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Protein

Cell death abnormality protein 2

Gene

ced-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death abnormality protein 2By similarity
Gene namesi
Name:ced-2Imported
ORF Names:CBG13568
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome IV, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG13568; CBP03281; WBGene00034318; Cbr-ced-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003799331 – 277Cell death abnormality protein 2Add BLAST277

Interactioni

Subunit structurei

Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region). Forms a ternary complex with ced-5 and ced-12. Interacts (via SH-2 domain) with src-1 (when activated and phosphorylated at 'Tyr-416').By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6238.CBG13568.

Structurei

3D structure databases

ProteinModelPortaliA8XI74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 112SH2PROSITE-ProRule annotationAdd BLAST99
Domaini113 – 173SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini214 – 275SH3 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CRK family.Sequence analysis
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
HOGENOMiHOG000236288.
InParanoidiA8XI74.
KOiK04438.
OMAiKMSNGMY.
OrthoDBiEOG091G0JPQ.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XI74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMNGFDPFE WRSFYFPGMS REDAHKLLGE PRVSIGTFLM RDSSQPGEYS
60 70 80 90 100
LSVREADEGN TVCHYLIVRD VKEDGTAGVK IAEQSFPDIP ALLNHFKMRV
110 120 130 140 150
LTEASLLSAY KKPIIEVVVG TFKFTGERET DLPFEQGERL EILSKTNNDW
160 170 180 190 200
WEARNALGTT GLVPANYVQV QSGEFANERI SKGTSQSSIG SSGNGAERFS
210 220 230 240 250
STSTSSENAE AHPTLPTTAK VTFDRVPNAY DPTQLRVKKG QTVRVLEKMS
260 270
NGMYRAELDG QIGSVPFTYI RFNTANQ
Length:277
Mass (Da):30,797
Last modified:January 15, 2008 - v1
Checksum:i6FEBCDB7B563AB82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600980 Genomic DNA. Translation: CAP32348.1.
RefSeqiXP_002635024.1. XM_002634978.1.

Genome annotation databases

EnsemblMetazoaiCBG13568; CBG13568; WBGene00034318.
GeneIDi8577019.
KEGGicbr:CBG13568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600980 Genomic DNA. Translation: CAP32348.1.
RefSeqiXP_002635024.1. XM_002634978.1.

3D structure databases

ProteinModelPortaliA8XI74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG13568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG13568; CBG13568; WBGene00034318.
GeneIDi8577019.
KEGGicbr:CBG13568.

Organism-specific databases

CTDi8577019.
WormBaseiCBG13568; CBP03281; WBGene00034318; Cbr-ced-2.

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
HOGENOMiHOG000236288.
InParanoidiA8XI74.
KOiK04438.
OMAiKMSNGMY.
OrthoDBiEOG091G0JPQ.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCED2_CAEBR
AccessioniPrimary (citable) accession number: A8XI74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.