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A8XNF0

- ACAD1_CAEBR

UniProt

A8XNF0 - ACAD1_CAEBR

Protein

Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrial

Gene

CBG15946

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

    Catalytic activityi

    A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571Substrate; via carbonyl oxygenBy similarity
    Active sitei391 – 3911Proton acceptorBy similarity
    Binding sitei392 – 3921Substrate; via amide nitrogenBy similarity
    Binding sitei403 – 4031SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi148 – 15710FADBy similarity
    Nucleotide bindingi181 – 1833FADBy similarity
    Nucleotide bindingi296 – 2983FADBy similarity
    Nucleotide bindingi306 – 3072FADBy similarity
    Nucleotide bindingi364 – 3685FADBy similarity
    Nucleotide bindingi393 – 3953FADBy similarity

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00660.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarity (EC:1.3.8.7)
    Short name:
    MCADBy similarity
    Gene namesi
    ORF Names:CBG15946
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG15946; CBP23278; WBGene00036045.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1313MitochondrionSequence AnalysisAdd
    BLAST
    Chaini14 – 417404Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarityPRO_0000395327Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG15946.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XNF0.
    SMRiA8XNF0. Positions 28-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni268 – 2714Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the acyl-CoA dehydrogenase family.Sequence Analysis

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000131659.
    KOiK00249.
    OMAiSAWEVDQ.
    OrthoDBiEOG74FF0S.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8XNF0-1 [UniParc]FASTAAdd to Basket

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    MLSRFATTSL GLSRSATGVL ASQSRQISFD LSDTQKEIQA AALKFSKEVL    50
    VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE 100
    ALSYGCTGLQ LGIMGPSLAI APVYIAGNEE QKKKYLGALA AEPIIASYCV 150
    TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDSD 200
    PKAPAGKAFT AFIVDGDTPG ISRGKKEKNM GQRCSDTRTI TFEDVRVPAE 250
    NVLGAPGAGF KVAMGAFDMT RPGVAAGALG LAWRCLDESA KYALQRKAFG 300
    TEIANHQAVQ FMLADMAVNL ELARLITYKS ATDVDNKVRS SYNASIAKCF 350
    AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV 400
    ISRMLLGHFA QNGTSRI 417
    Length:417
    Mass (Da):44,669
    Last modified:January 15, 2008 - v1
    Checksum:iA21A018375E2C863
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600995 Genomic DNA. Translation: CAP34381.1.
    RefSeqiXP_002643349.1. XM_002643303.1.

    Genome annotation databases

    EnsemblMetazoaiCBG15946; CBG15946; CBG15946.
    GeneIDi8585343.
    KEGGicbr:CBG15946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600995 Genomic DNA. Translation: CAP34381.1 .
    RefSeqi XP_002643349.1. XM_002643303.1.

    3D structure databases

    ProteinModelPortali A8XNF0.
    SMRi A8XNF0. Positions 28-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG15946.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG15946 ; CBG15946 ; CBG15946 .
    GeneIDi 8585343.
    KEGGi cbr:CBG15946.

    Organism-specific databases

    CTDi 8585343.
    WormBasei CBG15946 ; CBP23278 ; WBGene00036045 .

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000131659.
    KOi K00249.
    OMAi SAWEVDQ.
    OrthoDBi EOG74FF0S.

    Enzyme and pathway databases

    UniPathwayi UPA00660 .

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiACAD1_CAEBR
    AccessioniPrimary (citable) accession number: A8XNF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3