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Protein

Cell death abnormality protein 2

Gene

ced-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPhagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death abnormality protein 2By similarity
Gene namesi
Name:ced-2Imported
ORF Names:CBG13568
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome IV, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG13568 ; CBP03281 ; WBGene00034318 ; Cbr-ced-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003799331 – 277Cell death abnormality protein 2Add BLAST277

Interactioni

Subunit structurei

Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region). Forms a ternary complex with ced-5 and ced-12. Interacts (via SH-2 domain) with src-1 (when activated and phosphorylated at 'Tyr-416').By similarity

Protein-protein interaction databases

STRINGi6238.CBG13568

Structurei

3D structure databases

ProteinModelPortaliA8XI74
SMRiA8XI74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 112SH2PROSITE-ProRule annotationAdd BLAST99
Domaini113 – 173SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini214 – 275SH3 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CRK family.Sequence analysis

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792 Eukaryota
ENOG4110574 LUCA
HOGENOMiHOG000236288
InParanoidiA8XI74
KOiK04438
OMAiFPGMSRE
OrthoDBiEOG091G0JPQ

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

A8XI74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMNGFDPFE WRSFYFPGMS REDAHKLLGE PRVSIGTFLM RDSSQPGEYS
60 70 80 90 100
LSVREADEGN TVCHYLIVRD VKEDGTAGVK IAEQSFPDIP ALLNHFKMRV
110 120 130 140 150
LTEASLLSAY KKPIIEVVVG TFKFTGERET DLPFEQGERL EILSKTNNDW
160 170 180 190 200
WEARNALGTT GLVPANYVQV QSGEFANERI SKGTSQSSIG SSGNGAERFS
210 220 230 240 250
STSTSSENAE AHPTLPTTAK VTFDRVPNAY DPTQLRVKKG QTVRVLEKMS
260 270
NGMYRAELDG QIGSVPFTYI RFNTANQ
Length:277
Mass (Da):30,797
Last modified:January 15, 2008 - v1
Checksum:i6FEBCDB7B563AB82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600980 Genomic DNA Translation: CAP32348.1
RefSeqiXP_002635024.1, XM_002634978.1

Genome annotation databases

EnsemblMetazoaiCBG13568; CBG13568; WBGene00034318
GeneIDi8577019
KEGGicbr:CBG13568

Similar proteinsi

Entry informationi

Entry nameiCED2_CAEBR
AccessioniPrimary (citable) accession number: A8XI74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health