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A8XEH1

- LIN44_CAEBR

UniProt

A8XEH1 - LIN44_CAEBR

Protein

Abnormal cell lineage protein 44

Gene

lin-44

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abnormal cell lineage protein 44Imported1 Publication
    Alternative name(s):
    Wnt protein1 Publication
    Gene namesi
    Name:lin-44Imported
    ORF Names:CBG12066
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome I, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG12066; CBP33782; WBGene00033074; Cbr-lin-44.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 341320Abnormal cell lineage protein 44Sequence AnalysisPRO_0000403172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi84 ↔ 95By similarity
    Disulfide bondi134 ↔ 142By similarity
    Disulfide bondi144 ↔ 158By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Disulfide bondi275 ↔ 292By similarity
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi307 ↔ 322By similarity
    Disulfide bondi309 ↔ 319By similarity
    Disulfide bondi314 ↔ 315By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi287 – 32236Cys-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Wnt family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7SXW7G.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8XEH1-1 [UniParc]FASTAAdd to Basket

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    MRALYFRTTT LSTFFILCSL ASNDIPRTGG NKIVQPPKPN ILKQGCPSDL    50
    LHSRALRSIQ LACRSHPATV ISAFEGIQEG LQNCANRLRF QQWDCSEAGN 100
    IMHDPPLLRQ GFRESSLIWA LSSASAAWGV ATACAQGWID DCACNNHMGQ 150
    NEYEFGGCTH GVQHGITASR KLLTKVGAVN SLLRKVEKHN LKAGRLAIKK 200
    TLISSCKCHG VSGSCQQKTC WKRTATLEHI TDYLVEKYAR AKLYTDDSVV 250
    KTTDLIYLEA SPDVCKVKSV AGRVCAWRNE THTQGDCDRL CCGNGFSIRH 300
    EVVRVKCDCE FVWCCNLVCK DCIQHRWIST CNGTPPKSLI F 341
    Length:341
    Mass (Da):37,831
    Last modified:December 16, 2008 - v2
    Checksum:i5E24CD3DB58052C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601540 Genomic DNA. Translation: CAP31106.2.

    Genome annotation databases

    EnsemblMetazoaiCBG12066; CBG12066; CBG12066.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601540 Genomic DNA. Translation: CAP31106.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG12066 ; CBG12066 ; CBG12066 .

    Organism-specific databases

    WormBasei CBG12066 ; CBP33782 ; WBGene00033074 ; Cbr-lin-44.

    Phylogenomic databases

    OrthoDBi EOG7SXW7G.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.
    2. "Comparative analysis of embryonic cell lineage between Caenorhabditis briggsae and Caenorhabditis elegans."
      Zhao Z., Boyle T.J., Bao Z., Murray J.I., Mericle B., Waterston R.H.
      Dev. Biol. 314:93-99(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiLIN44_CAEBR
    AccessioniPrimary (citable) accession number: A8XEH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3