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A8XAU4

- A8XAU4_CAEBR

UniProt

A8XAU4 - A8XAU4_CAEBR

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

dot-1.3

Organism
Caenorhabditis briggsae
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    Name:dot-1.3Imported
    ORF Names:CBG10214Imported, CBG_10214Imported
    OrganismiCaenorhabditis briggsaeImported
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X

    Organism-specific databases

    WormBaseiCBG10214; CBP08493; WBGene00031651; Cbr-dot-1.3.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG10214.

    Structurei

    3D structure databases

    ProteinModelPortaliA8XAU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    HOGENOMiHOG000019193.
    KOiK11427.
    OMAiPFREAAT.
    OrthoDBiEOG7W6WJV.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8XAU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVQQNFSV VSDDADKPGP LQPASVRSLR STTKRNASSE VAGPAPKIAV    50
    KVEKWTIESV CKNGRRLDLS SNEPNAASVI KTLFKEIHGS VLSKLNIHPL 100
    HWDECADSEL GPFLKTFNNS VKAFRKKNPR DVLLSKENWR QKEASEFRVI 150
    CDLACQLAIP NPRVLNTHYA GFSSGTYGET NIETLQKILD LLGVKEDDVF 200
    MDLGSGIGQL VTFAAAYTNI AHVRGIELQQ VPAGFADENV RQFKKLMRHF 250
    GEKPRPFELK LGDFNTEEIE TFLKEKATII FCNNLAFDPD LMIKLRAILQ 300
    FCNNGTKIVV TQKLETTKKG RTPRDCFFTA SADTILLFET DGSEKGNVSW 350
    TNNIVPYYLT TVDNYKPFRE AATRAKQEEA NRLAKLMCSK KNGAKHGEKE 400
    Length:400
    Mass (Da):44,793
    Last modified:January 15, 2008 - v1
    Checksum:i4788AB38C62D9B31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600905 Genomic DNA. Translation: CAP29759.1.
    RefSeqiXP_002631953.1. XM_002631907.1.

    Genome annotation databases

    EnsemblMetazoaiCBG10214; CBG10214; CBG10214.
    GeneIDi8573952.
    KEGGicbr:CBG10214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600905 Genomic DNA. Translation: CAP29759.1 .
    RefSeqi XP_002631953.1. XM_002631907.1.

    3D structure databases

    ProteinModelPortali A8XAU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG10214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG10214 ; CBG10214 ; CBG10214 .
    GeneIDi 8573952.
    KEGGi cbr:CBG10214.

    Organism-specific databases

    CTDi 8573952.
    WormBasei CBG10214 ; CBP08493 ; WBGene00031651 ; Cbr-dot-1.3.

    Phylogenomic databases

    eggNOGi NOG294902.
    HOGENOMi HOG000019193.
    KOi K11427.
    OMAi PFREAAT.
    OrthoDBi EOG7W6WJV.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16Imported.

    Entry informationi

    Entry nameiA8XAU4_CAEBR
    AccessioniPrimary (citable) accession number: A8XAU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3