Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrial

Gene

CBG15946

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157Substrate; via carbonyl oxygenBy similarity1
Active sitei391Proton acceptorBy similarity1
Binding sitei392Substrate; via amide nitrogenBy similarity1
Binding sitei403SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 157FADBy similarity10
Nucleotide bindingi181 – 183FADBy similarity3
Nucleotide bindingi296 – 298FADBy similarity3
Nucleotide bindingi306 – 307FADBy similarity2
Nucleotide bindingi364 – 368FADBy similarity5
Nucleotide bindingi393 – 395FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarity (EC:1.3.8.7)
Short name:
MCADBy similarity
Gene namesi
ORF Names:CBG15946
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG15946 ; CBP23278 ; WBGene00036045

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionSequence analysisAdd BLAST13
ChainiPRO_000039532714 – 417Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarityAdd BLAST404

Proteomic databases

PRIDEiA8XNF0

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi6238.CBG15946

Structurei

3D structure databases

ProteinModelPortaliA8XNF0
SMRiA8XNF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 271Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
HOGENOMiHOG000131659
InParanoidiA8XNF0
KOiK00249
OMAiCPPSKAF
OrthoDBiEOG091G04BS

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XNF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRFATTSL GLSRSATGVL ASQSRQISFD LSDTQKEIQA AALKFSKEVL
60 70 80 90 100
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE
110 120 130 140 150
ALSYGCTGLQ LGIMGPSLAI APVYIAGNEE QKKKYLGALA AEPIIASYCV
160 170 180 190 200
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDSD
210 220 230 240 250
PKAPAGKAFT AFIVDGDTPG ISRGKKEKNM GQRCSDTRTI TFEDVRVPAE
260 270 280 290 300
NVLGAPGAGF KVAMGAFDMT RPGVAAGALG LAWRCLDESA KYALQRKAFG
310 320 330 340 350
TEIANHQAVQ FMLADMAVNL ELARLITYKS ATDVDNKVRS SYNASIAKCF
360 370 380 390 400
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV
410
ISRMLLGHFA QNGTSRI
Length:417
Mass (Da):44,669
Last modified:January 15, 2008 - v1
Checksum:iA21A018375E2C863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600995 Genomic DNA Translation: CAP34381.1
RefSeqiXP_002643349.1, XM_002643303.1

Genome annotation databases

EnsemblMetazoaiCBG15946; CBG15946; WBGene00036045
GeneIDi8585343
KEGGicbr:CBG15946

Similar proteinsi

Entry informationi

Entry nameiACAD1_CAEBR
AccessioniPrimary (citable) accession number: A8XNF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health