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A8XE00

- PP4C1_CAEBR

UniProt

A8XE00 - PP4C1_CAEBR

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 1

Gene

pph-4.1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Manganese 1By similarity
Metal bindingi81 – 811Manganese 1By similarity
Metal bindingi107 – 1071Manganese 1By similarity
Metal bindingi107 – 1071Manganese 2By similarity
Metal bindingi139 – 1391Manganese 2By similarity
Active sitei140 – 1401Proton donorBy similarity
Metal bindingi189 – 1891Manganese 2By similarity
Metal bindingi264 – 2641Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
Short name:
PP4C-1
Gene namesi
Name:pph-4.1
ORF Names:CBG11776
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG11776; CBP02888; WBGene00032850; Cbr-pph-4.1.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1PRO_0000353209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Leucine methyl esterBy similarity

Post-translational modificationi

Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).By similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Structurei

3D structure databases

ProteinModelPortaliA8XE00.
SMRiA8XE00. Positions 25-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiA8XE00.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG74N5H2.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XE00-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALAVADTQN ETFARSESPT SGPSDQLSTH DLDRHIEKLM RCELIAEQDV
60 70 80 90 100
KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FRVGGPVPNT
110 120 130 140 150
NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG
160 170 180 190 200
FYDECMRKYG NASVWKHCTE VFDYLALAAV IDGKVFCVHG GLSPSISTMD
210 220 230 240 250
QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT
260 270 280 290 300
FCEANSVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE
310 320 330
LDENLNREFT IFEAAPQENR GAPAKKPHAD YFL
Length:333
Mass (Da):37,469
Last modified:January 15, 2008 - v1
Checksum:i90F18DEC1D925BDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601289 Genomic DNA. Translation: CAP30806.3.
RefSeqiXP_002641024.1. XM_002640978.1.

Genome annotation databases

EnsemblMetazoaiCBG11776; CBG11776; CBG11776.
GeneIDi8583018.
KEGGicbr:CBG11776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601289 Genomic DNA. Translation: CAP30806.3 .
RefSeqi XP_002641024.1. XM_002640978.1.

3D structure databases

ProteinModelPortali A8XE00.
SMRi A8XE00. Positions 25-333.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG11776 ; CBG11776 ; CBG11776 .
GeneIDi 8583018.
KEGGi cbr:CBG11776.

Organism-specific databases

CTDi 8583018.
WormBasei CBG11776 ; CBP02888 ; WBGene00032850 ; Cbr-pph-4.1.

Phylogenomic databases

HOGENOMi HOG000172696.
InParanoidi A8XE00.
KOi K15423.
OMAi VFNHRND.
OrthoDBi EOG74N5H2.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiPP4C1_CAEBR
AccessioniPrimary (citable) accession number: A8XE00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3