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A8XKT0

- KYNU_CAEBR

UniProt

A8XKT0 - KYNU_CAEBR

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Protein

Kynureninase

Gene

flu-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei154 – 1541Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei155 – 1551Pyridoxal phosphateUniRule annotation
Binding sitei238 – 2381Pyridoxal phosphateUniRule annotation
Binding sitei267 – 2671Pyridoxal phosphateUniRule annotation
Binding sitei270 – 2701Pyridoxal phosphateUniRule annotation
Binding sitei292 – 2921Pyridoxal phosphateUniRule annotation
Binding sitei322 – 3221Pyridoxal phosphateUniRule annotation
Binding sitei350 – 3501Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Abnormal fluorescence under UV illumination
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:flu-2
ORF Names:CBG14833
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG14833; CBP18263; WBGene00035224; Cbr-flu-2.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483KynureninasePRO_0000356959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei293 – 2931N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi6238.CBG14833.

Structurei

3D structure databases

ProteinModelPortaliA8XKT0.
SMRiA8XKT0. Positions 28-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 1854Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
InParanoidiA8XKT0.
KOiK01556.
OMAiHVAYRSA.
OrthoDBiEOG7D2FDV.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A8XKT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEGQAPAPP QPEGDQECMC TQDKVLQFLN KMADESGIKD LTDPALAEFL
60 70 80 90 100
TDSDALKGIR DLFHYPKAGT LPDVDPTLVD PNADSIYLCG NSLGLMPKVT
110 120 130 140 150
EEVMKEHLDK WAKMGVFGHM TGEVPWAHSD EHCLEGVGRL VGAKKEEVSI
160 170 180 190 200
ANSLTVNIHV LLTAFYKPTE TRHKILLESK AFPSDHYAIE SQIRLKGRTV
210 220 230 240 250
EESMVCMEPR EGEETLRTED IIDYIENNGD EIAIVFFSGI QYYTGQLFDI
260 270 280 290 300
KAITEAGHRK GCLVGWDLAH AFANVPLHLH WWDVDFAAWC SYKYGCTGAG
310 320 330 340 350
SIAGLFVHER FLHDKRDRML GWWSHKMSSR FTMDNVLDLD EGAAGYRISN
360 370 380 390 400
PPIHCVAAML GSLKIFDQVS LENLRSRSCY LTGYLEYLVK TLFGENSEQR
410 420 430 440 450
TTKLSILIIT PENFHQRGCQ LSLKFSSPID VIYPELVKRG VAVDKRYPNV
460 470 480
IRVAPVHLYN NYVDVRRFIS VLQEVAHIVE DHA
Length:483
Mass (Da):54,408
Last modified:January 15, 2008 - v1
Checksum:iF7BD3B8CB98C956A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600983 Genomic DNA. Translation: CAP33254.1.
RefSeqiXP_002644815.1. XM_002644769.1.

Genome annotation databases

EnsemblMetazoaiCBG14833; CBG14833; CBG14833.
GeneIDi8586811.
KEGGicbr:CBG14833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600983 Genomic DNA. Translation: CAP33254.1 .
RefSeqi XP_002644815.1. XM_002644769.1.

3D structure databases

ProteinModelPortali A8XKT0.
SMRi A8XKT0. Positions 28-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG14833.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG14833 ; CBG14833 ; CBG14833 .
GeneIDi 8586811.
KEGGi cbr:CBG14833.

Organism-specific databases

CTDi 8586811.
WormBasei CBG14833 ; CBP18263 ; WBGene00035224 ; Cbr-flu-2.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
InParanoidi A8XKT0.
KOi K01556.
OMAi HVAYRSA.
OrthoDBi EOG7D2FDV.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiKYNU_CAEBR
AccessioniPrimary (citable) accession number: A8XKT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3