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A8XAU4

- A8XAU4_CAEBR

UniProt

A8XAU4 - A8XAU4_CAEBR

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
dot-1.3, CBG10214, CBG_10214
Organism
Caenorhabditis briggsae
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
Name:dot-1.3Imported
ORF Names:CBG10214Imported, CBG_10214Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X

Organism-specific databases

WormBaseiCBG10214; CBP08493; WBGene00031651; Cbr-dot-1.3.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG10214.

Structurei

3D structure databases

ProteinModelPortaliA8XAU4.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000019193.
KOiK11427.
OMAiPFREAAT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XAU4-1 [UniParc]FASTAAdd to Basket

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MSKVQQNFSV VSDDADKPGP LQPASVRSLR STTKRNASSE VAGPAPKIAV    50
KVEKWTIESV CKNGRRLDLS SNEPNAASVI KTLFKEIHGS VLSKLNIHPL 100
HWDECADSEL GPFLKTFNNS VKAFRKKNPR DVLLSKENWR QKEASEFRVI 150
CDLACQLAIP NPRVLNTHYA GFSSGTYGET NIETLQKILD LLGVKEDDVF 200
MDLGSGIGQL VTFAAAYTNI AHVRGIELQQ VPAGFADENV RQFKKLMRHF 250
GEKPRPFELK LGDFNTEEIE TFLKEKATII FCNNLAFDPD LMIKLRAILQ 300
FCNNGTKIVV TQKLETTKKG RTPRDCFFTA SADTILLFET DGSEKGNVSW 350
TNNIVPYYLT TVDNYKPFRE AATRAKQEEA NRLAKLMCSK KNGAKHGEKE 400
Length:400
Mass (Da):44,793
Last modified:January 15, 2008 - v1
Checksum:i4788AB38C62D9B31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600905 Genomic DNA. Translation: CAP29759.1.
RefSeqiXP_002631953.1. XM_002631907.1.

Genome annotation databases

EnsemblMetazoaiCBG10214; CBG10214; CBG10214.
GeneIDi8573952.
KEGGicbr:CBG10214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600905 Genomic DNA. Translation: CAP29759.1 .
RefSeqi XP_002631953.1. XM_002631907.1.

3D structure databases

ProteinModelPortali A8XAU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG10214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG10214 ; CBG10214 ; CBG10214 .
GeneIDi 8573952.
KEGGi cbr:CBG10214.

Organism-specific databases

CTDi 8573952.
WormBasei CBG10214 ; CBP08493 ; WBGene00031651 ; Cbr-dot-1.3.

Phylogenomic databases

eggNOGi NOG294902.
HOGENOMi HOG000019193.
KOi K11427.
OMAi PFREAAT.
OrthoDBi EOG7W6WJV.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiA8XAU4_CAEBR
AccessioniPrimary (citable) accession number: A8XAU4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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