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A8XAU4 (A8XAU4_CAEBR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:dot-1.3 WormBase CBG10214
ORF Names:CBG10214 EMBL CAP29759.1 WormBase CBG10214, CBG_10214 EMBL CAP29759.1
OrganismCaenorhabditis briggsae [Reference proteome] EMBL CAP29759.1
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Sequences

Sequence LengthMass (Da)Tools
A8XAU4 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 4788AB38C62D9B31

FASTA40044,793
        10         20         30         40         50         60 
MSKVQQNFSV VSDDADKPGP LQPASVRSLR STTKRNASSE VAGPAPKIAV KVEKWTIESV 

        70         80         90        100        110        120 
CKNGRRLDLS SNEPNAASVI KTLFKEIHGS VLSKLNIHPL HWDECADSEL GPFLKTFNNS 

       130        140        150        160        170        180 
VKAFRKKNPR DVLLSKENWR QKEASEFRVI CDLACQLAIP NPRVLNTHYA GFSSGTYGET 

       190        200        210        220        230        240 
NIETLQKILD LLGVKEDDVF MDLGSGIGQL VTFAAAYTNI AHVRGIELQQ VPAGFADENV 

       250        260        270        280        290        300 
RQFKKLMRHF GEKPRPFELK LGDFNTEEIE TFLKEKATII FCNNLAFDPD LMIKLRAILQ 

       310        320        330        340        350        360 
FCNNGTKIVV TQKLETTKKG RTPRDCFFTA SADTILLFET DGSEKGNVSW TNNIVPYYLT 

       370        380        390        400 
TVDNYKPFRE AATRAKQEEA NRLAKLMCSK KNGAKHGEKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600905 Genomic DNA. Translation: CAP29759.1.
RefSeqXP_002631953.1. XM_002631907.1.

3D structure databases

ProteinModelPortalA8XAU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG10214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG10214; CBG10214; CBG10214.
GeneID8573952.
KEGGcbr:CBG10214.

Organism-specific databases

CTD8573952.
WormBaseCBG10214; CBP08493; WBGene00031651; Cbr-dot-1.3.

Phylogenomic databases

eggNOGNOG294902.
HOGENOMHOG000019193.
KOK11427.
OMAPFREAAT.
OrthoDBEOG7W6WJV.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8XAU4_CAEBR
AccessionPrimary (citable) accession number: A8XAU4
Entry history
Integrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)