Reviewed, UniProtKB/Swiss-Prot A8XJ44 (OXDA2_CAEBR)

Names and origin

Protein names

Recommended name:
    D-amino-acid oxidase 2
      Short name=DAMOX 2
      Short name=DAAO 2
      Short name=DAO 2
    EC=1.4.3.3

Gene names

Name:

CBG13882

Organism

Caenorhabditis briggsae [Complete proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids By similarity. UniProtKB P14920
Catalytic activity	A D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD By similarity. UniProtKB P14920
Subunit structure	Homodimer By similarity. UniProtKB P14920
Subcellular location	Peroxisome By similarity. UniProtKB P14920
Sequence similarities	Belongs to the DAMOX/DASOX family.
Sequence caution	The sequence CAP32671.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Peroxisome
Domain	Signal
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-amino-acid oxidase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 329	310	D-amino-acid oxidase 2		PRO_0000317124
Regions
	Nucleotide binding	4 – 18	15	FAD By similarity UniProtKB P14920
	Nucleotide binding	34 – 35	2	FAD By similarity
	Nucleotide binding	41 – 42	2	FAD By similarity
	Nucleotide binding	46 – 48	3	FAD By similarity
	Nucleotide binding	298 – 302	5	FAD By similarity
	Motif	327 – 329	3	Microbody targeting signal Potential
Sites
	Binding site	162	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	182	1	FAD By similarity
	Binding site	220	1	Substrate By similarity
	Binding site	275	1	Substrate By similarity
	Binding site	299	1	Substrate; via carbonyl oxygen By similarity
	Binding site	303	1	FAD By similarity
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	224	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A8XJ44-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 6D7B7F6CE3625886	FASTA	329	36,808
	10 20 30 40 50 60 MPRICVLGAG IMGVSTALAI QERIPDSVVT IIAEKFSPNT TSDVAAGLIE PYLCDDDVDR 70 80 90 100 110 120 VISWTKSTIQ RIQEYMNEGN PGAESQEQSG YWLQSVKSVP KWLEVMKNVK ILTGNELKMV 130 140 150 160 170 180 AKRPEHKFGI FYTTWYLEPT PYIKWESDKF LKNGGKIKNS KIQKIEDVEK EFGLFDVILN 190 200 210 220 230 240 CTGIGARHLI GDNEVFPTRG QILKVKCPSV KHFFIDDQFY ALLNDTTITL GGTADRHQWD 250 260 270 280 290 300 RTINPKISEK IFQENCKNIP SLRSAQVISS HVDLRPSRVT VRLEAEPDSK VIHNNGHGGS 310 320 GITLHWGCAL ECVELVKKVL AGKPGISKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.
[2]	The C.briggsae Sequencing Consortium Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. Strain: AF16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CAAC02000520 Genomic DNA. Translation: CAP32671.2. Sequence problems.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus CBG13882 in contig CU538967_GR.
Organism-specific databases
WormBase	WBGene00034568. CBG13882.
Phylogenomic databases
OMA	RYISTEY.
Enzyme and pathway databases
BRENDA	1.4.3.3. 261794.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OXDA2_CAEBR

Accession

Primary (citable) accession number: A8XJ44

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 15, 2008
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project