Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8XE00 (PP4C1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 1

Short name=PP4C-1
EC=3.1.3.16
Gene names
Name:pph-4.1
ORF Names:CBG11776
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subunit structure

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle By similarity.

Post-translational modification

Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1
PRO_0000353209

Sites

Active site1401Proton donor By similarity
Metal binding791Manganese 1 By similarity
Metal binding811Manganese 1 By similarity
Metal binding1071Manganese 1 By similarity
Metal binding1071Manganese 2 By similarity
Metal binding1391Manganese 2 By similarity
Metal binding1891Manganese 2 By similarity
Metal binding2641Manganese 2 By similarity

Amino acid modifications

Modified residue3331Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
A8XE00 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 90F18DEC1D925BDC

FASTA33337,469
        10         20         30         40         50         60 
MALAVADTQN ETFARSESPT SGPSDQLSTH DLDRHIEKLM RCELIAEQDV KTLCAKAREI 

        70         80         90        100        110        120 
LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FRVGGPVPNT NYLFLGDFVD RGFYSVETFL 

       130        140        150        160        170        180 
LLLALKARYP DRMMLIRGNH ESRQITQVYG FYDECMRKYG NASVWKHCTE VFDYLALAAV 

       190        200        210        220        230        240 
IDGKVFCVHG GLSPSISTMD QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG 

       250        260        270        280        290        300 
YLFGADASKT FCEANSVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 

       310        320        330 
LDENLNREFT IFEAAPQENR GAPAKKPHAD YFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601289 Genomic DNA. Translation: CAP30806.3.
RefSeqXP_002641024.1. XM_002640978.1.

3D structure databases

ProteinModelPortalA8XE00.
SMRA8XE00. Positions 25-333.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG11776; CBG11776; CBG11776.
GeneID8583018.
KEGGcbr:CBG11776.

Organism-specific databases

CTD8583018.
WormBaseCBG11776; CBP02888; WBGene00032850; Cbr-pph-4.1.

Phylogenomic databases

HOGENOMHOG000172696.
KOK15423.
OMAVFNHRND.
OrthoDBEOG74N5H2.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP4C1_CAEBR
AccessionPrimary (citable) accession number: A8XE00
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families