SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8XE00

- PP4C1_CAEBR

UniProt

A8XE00 - PP4C1_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein phosphatase 4 catalytic subunit 1
Gene
pph-4.1, CBG11776
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi81 – 811Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 2 By similarity
Metal bindingi139 – 1391Manganese 2 By similarity
Active sitei140 – 1401Proton donor By similarity
Metal bindingi189 – 1891Manganese 2 By similarity
Metal bindingi264 – 2641Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
    Short name:
    PP4C-1
    Gene namesi
    Name:pph-4.1
    ORF Names:CBG11776
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome III, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG11776; CBP02888; WBGene00032850; Cbr-pph-4.1.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle By similarity.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule organizing center Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1
    PRO_0000353209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Leucine methyl ester By similarity

    Post-translational modificationi

    Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.

    Keywords - PTMi

    Methylation

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XE00.
    SMRiA8XE00. Positions 25-333.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000172696.
    KOiK15423.
    OMAiVFNHRND.
    OrthoDBiEOG74N5H2.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XE00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALAVADTQN ETFARSESPT SGPSDQLSTH DLDRHIEKLM RCELIAEQDV    50
    KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FRVGGPVPNT 100
    NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG 150
    FYDECMRKYG NASVWKHCTE VFDYLALAAV IDGKVFCVHG GLSPSISTMD 200
    QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT 250
    FCEANSVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 300
    LDENLNREFT IFEAAPQENR GAPAKKPHAD YFL 333
    Length:333
    Mass (Da):37,469
    Last modified:January 15, 2008 - v1
    Checksum:i90F18DEC1D925BDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601289 Genomic DNA. Translation: CAP30806.3.
    RefSeqiXP_002641024.1. XM_002640978.1.

    Genome annotation databases

    EnsemblMetazoaiCBG11776; CBG11776; CBG11776.
    GeneIDi8583018.
    KEGGicbr:CBG11776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601289 Genomic DNA. Translation: CAP30806.3 .
    RefSeqi XP_002641024.1. XM_002640978.1.

    3D structure databases

    ProteinModelPortali A8XE00.
    SMRi A8XE00. Positions 25-333.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG11776 ; CBG11776 ; CBG11776 .
    GeneIDi 8583018.
    KEGGi cbr:CBG11776.

    Organism-specific databases

    CTDi 8583018.
    WormBasei CBG11776 ; CBP02888 ; WBGene00032850 ; Cbr-pph-4.1.

    Phylogenomic databases

    HOGENOMi HOG000172696.
    KOi K15423.
    OMAi VFNHRND.
    OrthoDBi EOG74N5H2.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiPP4C1_CAEBR
    AccessioniPrimary (citable) accession number: A8XE00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: January 15, 2008
    Last modified: July 9, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi