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A8XFG2

- NDUS7_CAEBR

UniProt

A8XFG2 - NDUS7_CAEBR

Protein

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

nduf-7

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.By similarity

    Cofactori

    Binds 1 4Fe-4S cluster.Sequence Analysis

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi75 – 751Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi139 – 1391Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi169 – 1691Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    4. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialBy similarity (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    Name:nduf-7Imported
    ORF Names:CBG12445
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG12445; CBP03002; WBGene00033393; Cbr-nduf-7.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1616MitochondrionSequence AnalysisAdd
    BLAST
    Chaini17 – 199183Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialSequence AnalysisPRO_0000395332Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Protein-protein interaction databases

    STRINGi6238.CBG12445.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XFG2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 20 kDa subunit family.Sequence Analysis

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0377.
    HOGENOMiHOG000228249.
    KOiK03940.
    OMAiYAINWGR.
    OrthoDBiEOG7C8GJ9.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    HAMAPiMF_01356. NDH1_NuoB.
    InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view]
    PfamiPF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
    PROSITEiPS01150. COMPLEX1_20K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8XFG2-1 [UniParc]FASTAAdd to Basket

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    MLSALRTAGA LSTRRLASTQ AIASNSEAPK GIATTGTPFL NPSSKAEYAL    50
    ARLDDVMNLA QRGSIWPLTF GLACCAVEMM HFAAPRYDMD RYGVVFRASP 100
    RQADLIFVAG TVTNKMAPAL RRIYDQMPEA KWVISMGSCA NGGGYYHYAY 150
    SVLRGCDRVI PVDIYVPGCP PTAEALLYGV LQLQKKIKRK REAQLWYRR 199
    Length:199
    Mass (Da):21,975
    Last modified:January 15, 2008 - v1
    Checksum:iD617BEE4605514C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600913 Genomic DNA. Translation: CAP31423.1.
    RefSeqiXP_002639719.1. XM_002639673.1.

    Genome annotation databases

    EnsemblMetazoaiCBG12445; CBG12445; CBG12445.
    GeneIDi8581712.
    KEGGicbr:CBG12445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600913 Genomic DNA. Translation: CAP31423.1 .
    RefSeqi XP_002639719.1. XM_002639673.1.

    3D structure databases

    ProteinModelPortali A8XFG2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG12445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG12445 ; CBG12445 ; CBG12445 .
    GeneIDi 8581712.
    KEGGi cbr:CBG12445.

    Organism-specific databases

    CTDi 8581712.
    WormBasei CBG12445 ; CBP03002 ; WBGene00033393 ; Cbr-nduf-7.

    Phylogenomic databases

    eggNOGi COG0377.
    HOGENOMi HOG000228249.
    KOi K03940.
    OMAi YAINWGR.
    OrthoDBi EOG7C8GJ9.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    HAMAPi MF_01356. NDH1_NuoB.
    InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view ]
    Pfami PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
    PROSITEi PS01150. COMPLEX1_20K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiNDUS7_CAEBR
    AccessioniPrimary (citable) accession number: A8XFG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3