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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

dot-1.3

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:dot-1.3Imported
ORF Names:CBG10214Imported, CBG_10214Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componenti: Chromosome X

Organism-specific databases

WormBaseiCBG10214; CBP08493; WBGene00031651; Cbr-dot-1.3.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG10214.

Structurei

3D structure databases

ProteinModelPortaliA8XAU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000019193.
InParanoidiA8XAU4.
KOiK11427.
OMAiPFREAAT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8XAU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVQQNFSV VSDDADKPGP LQPASVRSLR STTKRNASSE VAGPAPKIAV
60 70 80 90 100
KVEKWTIESV CKNGRRLDLS SNEPNAASVI KTLFKEIHGS VLSKLNIHPL
110 120 130 140 150
HWDECADSEL GPFLKTFNNS VKAFRKKNPR DVLLSKENWR QKEASEFRVI
160 170 180 190 200
CDLACQLAIP NPRVLNTHYA GFSSGTYGET NIETLQKILD LLGVKEDDVF
210 220 230 240 250
MDLGSGIGQL VTFAAAYTNI AHVRGIELQQ VPAGFADENV RQFKKLMRHF
260 270 280 290 300
GEKPRPFELK LGDFNTEEIE TFLKEKATII FCNNLAFDPD LMIKLRAILQ
310 320 330 340 350
FCNNGTKIVV TQKLETTKKG RTPRDCFFTA SADTILLFET DGSEKGNVSW
360 370 380 390 400
TNNIVPYYLT TVDNYKPFRE AATRAKQEEA NRLAKLMCSK KNGAKHGEKE
Length:400
Mass (Da):44,793
Last modified:January 15, 2008 - v1
Checksum:i4788AB38C62D9B31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600905 Genomic DNA. Translation: CAP29759.1.
RefSeqiXP_002631953.1. XM_002631907.1.

Genome annotation databases

EnsemblMetazoaiCBG10214; CBG10214; CBG10214.
GeneIDi8573952.
KEGGicbr:CBG10214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600905 Genomic DNA. Translation: CAP29759.1.
RefSeqiXP_002631953.1. XM_002631907.1.

3D structure databases

ProteinModelPortaliA8XAU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG10214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG10214; CBG10214; CBG10214.
GeneIDi8573952.
KEGGicbr:CBG10214.

Organism-specific databases

CTDi8573952.
WormBaseiCBG10214; CBP08493; WBGene00031651; Cbr-dot-1.3.

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000019193.
InParanoidiA8XAU4.
KOiK11427.
OMAiPFREAAT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR030445. H3-K79_meTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR21451. PTHR21451. 1 hit.
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16Imported.

Entry informationi

Entry nameiA8XAU4_CAEBR
AccessioniPrimary (citable) accession number: A8XAU4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 27, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.