A8XFG2 (NDUS7_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
EC=1.6.5.3
EC=1.6.99.3

Gene names

Name:	nduf-7
ORF Names:	CBG12445

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. UniProtKB P42026
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol. UniProtKB Q94360 NADH + acceptor = NAD+ + reduced acceptor. UniProtKB Q94360
Cofactor	Binds 1 4Fe-4S cluster Potential.
Subunit structure	Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity. UniProtKB P42026
Subcellular location	Mitochondrion By similarity UniProtKB P42026.
Sequence similarities	Belongs to the complex I 20 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 16	16	Mitochondrion Potential
	Chain	17 – 199	183	Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial		PRO_0000395332
Sites
	Metal binding	74	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	75	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	139	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	169	1	Iron-sulfur (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	A8XFG2 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: D617BEE4605514C5	FASTA	199	21,975
	10 20 30 40 50 60 MLSALRTAGA LSTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL ARLDDVMNLA 70 80 90 100 110 120 QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP RQADLIFVAG TVTNKMAPAL 130 140 150 160 170 180 RRIYDQMPEA KWVISMGSCA NGGGYYHYAY SVLRGCDRVI PVDIYVPGCP PTAEALLYGV 190 LQLQKKIKRK REAQLWYRR

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE600913 Genomic DNA. Translation: CAP31423.1.
RefSeq	XP_002639719.1. XM_002639673.1.
3D structure databases
ProteinModelPortal	A8XFG2.
ModBase	Search...
Protein-protein interaction databases
STRING	6238.CBG12445.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG12445; CBG12445; CBG12445.
GeneID	8581712.
KEGG	cbr:CBG12445.
Organism-specific databases
CTD	8581712.
WormBase	CBG12445; CBP03002; WBGene00033393; Cbr-nduf-7.
Phylogenomic databases
eggNOG	COG0377.
HOGENOM	HOG000228249.
KO	K03940.
OMA	INYTRTG.
Family and domain databases
Gene3D	3.40.50.700. 1 hit.
InterPro	IPR006137. NADH_UbQ_OxRdtase-like_20kDa. IPR006138. NADH_UQ_OxRdtase_20Kd_su. IPR014406. NiFe-hyd_3_ssu/Q_oxred_NuoB. [Graphical view]
PANTHER	PTHR11995. PTHR11995. 1 hit.
Pfam	PF01058. Oxidored_q6. 1 hit. [Graphical view]
TIGRFAMs	TIGR01957. nuoB_fam. 1 hit.
PROSITE	PS01150. COMPLEX1_20K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS7_CAEBR

Accession

Primary (citable) accession number: A8XFG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	January 15, 2008
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project