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A8XKT0

- KYNU_CAEBR

UniProt

A8XKT0 - KYNU_CAEBR

Protein

Kynureninase

Gene

flu-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei154 – 1541Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei155 – 1551Pyridoxal phosphateUniRule annotation
    Binding sitei238 – 2381Pyridoxal phosphateUniRule annotation
    Binding sitei267 – 2671Pyridoxal phosphateUniRule annotation
    Binding sitei270 – 2701Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Pyridoxal phosphateUniRule annotation
    Binding sitei322 – 3221Pyridoxal phosphateUniRule annotation
    Binding sitei350 – 3501Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Abnormal fluorescence under UV illumination
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:flu-2
    ORF Names:CBG14833
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG14833; CBP18263; WBGene00035224; Cbr-flu-2.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483KynureninasePRO_0000356959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei293 – 2931N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi6238.CBG14833.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XKT0.
    SMRiA8XKT0. Positions 28-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni182 – 1854Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiHVAYRSA.
    OrthoDBiEOG7D2FDV.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8XKT0-1 [UniParc]FASTAAdd to Basket

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    MAEGQAPAPP QPEGDQECMC TQDKVLQFLN KMADESGIKD LTDPALAEFL    50
    TDSDALKGIR DLFHYPKAGT LPDVDPTLVD PNADSIYLCG NSLGLMPKVT 100
    EEVMKEHLDK WAKMGVFGHM TGEVPWAHSD EHCLEGVGRL VGAKKEEVSI 150
    ANSLTVNIHV LLTAFYKPTE TRHKILLESK AFPSDHYAIE SQIRLKGRTV 200
    EESMVCMEPR EGEETLRTED IIDYIENNGD EIAIVFFSGI QYYTGQLFDI 250
    KAITEAGHRK GCLVGWDLAH AFANVPLHLH WWDVDFAAWC SYKYGCTGAG 300
    SIAGLFVHER FLHDKRDRML GWWSHKMSSR FTMDNVLDLD EGAAGYRISN 350
    PPIHCVAAML GSLKIFDQVS LENLRSRSCY LTGYLEYLVK TLFGENSEQR 400
    TTKLSILIIT PENFHQRGCQ LSLKFSSPID VIYPELVKRG VAVDKRYPNV 450
    IRVAPVHLYN NYVDVRRFIS VLQEVAHIVE DHA 483
    Length:483
    Mass (Da):54,408
    Last modified:January 15, 2008 - v1
    Checksum:iF7BD3B8CB98C956A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP33254.1.
    RefSeqiXP_002644815.1. XM_002644769.1.

    Genome annotation databases

    EnsemblMetazoaiCBG14833; CBG14833; CBG14833.
    GeneIDi8586811.
    KEGGicbr:CBG14833.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600983 Genomic DNA. Translation: CAP33254.1 .
    RefSeqi XP_002644815.1. XM_002644769.1.

    3D structure databases

    ProteinModelPortali A8XKT0.
    SMRi A8XKT0. Positions 28-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG14833.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG14833 ; CBG14833 ; CBG14833 .
    GeneIDi 8586811.
    KEGGi cbr:CBG14833.

    Organism-specific databases

    CTDi 8586811.
    WormBasei CBG14833 ; CBP18263 ; WBGene00035224 ; Cbr-flu-2.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi HVAYRSA.
    OrthoDBi EOG7D2FDV.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiKYNU_CAEBR
    AccessioniPrimary (citable) accession number: A8XKT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3