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A8XE00

- PP4C1_CAEBR

UniProt

A8XE00 - PP4C1_CAEBR

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 1

Gene
pph-4.1, CBG11776
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi81 – 811Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 2 By similarity
Metal bindingi139 – 1391Manganese 2 By similarity
Active sitei140 – 1401Proton donor By similarity
Metal bindingi189 – 1891Manganese 2 By similarity
Metal bindingi264 – 2641Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
Short name:
PP4C-1
Gene namesi
Name:pph-4.1
ORF Names:CBG11776
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG11776; CBP02888; WBGene00032850; Cbr-pph-4.1.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1PRO_0000353209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Leucine methyl ester By similarity

Post-translational modificationi

Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliA8XE00.
SMRiA8XE00. Positions 25-333.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG74N5H2.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XE00-1 [UniParc]FASTAAdd to Basket

« Hide

MALAVADTQN ETFARSESPT SGPSDQLSTH DLDRHIEKLM RCELIAEQDV    50
KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FRVGGPVPNT 100
NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG 150
FYDECMRKYG NASVWKHCTE VFDYLALAAV IDGKVFCVHG GLSPSISTMD 200
QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT 250
FCEANSVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 300
LDENLNREFT IFEAAPQENR GAPAKKPHAD YFL 333
Length:333
Mass (Da):37,469
Last modified:January 15, 2008 - v1
Checksum:i90F18DEC1D925BDC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601289 Genomic DNA. Translation: CAP30806.3.
RefSeqiXP_002641024.1. XM_002640978.1.

Genome annotation databases

EnsemblMetazoaiCBG11776; CBG11776; CBG11776.
GeneIDi8583018.
KEGGicbr:CBG11776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601289 Genomic DNA. Translation: CAP30806.3 .
RefSeqi XP_002641024.1. XM_002640978.1.

3D structure databases

ProteinModelPortali A8XE00.
SMRi A8XE00. Positions 25-333.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG11776 ; CBG11776 ; CBG11776 .
GeneIDi 8583018.
KEGGi cbr:CBG11776.

Organism-specific databases

CTDi 8583018.
WormBasei CBG11776 ; CBP02888 ; WBGene00032850 ; Cbr-pph-4.1.

Phylogenomic databases

HOGENOMi HOG000172696.
KOi K15423.
OMAi VFNHRND.
OrthoDBi EOG74N5H2.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiPP4C1_CAEBR
AccessioniPrimary (citable) accession number: A8XE00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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