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A8XI74 (CED2_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell death abnormality protein 2
Gene names
Name:ced-2
ORF Names:CBG13568
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) By similarity. UniProtKB Q9NHC3

Subunit structure

Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region). Forms a ternary complex with ced-5 and ced-12 By similarity. UniProtKB Q9NHC3

Sequence similarities

Belongs to the CRK family.

Contains 1 SH2 domain.

Contains 2 SH3 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Cell death abnormality protein 2
PRO_0000379933

Regions

Domain14 – 11299SH2
Domain113 – 17361SH3 1
Domain214 – 27562SH3 2

Sequences

Sequence LengthMass (Da)Tools
A8XI74 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 6FEBCDB7B563AB82

FASTA27730,797
        10         20         30         40         50         60 
MNMNGFDPFE WRSFYFPGMS REDAHKLLGE PRVSIGTFLM RDSSQPGEYS LSVREADEGN 

        70         80         90        100        110        120 
TVCHYLIVRD VKEDGTAGVK IAEQSFPDIP ALLNHFKMRV LTEASLLSAY KKPIIEVVVG 

       130        140        150        160        170        180 
TFKFTGERET DLPFEQGERL EILSKTNNDW WEARNALGTT GLVPANYVQV QSGEFANERI 

       190        200        210        220        230        240 
SKGTSQSSIG SSGNGAERFS STSTSSENAE AHPTLPTTAK VTFDRVPNAY DPTQLRVKKG 

       250        260        270 
QTVRVLEKMS NGMYRAELDG QIGSVPFTYI RFNTANQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600980 Genomic DNA. Translation: CAP32348.1.
RefSeqXP_002635024.1. XM_002634978.1.

3D structure databases

ProteinModelPortalA8XI74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG13568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG13568; CBG13568; CBG13568.
GeneID8577019.
KEGGcbr:CBG13568.

Organism-specific databases

CTD8577019.
WormBaseCBG13568; CBP03281; WBGene00034318; Cbr-ced-2.

Phylogenomic databases

eggNOGNOG292767.
HOGENOMHOG000236288.
KOK04438.
OMAWWNAQNS.
OrthoDBEOG7NW69P.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCED2_CAEBR
AccessionPrimary (citable) accession number: A8XI74
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families