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A8XDJ2 (OTUBL_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin thioesterase otubain-like

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme otubain-like
Ubiquitin-specific-processing protease otubain-like
Gene names
Name:otub-1
ORF Names:CBG11576
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin By similarity. UniProtKB Q9XVR6

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C65 family.

Contains 1 OTU domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Ubiquitin thioesterase otubain-like
PRO_0000394766

Regions

Domain76 – 275200OTU

Sites

Active site841 By similarity UniProtKB Q96FW1
Active site871Nucleophile By similarity UniProtKB Q96FW1
Active site2681 By similarity UniProtKB Q96FW1

Sequences

Sequence LengthMass (Da)Tools
A8XDJ2 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: C82E79D93EE5DA87

FASTA28832,949
        10         20         30         40         50         60 
MVNDTSENQP TTAGIVTTTE DELILQDQQM KRIEDEQKAS PLVGEKMPCA TLVSLYDQET 

        70         80         90        100        110        120 
APAFFEKANE LAKVYSHIRF IRGDGNCFIR AIQVGLVEIL LNDKERLVKF IASCKEWTER 

       130        140        150        160        170        180 
LVKLGFPDWT CTDFCEFFIE FIEKVRDGIH QKEDVFRIFN DDNTANYLLM FFRLITSGYL 

       190        200        210        220        230        240 
KEHAAEYEPF LDEGMSLAQY CETEIEAMWK ESDHLGIIAL VRALNIRIRI EYMDRNAAPN 

       250        260        270        280 
GGTHHNLPDG HDNATFTPDI TLLYRPGHYD LIYKAPAETS KPALPPVA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600985 Genomic DNA. Translation: CAP30711.1.
RefSeqXP_002637711.1. XM_002637665.1.

3D structure databases

ProteinModelPortalA8XDJ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG11576.

Protein family/group databases

MEROPSC65.A01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG11576; CBG11576; CBG11576.
GeneID8579707.
KEGGcbr:CBG11576.

Organism-specific databases

CTD8579707.
WormBaseCBG11576; CBP17228; WBGene00032679; Cbr-otub-1.

Phylogenomic databases

eggNOGCOG5539.
HOGENOMHOG000019496.
KOK09602.
OMAVEPMYKE.
OrthoDBEOG71K64D.

Family and domain databases

InterProIPR003323. OTU.
IPR019400. Peptidase_C65_otubain.
IPR016615. Ubiquitin_thioesterase_Otubain.
[Graphical view]
PfamPF10275. Peptidase_C65. 1 hit.
[Graphical view]
PIRSFPIRSF013503. Ubiquitin_thioesterase_Otubain. 1 hit.
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTUBL_CAEBR
AccessionPrimary (citable) accession number: A8XDJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries