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A8XGS6

- MTAP_CAEBR

UniProt

A8XGS6 - MTAP_CAEBR

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

CBG12968

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101PhosphateUniRule annotation
    Sitei170 – 1701Important for substrate specificityUniRule annotation
    Binding sitei188 – 1881Substrate; via amide nitrogenUniRule annotation
    Binding sitei189 – 1891PhosphateUniRule annotation
    Sitei224 – 2241Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    ORF Names:CBG12968
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG12968; CBP22764; WBGene00033820.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285S-methyl-5'-thioadenosine phosphorylasePRO_0000415122Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi6238.CBG12968.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XGS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 532Phosphate bindingUniRule annotation
    Regioni85 – 862Phosphate bindingUniRule annotation
    Regioni212 – 2143Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiCEAQLCY.
    OrthoDBiEOG771270.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XGS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKVGIIGGS GLEDPNILLN PTAISIDTPY GQPSDHLIQG TINGVECVLL    50
    ARHGRKHDIM PGNVNYRANL WALYSLGVDV IIASTACGSL KEEVAPGHLL 100
    FPDSVFDRTN SRKATFFDGT FSGAPGVSHI QAHPTYNEKL RQVLISTAEK 150
    CKLVHHRTGF GVCIEGPRFS TKAESMVFKS WGASLVNMTM MPECILAKEL 200
    GIPYATTALV TDYDCWKDED QVTAASVMKV FAANVEKAKT LFIEAVAEIG 250
    KIDWSAEILQ TKTAARQSIM ISPDVEVEFL KVPKT 285
    Length:285
    Mass (Da):31,011
    Last modified:January 15, 2008 - v1
    Checksum:i2156DCAD3564F43F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600938 Genomic DNA. Translation: CAP31850.1.
    RefSeqiXP_002630529.1. XM_002630483.1.

    Genome annotation databases

    EnsemblMetazoaiCBG12968; CBG12968; CBG12968.
    GeneIDi8572045.
    KEGGicbr:CBG12968.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600938 Genomic DNA. Translation: CAP31850.1 .
    RefSeqi XP_002630529.1. XM_002630483.1.

    3D structure databases

    ProteinModelPortali A8XGS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG12968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG12968 ; CBG12968 ; CBG12968 .
    GeneIDi 8572045.
    KEGGi cbr:CBG12968.

    Organism-specific databases

    CTDi 8572045.
    WormBasei CBG12968 ; CBP22764 ; WBGene00033820 .

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi CEAQLCY.
    OrthoDBi EOG771270.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiMTAP_CAEBR
    AccessioniPrimary (citable) accession number: A8XGS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3