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A8XDJ2

- OTUBL_CAEBR

UniProt

A8XDJ2 - OTUBL_CAEBR

Protein

Ubiquitin thioesterase otubain-like

Gene

otub-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841By similarity
    Active sitei87 – 871NucleophileBy similarity
    Active sitei268 – 2681By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. omega peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC65.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin thioesterase otubain-likeBy similarity (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme otubain-likeBy similarity
    Ubiquitin-specific-processing protease otubain-likeBy similarity
    Gene namesi
    Name:otub-1Imported
    ORF Names:CBG11576
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG11576; CBP17228; WBGene00032679; Cbr-otub-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Ubiquitin thioesterase otubain-likePRO_0000394766Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG11576.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XDJ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 275200OTUPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C65 family.Sequence Analysis
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000019496.
    KOiK09602.
    OMAiVEPMYKE.
    OrthoDBiEOG71K64D.

    Family and domain databases

    InterProiIPR003323. OTU.
    IPR019400. Peptidase_C65_otubain.
    IPR016615. Ubiquitin_thioesterase_Otubain.
    [Graphical view]
    PfamiPF10275. Peptidase_C65. 1 hit.
    [Graphical view]
    PIRSFiPIRSF013503. Ubiquitin_thioesterase_Otubain. 1 hit.
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XDJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNDTSENQP TTAGIVTTTE DELILQDQQM KRIEDEQKAS PLVGEKMPCA    50
    TLVSLYDQET APAFFEKANE LAKVYSHIRF IRGDGNCFIR AIQVGLVEIL 100
    LNDKERLVKF IASCKEWTER LVKLGFPDWT CTDFCEFFIE FIEKVRDGIH 150
    QKEDVFRIFN DDNTANYLLM FFRLITSGYL KEHAAEYEPF LDEGMSLAQY 200
    CETEIEAMWK ESDHLGIIAL VRALNIRIRI EYMDRNAAPN GGTHHNLPDG 250
    HDNATFTPDI TLLYRPGHYD LIYKAPAETS KPALPPVA 288
    Length:288
    Mass (Da):32,949
    Last modified:January 15, 2008 - v1
    Checksum:iC82E79D93EE5DA87
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600985 Genomic DNA. Translation: CAP30711.1.
    RefSeqiXP_002637711.1. XM_002637665.1.

    Genome annotation databases

    EnsemblMetazoaiCBG11576; CBG11576; CBG11576.
    GeneIDi8579707.
    KEGGicbr:CBG11576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600985 Genomic DNA. Translation: CAP30711.1 .
    RefSeqi XP_002637711.1. XM_002637665.1.

    3D structure databases

    ProteinModelPortali A8XDJ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG11576.

    Protein family/group databases

    MEROPSi C65.A01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG11576 ; CBG11576 ; CBG11576 .
    GeneIDi 8579707.
    KEGGi cbr:CBG11576.

    Organism-specific databases

    CTDi 8579707.
    WormBasei CBG11576 ; CBP17228 ; WBGene00032679 ; Cbr-otub-1.

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000019496.
    KOi K09602.
    OMAi VEPMYKE.
    OrthoDBi EOG71K64D.

    Family and domain databases

    InterProi IPR003323. OTU.
    IPR019400. Peptidase_C65_otubain.
    IPR016615. Ubiquitin_thioesterase_Otubain.
    [Graphical view ]
    Pfami PF10275. Peptidase_C65. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF013503. Ubiquitin_thioesterase_Otubain. 1 hit.
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiOTUBL_CAEBR
    AccessioniPrimary (citable) accession number: A8XDJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3