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Protein

Eukaryotic translation initiation factor 3 subunit E

Gene

eif-3.E

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit EUniRule annotation
Short name:
eIF3eUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 6UniRule annotation
Gene namesi
Name:eif-3.EUniRule annotationImported
ORF Names:CBG12457Imported
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome I, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG12457 ; CBP45563 ; WBGene00033404 ; Cbr-eif-3.E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003659771 – 311Eukaryotic translation initiation factor 3 subunit EAdd BLAST311

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi6238.CBG12457

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 280PCIPROSITE-ProRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the eIF-3 subunit E family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2758 Eukaryota
ENOG410XQK5 LUCA
HOGENOMiHOG000036697
InParanoidiA8XFH3
OMAiHINVHEQ
OrthoDBiEOG091G075K

Family and domain databases

HAMAPiMF_03004 eIF3e, 1 hit
InterProiView protein in InterPro
IPR016650 eIF3e
IPR000717 PCI_dom
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10317 PTHR10317, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

A8XFH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTVDMVDTL FKYSKFMYEC GNYTVASVCL YYYRNLVNQA DPNYLNALYG
60 70 80 90 100
KLASEILLQE WEHARDDLLK LRAYIDANPF DTEWELVTQR AWLMHWALFV
110 120 130 140 150
YYNYPKGRDE IIEMFLNQQP YLNAIQVLAP HLLRYLAVAV VTSKSRQKNS
160 170 180 190 200
LKDLVKVIDI ERHSYKDPVT DFLTCLYIKY DFDEAQEMLQ KCEEVLSNDF
210 220 230 240 250
FLTAVLGDFR ESARLLIFEM FCRIHQCITI EMLARRLNMS QEEAERWIVD
260 270 280 290 300
LIRTYRIEGA KIDSKLGQVV MGVKSVSIHE QVMENTKRLT LRAQQIALQL
310
EKGRQDKVKA N
Length:311
Mass (Da):36,685
Last modified:December 16, 2008 - v2
Checksum:i82AFD4D0196BD7C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600913 Genomic DNA Translation: CAP31434.2

Similar proteinsi

Entry informationi

Entry nameiEIF3E_CAEBR
AccessioniPrimary (citable) accession number: A8XFH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health