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Protein

Abnormal cell lineage protein 44

Gene

lin-44

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Abnormal cell lineage protein 441 PublicationImported
Alternative name(s):
Wnt protein1 Publication
Gene namesi
Name:lin-44Imported
ORF Names:CBG12066
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome I, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG12066; CBP33782; WBGene00033074; Cbr-lin-44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 341320Abnormal cell lineage protein 44Sequence AnalysisPRO_0000403172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi84 ↔ 95By similarity
Disulfide bondi134 ↔ 142By similarity
Disulfide bondi144 ↔ 158By similarity
Disulfide bondi206 ↔ 220By similarity
Disulfide bondi208 ↔ 215By similarity
Lipidationi212 – 2121O-palmitoleyl serine; by mom-1By similarity
Disulfide bondi275 ↔ 292By similarity
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi307 ↔ 331By similarity
Disulfide bondi307 ↔ 322By similarity
Disulfide bondi309 ↔ 319By similarity
Disulfide bondi314 ↔ 315By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi287 – 32236Cys-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the Wnt family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiA8XEH1.
OMAiIQLACRS.
OrthoDBiEOG7SXW7G.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8XEH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALYFRTTT LSTFFILCSL ASNDIPRTGG NKIVQPPKPN ILKQGCPSDL
60 70 80 90 100
LHSRALRSIQ LACRSHPATV ISAFEGIQEG LQNCANRLRF QQWDCSEAGN
110 120 130 140 150
IMHDPPLLRQ GFRESSLIWA LSSASAAWGV ATACAQGWID DCACNNHMGQ
160 170 180 190 200
NEYEFGGCTH GVQHGITASR KLLTKVGAVN SLLRKVEKHN LKAGRLAIKK
210 220 230 240 250
TLISSCKCHG VSGSCQQKTC WKRTATLEHI TDYLVEKYAR AKLYTDDSVV
260 270 280 290 300
KTTDLIYLEA SPDVCKVKSV AGRVCAWRNE THTQGDCDRL CCGNGFSIRH
310 320 330 340
EVVRVKCDCE FVWCCNLVCK DCIQHRWIST CNGTPPKSLI F
Length:341
Mass (Da):37,831
Last modified:December 16, 2008 - v2
Checksum:i5E24CD3DB58052C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601540 Genomic DNA. Translation: CAP31106.2.

Genome annotation databases

EnsemblMetazoaiCBG12066; CBG12066; CBG12066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601540 Genomic DNA. Translation: CAP31106.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG12066; CBG12066; CBG12066.

Organism-specific databases

WormBaseiCBG12066; CBP33782; WBGene00033074; Cbr-lin-44.

Phylogenomic databases

InParanoidiA8XEH1.
OMAiIQLACRS.
OrthoDBiEOG7SXW7G.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.
  2. "Comparative analysis of embryonic cell lineage between Caenorhabditis briggsae and Caenorhabditis elegans."
    Zhao Z., Boyle T.J., Bao Z., Murray J.I., Mericle B., Waterston R.H.
    Dev. Biol. 314:93-99(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLIN44_CAEBR
AccessioniPrimary (citable) accession number: A8XEH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: December 16, 2008
Last modified: April 29, 2015
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.