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A8XRN3 (A8XRN3_CAEBR) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109
EC=1.1.1.44 PIRNR PIRNR000109
Gene names
ORF Names:CBG17632 WormBase CBG17632, CBG_17632 EMBL CAP35307.1
OrganismCaenorhabditis briggsae
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL CAP35307.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2601Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2871Substrate By similarity PIRSR PIRSR000109-2
Binding site4481Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4541Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
A8XRN3 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 203ACB2628D66982

FASTA48453,460
        10         20         30         40         50         60 
MAEADIAVIG LAVMGQNLIL NMNDHGFTVC AFNRTTKLVD DFLANEAKGT KIIGAHSIEE 

        70         80         90        100        110        120 
MCKKLKRPRR VMMLIKAGDA VDSMINQILP FLEKGDIIID GGNSDYNHSN RRYQELKEKG 

       130        140        150        160        170        180 
ISFVGCGVSG GEEGARFGPS LMPGGDPEAW PHIKDIFQKI AAKSNGEPCC DWVGNGGSGH 

       190        200        210        220        230        240 
FVKMVHNGIE YGDMQLIAEA FNLLSEAVEL NYDQMAEVMD DWNKGELESF LIEITANILK 

       250        260        270        280        290        300 
YRDEKGEPVV PKIRDSAGQK GTGKWTCIAA LEYGLPVTLI GEAVFARCLS ALKEERVYAS 

       310        320        330        340        350        360 
EHLSGPHVAP ETVIQDKRVF IKQISKALYA SKIVSYAQGF MLLAETSKQF NWDLNFGAIA 

       370        380        390        400        410        420 
LMWRGGCIIR SRFLGDIKRA FDNNKDLPNL LLDAFFTKAI SEANDSWRVV VGAAIRLEIP 

       430        440        450        460        470        480 
VPAFSSALAF YDGYKRKVLP ANLLQALRDY FGAHTYELLD QPGTWVHTNW TGKGGRVTSN 


TYNA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CAAC02000544 Genomic DNA. Translation: CAP35307.1.
RefSeqXP_002634295.1. XM_002634249.1.

3D structure databases

ProteinModelPortalA8XRN3.
SMRA8XRN3. Positions 2-475.
ModBaseSearch...

Protein-protein interaction databases

STRINGA8XRN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8576290.
KEGGcbr:CBG17632.

Organism-specific databases

CTD8576290.
WormBaseCBG17632; CBP04176; WBGene00037203.

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
PhylomeDBA8XRN3.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8XRN3_CAEBR
AccessionPrimary (citable) accession number: A8XRN3
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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