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A8XGS6 (MTAP_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Short name=MTAPase
Gene names
ORF Names:CBG12968
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_03155

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_03155

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_03155

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_03155

Subcellular location

Cytoplasm By similarity. Nucleus By similarity HAMAP-Rule MF_03155.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
Nucleus
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-methionine salvage from methylthioadenosine

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionS-methyl-5-thioadenosine phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

phosphorylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_03155
PRO_0000415122

Regions

Region52 – 532Phosphate binding By similarity
Region85 – 862Phosphate binding By similarity
Region212 – 2143Substrate binding By similarity

Sites

Binding site101Phosphate By similarity
Binding site1881Substrate; via amide nitrogen By similarity
Binding site1891Phosphate By similarity
Site1701Important for substrate specificity By similarity
Site2241Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
A8XGS6 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 2156DCAD3564F43F

FASTA28531,011
        10         20         30         40         50         60 
MVKVGIIGGS GLEDPNILLN PTAISIDTPY GQPSDHLIQG TINGVECVLL ARHGRKHDIM 

        70         80         90        100        110        120 
PGNVNYRANL WALYSLGVDV IIASTACGSL KEEVAPGHLL FPDSVFDRTN SRKATFFDGT 

       130        140        150        160        170        180 
FSGAPGVSHI QAHPTYNEKL RQVLISTAEK CKLVHHRTGF GVCIEGPRFS TKAESMVFKS 

       190        200        210        220        230        240 
WGASLVNMTM MPECILAKEL GIPYATTALV TDYDCWKDED QVTAASVMKV FAANVEKAKT 

       250        260        270        280 
LFIEAVAEIG KIDWSAEILQ TKTAARQSIM ISPDVEVEFL KVPKT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600938 Genomic DNA. Translation: CAP31850.1.
RefSeqXP_002630529.1. XM_002630483.1.

3D structure databases

ProteinModelPortalA8XGS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG12968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG12968; CBG12968; CBG12968.
GeneID8572045.
KEGGcbr:CBG12968.

Organism-specific databases

CTD8572045.
WormBaseCBG12968; CBP22764; WBGene00033820.

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000228987.
KOK00772.
OMAMTNHTEA.
OrthoDBEOG771270.

Enzyme and pathway databases

UniPathwayUPA00904; UER00873.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTAP_CAEBR
AccessionPrimary (citable) accession number: A8XGS6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways