Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8XFG2

- NDUS7_CAEBR

UniProt

A8XFG2 - NDUS7_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

nduf-7

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

Binds 1 4Fe-4S cluster.Sequence Analysis

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi75 – 751Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi139 – 1391Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi169 – 1691Iron-sulfur (4Fe-4S)Sequence Analysis

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialBy similarity (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Name:nduf-7Imported
ORF Names:CBG12445
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG12445; CBP03002; WBGene00033393; Cbr-nduf-7.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616MitochondrionSequence AnalysisAdd
BLAST
Chaini17 – 199183Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialSequence AnalysisPRO_0000395332Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

STRINGi6238.CBG12445.

Structurei

3D structure databases

ProteinModelPortaliA8XFG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Sequence Analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0377.
HOGENOMiHOG000228249.
InParanoidiA8XFG2.
KOiK03940.
OMAiYAINWGR.
OrthoDBiEOG7C8GJ9.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XFG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSALRTAGA LSTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL
60 70 80 90 100
ARLDDVMNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP
110 120 130 140 150
RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY
160 170 180 190
SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR
Length:199
Mass (Da):21,975
Last modified:January 15, 2008 - v1
Checksum:iD617BEE4605514C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600913 Genomic DNA. Translation: CAP31423.1.
RefSeqiXP_002639719.1. XM_002639673.1.

Genome annotation databases

EnsemblMetazoaiCBG12445; CBG12445; CBG12445.
GeneIDi8581712.
KEGGicbr:CBG12445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600913 Genomic DNA. Translation: CAP31423.1 .
RefSeqi XP_002639719.1. XM_002639673.1.

3D structure databases

ProteinModelPortali A8XFG2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG12445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG12445 ; CBG12445 ; CBG12445 .
GeneIDi 8581712.
KEGGi cbr:CBG12445.

Organism-specific databases

CTDi 8581712.
WormBasei CBG12445 ; CBP03002 ; WBGene00033393 ; Cbr-nduf-7.

Phylogenomic databases

eggNOGi COG0377.
HOGENOMi HOG000228249.
InParanoidi A8XFG2.
KOi K03940.
OMAi YAINWGR.
OrthoDBi EOG7C8GJ9.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
HAMAPi MF_01356. NDH1_NuoB.
InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view ]
Pfami PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
PROSITEi PS01150. COMPLEX1_20K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiNDUS7_CAEBR
AccessioniPrimary (citable) accession number: A8XFG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3