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A8XE00

- PP4C1_CAEBR

UniProt

A8XE00 - PP4C1_CAEBR

Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 1

Gene

pph-4.1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 2By similarity
    Metal bindingi139 – 1391Manganese 2By similarity
    Active sitei140 – 1401Proton donorBy similarity
    Metal bindingi189 – 1891Manganese 2By similarity
    Metal bindingi264 – 2641Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
    Short name:
    PP4C-1
    Gene namesi
    Name:pph-4.1
    ORF Names:CBG11776
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG11776; CBP02888; WBGene00032850; Cbr-pph-4.1.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1PRO_0000353209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Leucine methyl esterBy similarity

    Post-translational modificationi

    Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.By similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA8XE00.
    SMRiA8XE00. Positions 25-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000172696.
    KOiK15423.
    OMAiVFNHRND.
    OrthoDBiEOG74N5H2.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XE00-1 [UniParc]FASTAAdd to Basket

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    MALAVADTQN ETFARSESPT SGPSDQLSTH DLDRHIEKLM RCELIAEQDV    50
    KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FRVGGPVPNT 100
    NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG 150
    FYDECMRKYG NASVWKHCTE VFDYLALAAV IDGKVFCVHG GLSPSISTMD 200
    QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT 250
    FCEANSVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 300
    LDENLNREFT IFEAAPQENR GAPAKKPHAD YFL 333
    Length:333
    Mass (Da):37,469
    Last modified:January 15, 2008 - v1
    Checksum:i90F18DEC1D925BDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601289 Genomic DNA. Translation: CAP30806.3.
    RefSeqiXP_002641024.1. XM_002640978.1.

    Genome annotation databases

    EnsemblMetazoaiCBG11776; CBG11776; CBG11776.
    GeneIDi8583018.
    KEGGicbr:CBG11776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601289 Genomic DNA. Translation: CAP30806.3 .
    RefSeqi XP_002641024.1. XM_002640978.1.

    3D structure databases

    ProteinModelPortali A8XE00.
    SMRi A8XE00. Positions 25-333.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG11776 ; CBG11776 ; CBG11776 .
    GeneIDi 8583018.
    KEGGi cbr:CBG11776.

    Organism-specific databases

    CTDi 8583018.
    WormBasei CBG11776 ; CBP02888 ; WBGene00032850 ; Cbr-pph-4.1.

    Phylogenomic databases

    HOGENOMi HOG000172696.
    KOi K15423.
    OMAi VFNHRND.
    OrthoDBi EOG74N5H2.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiPP4C1_CAEBR
    AccessioniPrimary (citable) accession number: A8XE00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3