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A8XI74

- CED2_CAEBR

UniProt

A8XI74 - CED2_CAEBR

Protein

Cell death abnormality protein 2

Gene

ced-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) By similarity.By similarity

    GO - Molecular functioni

    1. protein complex binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. apoptotic process Source: UniProtKB
    3. cell migration Source: UniProtKB
    4. engulfment of apoptotic cell Source: UniProtKB
    5. signal transduction Source: UniProtKB

    Keywords - Biological processi

    Phagocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell death abnormality protein 2By similarity
    Gene namesi
    Name:ced-2Imported
    ORF Names:CBG13568
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG13568; CBP03281; WBGene00034318; Cbr-ced-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Cell death abnormality protein 2PRO_0000379933Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region). Forms a ternary complex with ced-5 and ced-12 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG13568.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XI74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 11299SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini113 – 17361SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini214 – 27562SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRK family.Sequence Analysis
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG292767.
    HOGENOMiHOG000236288.
    KOiK04438.
    OMAiHPRFRIG.
    OrthoDBiEOG7NW69P.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XI74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNMNGFDPFE WRSFYFPGMS REDAHKLLGE PRVSIGTFLM RDSSQPGEYS    50
    LSVREADEGN TVCHYLIVRD VKEDGTAGVK IAEQSFPDIP ALLNHFKMRV 100
    LTEASLLSAY KKPIIEVVVG TFKFTGERET DLPFEQGERL EILSKTNNDW 150
    WEARNALGTT GLVPANYVQV QSGEFANERI SKGTSQSSIG SSGNGAERFS 200
    STSTSSENAE AHPTLPTTAK VTFDRVPNAY DPTQLRVKKG QTVRVLEKMS 250
    NGMYRAELDG QIGSVPFTYI RFNTANQ 277
    Length:277
    Mass (Da):30,797
    Last modified:January 15, 2008 - v1
    Checksum:i6FEBCDB7B563AB82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600980 Genomic DNA. Translation: CAP32348.1.
    RefSeqiXP_002635024.1. XM_002634978.1.

    Genome annotation databases

    EnsemblMetazoaiCBG13568; CBG13568; CBG13568.
    GeneIDi8577019.
    KEGGicbr:CBG13568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600980 Genomic DNA. Translation: CAP32348.1 .
    RefSeqi XP_002635024.1. XM_002634978.1.

    3D structure databases

    ProteinModelPortali A8XI74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG13568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG13568 ; CBG13568 ; CBG13568 .
    GeneIDi 8577019.
    KEGGi cbr:CBG13568.

    Organism-specific databases

    CTDi 8577019.
    WormBasei CBG13568 ; CBP03281 ; WBGene00034318 ; Cbr-ced-2.

    Phylogenomic databases

    eggNOGi NOG292767.
    HOGENOMi HOG000236288.
    KOi K04438.
    OMAi HPRFRIG.
    OrthoDBi EOG7NW69P.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiCED2_CAEBR
    AccessioniPrimary (citable) accession number: A8XI74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3