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A8XFG2

- NDUS7_CAEBR

UniProt

A8XFG2 - NDUS7_CAEBR

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Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene
nduf-7, CBG12445
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.UniRule annotation

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).UniRule annotation
NADH + acceptor = NAD+ + reduced acceptor.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi75 – 751Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi139 – 1391Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi169 – 1691Iron-sulfur (4Fe-4S) Reviewed prediction

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:nduf-7
ORF Names:CBG12445
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG12445; CBP03002; WBGene00033393; Cbr-nduf-7.

Subcellular locationi

Mitochondrion By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion Reviewed predictionAdd
BLAST
Chaini17 – 199183Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialUniRule annotationPRO_0000395332Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Protein-protein interaction databases

STRINGi6238.CBG12445.

Structurei

3D structure databases

ProteinModelPortaliA8XFG2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0377.
HOGENOMiHOG000228249.
KOiK03940.
OMAiYAINWGR.
OrthoDBiEOG7C8GJ9.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XFG2-1 [UniParc]FASTAAdd to Basket

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MLSALRTAGA LSTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL    50
ARLDDVMNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP 100
RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY 150
SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR 199
Length:199
Mass (Da):21,975
Last modified:January 15, 2008 - v1
Checksum:iD617BEE4605514C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600913 Genomic DNA. Translation: CAP31423.1.
RefSeqiXP_002639719.1. XM_002639673.1.

Genome annotation databases

EnsemblMetazoaiCBG12445; CBG12445; CBG12445.
GeneIDi8581712.
KEGGicbr:CBG12445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600913 Genomic DNA. Translation: CAP31423.1 .
RefSeqi XP_002639719.1. XM_002639673.1.

3D structure databases

ProteinModelPortali A8XFG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG12445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG12445 ; CBG12445 ; CBG12445 .
GeneIDi 8581712.
KEGGi cbr:CBG12445.

Organism-specific databases

CTDi 8581712.
WormBasei CBG12445 ; CBP03002 ; WBGene00033393 ; Cbr-nduf-7.

Phylogenomic databases

eggNOGi COG0377.
HOGENOMi HOG000228249.
KOi K03940.
OMAi YAINWGR.
OrthoDBi EOG7C8GJ9.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiNDUS7_CAEBR
AccessioniPrimary (citable) accession number: A8XFG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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