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A8XNF0

- ACAD1_CAEBR

UniProt

A8XNF0 - ACAD1_CAEBR

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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrial

Gene
CBG15946
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16 By similarity.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Substrate; via carbonyl oxygen By similarityBy similarity
Active sitei391 – 3911Proton acceptor By similarityBy similarity
Binding sitei392 – 3921Substrate; via amide nitrogen By similarityBy similarity
Binding sitei403 – 4031Substrate By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 15710FAD By similarityBy similarity
Nucleotide bindingi181 – 1833FAD By similarityBy similarity
Nucleotide bindingi296 – 2983FAD By similarityBy similarity
Nucleotide bindingi306 – 3072FAD By similarityBy similarity
Nucleotide bindingi364 – 3685FAD By similarityBy similarity
Nucleotide bindingi393 – 3953FAD By similarityBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
ORF Names:CBG15946
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG15946; CBP23278; WBGene00036045.

Subcellular locationi

Mitochondrion matrix By similarity By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313Mitochondrion Reviewed predictionAdd
BLAST
Chaini14 – 417404Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarityPRO_0000395327Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.By similarity

Protein-protein interaction databases

STRINGi6238.CBG15946.

Structurei

3D structure databases

ProteinModelPortaliA8XNF0.
SMRiA8XNF0. Positions 28-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2714Substrate binding By similarityBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
KOiK00249.
OMAiSAWEVDQ.
OrthoDBiEOG74FF0S.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XNF0-1 [UniParc]FASTAAdd to Basket

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MLSRFATTSL GLSRSATGVL ASQSRQISFD LSDTQKEIQA AALKFSKEVL    50
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE 100
ALSYGCTGLQ LGIMGPSLAI APVYIAGNEE QKKKYLGALA AEPIIASYCV 150
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDSD 200
PKAPAGKAFT AFIVDGDTPG ISRGKKEKNM GQRCSDTRTI TFEDVRVPAE 250
NVLGAPGAGF KVAMGAFDMT RPGVAAGALG LAWRCLDESA KYALQRKAFG 300
TEIANHQAVQ FMLADMAVNL ELARLITYKS ATDVDNKVRS SYNASIAKCF 350
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV 400
ISRMLLGHFA QNGTSRI 417
Length:417
Mass (Da):44,669
Last modified:January 15, 2008 - v1
Checksum:iA21A018375E2C863
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600995 Genomic DNA. Translation: CAP34381.1.
RefSeqiXP_002643349.1. XM_002643303.1.

Genome annotation databases

EnsemblMetazoaiCBG15946; CBG15946; CBG15946.
GeneIDi8585343.
KEGGicbr:CBG15946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600995 Genomic DNA. Translation: CAP34381.1 .
RefSeqi XP_002643349.1. XM_002643303.1.

3D structure databases

ProteinModelPortali A8XNF0.
SMRi A8XNF0. Positions 28-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG15946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG15946 ; CBG15946 ; CBG15946 .
GeneIDi 8585343.
KEGGi cbr:CBG15946.

Organism-specific databases

CTDi 8585343.
WormBasei CBG15946 ; CBP23278 ; WBGene00036045 .

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
KOi K00249.
OMAi SAWEVDQ.
OrthoDBi EOG74FF0S.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACAD1_CAEBR
AccessioniPrimary (citable) accession number: A8XNF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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