-2
Gene
gsto-2, CBG18105
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Nucleophile By similarity
Binding sitei62 – 621Glutathione By similarity
Binding sitei75 – 751Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione transferase omega-2 (EC:2.5.1.18)
    Alternative name(s):
    Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
    Monomethylarsonic acid reductase (EC:1.20.4.2)
    Short name:
    MMA(V) reductase
    Gene namesi
    Name:gsto-2
    ORF Names:CBG18105
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG18105; CBP10756; WBGene00037589; Cbr-gsto-2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253Probable glutathione transferase omega-2
    PRO_0000352791Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG18105.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XT16.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 10581GST N-terminal
    Add
    BLAST
    Domaini110 – 238129GST C-terminal
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 902Glutathione binding By similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Omega family.

    Phylogenomic databases

    eggNOGiNOG288793.
    HOGENOMiHOG000006560.
    KOiK00799.
    OMAiHHSVYIN.
    OrthoDBiEOG71CFNG.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13417. GST_N_3. 1 hit.
    [Graphical view]
    PRINTSiPR01625. GSTRNSFRASEO.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XT16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVLAGINSK VLKNGDSEPS PPPAGIYRIY NMRFCPWAQR ALIYASVKNV    50
    PSEVINIHLK EKPDWYFSKH YKGQVPALEL DEGKKHVIES AHIPEYLDDL 100
    FPESRILPSD PYEKVQQKLL LERLAAVAPA FYAAAQAANN PEGRDEKYAA 150
    LVKAFEDAEK LLTGDFFSGK AKPGFADYLI FPNYQRVFWL SHILPNSPFS 200
    SESFPGPNFP KLAKWYRTLD SIPEVAAASQ PTEMGVGFFN DYLKGTPNYD 250
    YGL 253
    Length:253
    Mass (Da):28,451
    Last modified:January 15, 2008 - v1
    Checksum:i51F08F8D028C57A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600963 Genomic DNA. Translation: CAP35619.1.
    RefSeqiXP_002642151.1. XM_002642105.1.

    Genome annotation databases

    EnsemblMetazoaiCBG18105; CBG18105; CBG18105.
    GeneIDi8584146.
    KEGGicbr:CBG18105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600963 Genomic DNA. Translation: CAP35619.1 .
    RefSeqi XP_002642151.1. XM_002642105.1.

    3D structure databases

    ProteinModelPortali A8XT16.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG18105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG18105 ; CBG18105 ; CBG18105 .
    GeneIDi 8584146.
    KEGGi cbr:CBG18105.

    Organism-specific databases

    CTDi 8584146.
    WormBasei CBG18105 ; CBP10756 ; WBGene00037589 ; Cbr-gsto-2.

    Phylogenomic databases

    eggNOGi NOG288793.
    HOGENOMi HOG000006560.
    KOi K00799.
    OMAi HHSVYIN.
    OrthoDBi EOG71CFNG.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    PRINTSi PR01625. GSTRNSFRASEO.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiGSTO2_CAEBR
    AccessioniPrimary (citable) accession number: A8XT16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: January 15, 2008
    Last modified: May 14, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi