A8XFH3 (EIF3E_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 3 subunit E
Short name=eIF3e

Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6

Gene names

Name:	eif-3.E
ORF Names:	CBG12457

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome By similarity. HAMAP-Rule MF_03004
Subunit structure	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eIF-3 subunit E family. Contains 1 PCI domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Eukaryotic translation initiation factor 3 subunit E HAMAP-Rule MF_03004		PRO_0000365977
Regions
	Domain	167 – 273	107	PCI

Sequences

	Sequence		Length	Mass (Da)
	A8XFH3 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 82AFD4D0196BD7C6	FASTA	311	36,685
	10 20 30 40 50 60 MFTVDMVDTL FKYSKFMYEC GNYTVASVCL YYYRNLVNQA DPNYLNALYG KLASEILLQE 70 80 90 100 110 120 WEHARDDLLK LRAYIDANPF DTEWELVTQR AWLMHWALFV YYNYPKGRDE IIEMFLNQQP 130 140 150 160 170 180 YLNAIQVLAP HLLRYLAVAV VTSKSRQKNS LKDLVKVIDI ERHSYKDPVT DFLTCLYIKY 190 200 210 220 230 240 DFDEAQEMLQ KCEEVLSNDF FLTAVLGDFR ESARLLIFEM FCRIHQCITI EMLARRLNMS 250 260 270 280 290 300 QEEAERWIVD LIRTYRIEGA KIDSKLGQVV MGVKSVSIHE QVMENTKRLT LRAQQIALQL 310 EKGRQDKVKA N

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600913 Genomic DNA. Translation: CAP31434.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	6238.CBG12457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG12457; CBG12457; CBG12457.
Organism-specific databases
WormBase	CBG12457; CBP35181; WBGene00033404; Cbr-eif-3.e.
Phylogenomic databases
eggNOG	NOG324642.
HOGENOM	HOG000036697.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
HAMAP	MF_03004. eIF3e.
InterPro	IPR000717. PCI_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EIF3E_CAEBR

Accession

Primary (citable) accession number: A8XFH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project