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A8XFG2 (NDUS7_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Gene names
Name:nduf-7
ORF Names:CBG12445
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. HAMAP-Rule MF_01356

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01356

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01356

Cofactor

Binds 1 4Fe-4S cluster Potential.

Subunit structure

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01356.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1616Mitochondrion Potential
Chain17 – 199183Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial HAMAP-Rule MF_01356
PRO_0000395332

Sites

Metal binding741Iron-sulfur (4Fe-4S) Potential
Metal binding751Iron-sulfur (4Fe-4S) Potential
Metal binding1391Iron-sulfur (4Fe-4S) Potential
Metal binding1691Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A8XFG2 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: D617BEE4605514C5

FASTA19921,975
        10         20         30         40         50         60 
MLSALRTAGA LSTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL ARLDDVMNLA 

        70         80         90        100        110        120 
QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP RQADLIFVAG TVTNKMAPAL 

       130        140        150        160        170        180 
RRIYDQMPEA KWVISMGSCA NGGGYYHYAY SVLRGCDRVI PVDIYVPGCP PTAEALLYGV 

       190 
LQLQKKIKRK REAQLWYRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600913 Genomic DNA. Translation: CAP31423.1.
RefSeqXP_002639719.1. XM_002639673.1.

3D structure databases

ProteinModelPortalA8XFG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG12445.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG12445; CBG12445; CBG12445.
GeneID8581712.
KEGGcbr:CBG12445.

Organism-specific databases

CTD8581712.
WormBaseCBG12445; CBP03002; WBGene00033393; Cbr-nduf-7.

Phylogenomic databases

eggNOGCOG0377.
HOGENOMHOG000228249.
KOK03940.
OMAYAINWGR.
OrthoDBEOG7C8GJ9.

Family and domain databases

Gene3D3.40.50.700. 1 hit.
HAMAPMF_01356. NDH1_NuoB.
InterProIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS7_CAEBR
AccessionPrimary (citable) accession number: A8XFG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families