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A8XT16

- GSTO2_CAEBR

UniProt

A8XT16 - GSTO2_CAEBR

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Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351NucleophileBy similarity
Binding sitei62 – 621GlutathioneBy similarity
Binding sitei75 – 751Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase omega-2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:gsto-2Imported
ORF Names:CBG18105
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG18105; CBP10756; WBGene00037589; Cbr-gsto-2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Probable glutathione transferase omega-2PRO_0000352791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG18105.

Structurei

3D structure databases

ProteinModelPortaliA8XT16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10581GST N-terminalSequence AnalysisAdd
BLAST
Domaini110 – 238129GST C-terminalSequence AnalysisAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 902Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Sequence Analysis
Contains 1 GST C-terminal domain.Sequence Analysis
Contains 1 GST N-terminal domain.Sequence Analysis

Phylogenomic databases

eggNOGiNOG288793.
HOGENOMiHOG000006560.
InParanoidiA8XT16.
KOiK00799.
OMAiHHSVYIN.
OrthoDBiEOG71CFNG.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XT16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVLAGINSK VLKNGDSEPS PPPAGIYRIY NMRFCPWAQR ALIYASVKNV
60 70 80 90 100
PSEVINIHLK EKPDWYFSKH YKGQVPALEL DEGKKHVIES AHIPEYLDDL
110 120 130 140 150
FPESRILPSD PYEKVQQKLL LERLAAVAPA FYAAAQAANN PEGRDEKYAA
160 170 180 190 200
LVKAFEDAEK LLTGDFFSGK AKPGFADYLI FPNYQRVFWL SHILPNSPFS
210 220 230 240 250
SESFPGPNFP KLAKWYRTLD SIPEVAAASQ PTEMGVGFFN DYLKGTPNYD

YGL
Length:253
Mass (Da):28,451
Last modified:January 15, 2008 - v1
Checksum:i51F08F8D028C57A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600963 Genomic DNA. Translation: CAP35619.1.
RefSeqiXP_002642151.1. XM_002642105.1.

Genome annotation databases

EnsemblMetazoaiCBG18105; CBG18105; CBG18105.
GeneIDi8584146.
KEGGicbr:CBG18105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600963 Genomic DNA. Translation: CAP35619.1 .
RefSeqi XP_002642151.1. XM_002642105.1.

3D structure databases

ProteinModelPortali A8XT16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG18105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG18105 ; CBG18105 ; CBG18105 .
GeneIDi 8584146.
KEGGi cbr:CBG18105.

Organism-specific databases

CTDi 8584146.
WormBasei CBG18105 ; CBP10756 ; WBGene00037589 ; Cbr-gsto-2.

Phylogenomic databases

eggNOGi NOG288793.
HOGENOMi HOG000006560.
InParanoidi A8XT16.
KOi K00799.
OMAi HHSVYIN.
OrthoDBi EOG71CFNG.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01625. GSTRNSFRASEO.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiGSTO2_CAEBR
AccessioniPrimary (citable) accession number: A8XT16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3