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A8XEH1 (LIN44_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abnormal cell lineage protein 44
Alternative name(s):
Wnt protein
Gene names
Name:lin-44
ORF Names:CBG12066
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors By similarity. Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis By similarity. UniProtKB Q27886

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity UniProtKB P24383.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 341320Abnormal cell lineage protein 44
PRO_0000403172

Regions

Compositional bias287 – 32236Cys-rich

Amino acid modifications

Glycosylation2791N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A8XEH1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 5E24CD3DB58052C3

FASTA34137,831
        10         20         30         40         50         60 
MRALYFRTTT LSTFFILCSL ASNDIPRTGG NKIVQPPKPN ILKQGCPSDL LHSRALRSIQ 

        70         80         90        100        110        120 
LACRSHPATV ISAFEGIQEG LQNCANRLRF QQWDCSEAGN IMHDPPLLRQ GFRESSLIWA 

       130        140        150        160        170        180 
LSSASAAWGV ATACAQGWID DCACNNHMGQ NEYEFGGCTH GVQHGITASR KLLTKVGAVN 

       190        200        210        220        230        240 
SLLRKVEKHN LKAGRLAIKK TLISSCKCHG VSGSCQQKTC WKRTATLEHI TDYLVEKYAR 

       250        260        270        280        290        300 
AKLYTDDSVV KTTDLIYLEA SPDVCKVKSV AGRVCAWRNE THTQGDCDRL CCGNGFSIRH 

       310        320        330        340 
EVVRVKCDCE FVWCCNLVCK DCIQHRWIST CNGTPPKSLI F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601540 Genomic DNA. Translation: CAP31106.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG12066; CBG12066; CBG12066.

Organism-specific databases

WormBaseCBG12066; CBP33782; WBGene00033074; Cbr-lin-44.

Phylogenomic databases

OrthoDBEOG7SXW7G.

Family and domain databases

InterProIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIN44_CAEBR
AccessionPrimary (citable) accession number: A8XEH1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families