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A8XNF0

- ACAD1_CAEBR

UniProt

A8XNF0 - ACAD1_CAEBR

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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrial

Gene

CBG15946

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Substrate; via carbonyl oxygenBy similarity
Active sitei391 – 3911Proton acceptorBy similarity
Binding sitei392 – 3921Substrate; via amide nitrogenBy similarity
Binding sitei403 – 4031SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 15710FADBy similarity
Nucleotide bindingi181 – 1833FADBy similarity
Nucleotide bindingi296 – 2983FADBy similarity
Nucleotide bindingi306 – 3072FADBy similarity
Nucleotide bindingi364 – 3685FADBy similarity
Nucleotide bindingi393 – 3953FADBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarity (EC:1.3.8.7)
Short name:
MCADBy similarity
Gene namesi
ORF Names:CBG15946
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG15946; CBP23278; WBGene00036045.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionSequence AnalysisAdd
BLAST
Chaini14 – 417404Probable medium-chain specific acyl-CoA dehydrogenase 1, mitochondrialBy similarityPRO_0000395327Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi6238.CBG15946.

Structurei

3D structure databases

ProteinModelPortaliA8XNF0.
SMRiA8XNF0. Positions 28-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2714Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Sequence Analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
InParanoidiA8XNF0.
KOiK00249.
OMAiSAWEVDQ.
OrthoDBiEOG74FF0S.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XNF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRFATTSL GLSRSATGVL ASQSRQISFD LSDTQKEIQA AALKFSKEVL
60 70 80 90 100
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE
110 120 130 140 150
ALSYGCTGLQ LGIMGPSLAI APVYIAGNEE QKKKYLGALA AEPIIASYCV
160 170 180 190 200
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDSD
210 220 230 240 250
PKAPAGKAFT AFIVDGDTPG ISRGKKEKNM GQRCSDTRTI TFEDVRVPAE
260 270 280 290 300
NVLGAPGAGF KVAMGAFDMT RPGVAAGALG LAWRCLDESA KYALQRKAFG
310 320 330 340 350
TEIANHQAVQ FMLADMAVNL ELARLITYKS ATDVDNKVRS SYNASIAKCF
360 370 380 390 400
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV
410
ISRMLLGHFA QNGTSRI
Length:417
Mass (Da):44,669
Last modified:January 15, 2008 - v1
Checksum:iA21A018375E2C863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600995 Genomic DNA. Translation: CAP34381.1.
RefSeqiXP_002643349.1. XM_002643303.1.

Genome annotation databases

EnsemblMetazoaiCBG15946; CBG15946; CBG15946.
GeneIDi8585343.
KEGGicbr:CBG15946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600995 Genomic DNA. Translation: CAP34381.1 .
RefSeqi XP_002643349.1. XM_002643303.1.

3D structure databases

ProteinModelPortali A8XNF0.
SMRi A8XNF0. Positions 28-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG15946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG15946 ; CBG15946 ; CBG15946 .
GeneIDi 8585343.
KEGGi cbr:CBG15946.

Organism-specific databases

CTDi 8585343.
WormBasei CBG15946 ; CBP23278 ; WBGene00036045 .

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
InParanoidi A8XNF0.
KOi K00249.
OMAi SAWEVDQ.
OrthoDBi EOG74FF0S.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiACAD1_CAEBR
AccessioniPrimary (citable) accession number: A8XNF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3